Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Advances in Understanding the Mechanistic Underpinnings of Evolution |
| Discussion Leader: Christine Queitsch (University of Washington School of Medicine, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:30 pm | Susan Rosenberg (Baylor College of Medicine, USA) "How Bacteria and Cancer Cells Regulate Mutation and
Their Ability to Evolve" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Stanislas Leibler (The Rockefeller University, USA) "Physics in Biology: Is There an Elephant in the Room?" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genome Architecture and Evolvability |
| Discussion Leader: Lilach Hadany (Tel Aviv University, Israel) |
9:00 am - 9:25 am | Evan Eichler (University of Washington / Howard Hughes Medical Institute, USA) "Dynamic Duplications and Their Role in Human Disease
and Evolution" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Doris Bachtrog (University of California, Berkeley, USA) "Transposable Elements Crowd-Source Mutations to Rapidly
Fine-Tune Regulatory Networks" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Detlef Weigel (Max Planck Institute for Developmental Biology, Germany) "Origins and Consequences of (Epi)Genetic Variation in Arabidopsis thaliana and its Relatives" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Harmit Malik (Fred Hutchinson Cancer Research Center, USA) "Genetic Conflicts: Beyond the Usual Suspects" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Bernardo Lemos (Harvard School of Public Health, USA) "rDNA Copy Number and Global Gene Expression Variation" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Yaniv Erlich (Columbia University / New York Genome Center, USA) "Short Tandem Repeats Are Major Contributors to Variation in Human Gene Expression" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Insights from Laboratory Evolution |
| Discussion Leader: Benjamin Kerr (University of Washington, USA) |
7:30 pm - 7:55 pm | Andrew Murray (Harvard University, USA) "Evolving Novelty" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Jeffrey Barrick (University of Texas at Austin, USA) "Chance and Metabolic Necessity on the Road to an Evolutionary Innovation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Christopher Marx (University of Idaho, USA) "The Math of Metabolism: Mutations that Don't Like Each
Other (and Species that Do)" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Meleah Hickman (Emory University, USA) "The Dynamic Ploidy Trajectories of Tetraploid Cells Produce Aneuploid and Unconventional Euploid States and Drive Population Heterogeneity" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Physical Constraints and
Stochasticity |
| Discussion Leader: Arjun Raj (University of Pennsylvania, USA) |
9:00 am - 9:25 am | Julien Ayroles (Princeton University, USA) "Complex Genetics of Complex
Traits: The Dynamic Nature of the Genotype-Phenotype Map" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Rama Ranganathan (University of Texas, Southwestern Medical Center, USA) "The Evolutionary 'Design' of Proteins" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Sophie Martin (University of Lausanne, Switzerland) "Molecular Mechanisms of Mating Partner Choice and Fusion
in Fission Yeast" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Peter Sims (Columbia University, USA) "A Scalable Platform for Single Cell Transcriptomics" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Eric Libby (Santa Fe Institute, USA) "The Evolution of Primitive Developmental Programs from a Stochastic Response" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Shimon Bershtein (Ben-Gurion University of the Negev, Israel) "Experimental Evolution Uncovers Physical Barriers to Horizontal Gene Transfer" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Non-Traditional Mechanisms
of Inheritance |
| Discussion Leader: Douglas Fowler (University of Washington, USA) |
7:30 pm - 7:55 pm | Daniel Jarosz (Stanford University, USA) "Transient Expression of Intrinsically Disordered Proteins Fuels the Emergence of Heritable Traits" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Mary Gehring (Whitehead Institute, USA) "DNA Methylation-Based Inheritance in Plants" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Oliver Rando (University of Massachusetts Medical School, USA) "Epigenetic Inheritance in Yeast and Mice" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Kerry Geiler-Samerotte (New York University, USA) "Hsp90 Increases Buffering Capacity Against Stochastic Variation But Not New Mutations" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Predicting and Arresting Evolution |
| Discussion Leader: Susan Rosenberg (Baylor College of Medicine, USA) |
9:00 am - 9:25 am | Jesse Bloom (Fred Hutchinson Cancer Research Center, USA) "Molecular Constraints on Viral Evolution" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Maitreya Dunham (University of Washington, USA) "Modifiers of Mutation Spectrum and Evolutionary Rate
in Yeast Experimental Evolution" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Nels Elde (University of Utah, USA) "New Roles for Retrogenes in the Restriction of Retroviruses" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Kevin Esvelt (Harvard University, USA) "Sculpting Evolution with CRISPR/Cas Scalpels" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Colin Maxwell (Duke University, USA) "Single-Cell Measurements of Fecundity Reveal Genetic Variation in Age-Structured Mortality During Heat Stress in Yeast" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Angela Phillips (Massachusetts Institute of Technology, USA) "Hijacking the Host Cell's Protein Homeostasis Network to Potentiate Influenza Evolution" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Mechanisms and Consequences
of Stress-Inducible Genetic Variation |
| Discussion Leader: Ivan Matic (Inserm U1001, Université Paris Descartes, France) |
7:30 pm - 7:55 pm | Didier Mazel (Institut Pasteur, Paris, France) "Integrons,
Antibiotics, SOS Response and Horizontal Gene Transfers: Intimate Connections" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Houra Merrikh (University of Washington, USA) "Connecting Gene Orientation-Specific DNA Transactions
to Evolution" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Denise Montell (University of California, Santa Barbara, USA) "Anastasis, a Novel Cell Survival Mechanism, a Form of Stress-Induced Mutagenesis?" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Charlie Mo (University of Pennsylvania, USA) "Tuning LexA Self-Cleavage Modulates the SOS Response and Bacterial Evolution in the Presence of Antibiotics" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms of Coding and
Regulatory Evolution |
| Discussion Leader: Christophe Herman (Baylor College of Medicine, USA) |
9:00 am - 9:25 am | Patricia Wittkopp (University of Michigan, USA) "From Mutation to Polymorphism: Evolution of Gene
Expression in Yeast" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Joe Thornton (University of Chicago, USA) "Mechanisms for the Evolution of Transcription Factor
Specificity" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Vincent Lynch (University of Chicago, USA) "Transposable Element Mediated Gene Regulatory Network Innovation" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Diethard Tautz (Max-Planck Institute for Evolutionary Biology, Germany) "De Novo Gene Formation and Adaptation" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Claudia Kutter (Cancer Research UK Cambridge Institute, University of Cambridge, United Kingdom) "Evolution and Regulation of the tRNA-mRNA Interface" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Frank Poelwijk (University of Texas Southwestern Medical Center, USA) "Mapping Higher-Order Epistasis to Explore the Complexity of Protein Sequences" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Evolution of Complexity |
| Discussion Leader: Joanna Masel (University of Arizona, USA) |
7:30 pm - 7:55 pm | Joanna Masel (University of Arizona, USA) "Drift Barriers and Evolvability" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Nicole King (University of California, Berkeley, USA) "Choanoflagellate Colonies, Bacterial Signals, and
Animal Origins" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Chris Adami (Michigan State University, USA) "Exploring the Evolution of Behavior and Intelligence" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Neev Antonovsky (Weizmann Institute of Science, Israel) "Design, Implementation and Evolution of a Fully Functional Calvin Cycle in E. coli" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |