Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Origin of Life, Evolution
and Aging
Discussion Leader: Ivan Matic (INSERM U1001 / Universite Paris Descartes, France)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Nigel Goldenfeld (University of Illinois at Urbana-Champaign, USA)
"Evolutionary Transitions
in the First 1,000,000,000 Years of Life: Emergence of Homochirality and the Genetic
Code"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Tom Kirkwood (Institute for Ageing, Newcastle University, United Kingdom)
"Evolution and the Origins of Aging"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Setting Evolutionary Rates: Mutation and Recombination
Discussion Leader: Olivier Tenaillon (INSERM, France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Daniel Fisher (Stanford University, USA)
"How Much Recombination Is Enough?"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Laurent Duret (University of Lyon, CNRS, France)
"Biased Gene Conversion: The Dark Side of Recombination"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Kirsten Bomblies (John Innes Centre, United Kingdom)
"Causes and Consequences of the Evolution
of Meiosis and Recombination"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
Johan Paulsson (Harvard University, USA)
"Fluctuations and Control of Macromolecules in Bacteria"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Selected from Poster Abstracts: Marina Elez (Pierre and Marie Curie University, France)
"Mutation Dynamics and Fitness Effects Followed in Single Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Selected from Poster Abstracts: Lana Talmane (The University of Edinburgh, United Kingdom)
"The Landscape of Replication-Associated Mutations in Human and Mouse Germlines"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: Chi Xue (University of Illinois at Urbana-Champaign, USA)
"Even Parasites Have Parasites: Oscillatory Population Dynamics of Mobile Genetic Elements in Your Genome"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Susan Rosenberg (Baylor College of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress-Inducible Genetic Variation and Evolution
Discussion Leader: Susan Rosenberg (Baylor College of Medicine, USA)
7:30 pm - 7:50 pm
Thomas Kuhlman (University of Illinois at Urbana-Champaign, USA)
"Real Time Transposable Element Activity
in Live Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Thomas Ferenci (University of Sydney, Australia)
"Non-Linearity Between Inputs and Outputs
in Stress-Induced Mutagenesis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Judith Berman (Tel Aviv University, Israel)
"Eukaryotic Mechanisms of Overcoming Antimicrobial Drug
Stress"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Reuben Harris (Howard Hughes Medical Institute, USA)
"Tumor Evolution by
APOBEC-Catalyzed DNA Deamination"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Non-Genetic Variation and Inheritance
Discussion Leader: Martin Ackermann (ETH Zurich, Switzerland)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Andreas Wagner (University of Zurich , Switzerland)
"On the Role of Mistranslation in Adaptive
Evolution"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Christophe Herman (Baylor College of Medicine, USA)
"Transcription Fidelity
Impedes DNA Break Repair"
10:05 am - 10:15 am
Discussion
10:15 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Selected from Poster Abstracts: Lilach Hadany (Tel Aviv University, Israel)
"Non-Genetic Inheritance and the Evolution of Cooperation"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Selected from Poster Abstracts: Dragan Stajic (Fundacao Calouste Gulbenkian, Instituto Gulbenkian de Ciencia, Portugal)
"The Role of Epigenetic Mechanisms in the Adaptive Evolution"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Naomi Ziv (University of California, San Francisco, USA)
"Molecular Analysis of Bistability in a Eukaryotic Transcriptional Network"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Selected from Poster Abstracts: Xinzhu Wei (University of Michigan, USA)
"A New Theory on the Cause of Genetic Dominance"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Selected from Poster Abstracts: Lei Sun (ETH Zurich, Switzerland)
"Effective Polyploidy Causes Phenotypic Delay and Influences Bacterial Evolvability"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phenotypic Noise and Evolution
Discussion Leader: Christophe Herman (Baylor College of Medicine, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Martin Ackermann (ETH Zurich, Switzerland)
"An Evolutionary
Perspective on Phenotypic Heterogeneity in Microbes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Leor Weinberger (University of California, San Francisco, USA)
"Adaptations for Harnessing 'Noise'
to Control Fate Specification"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Selected from Poster Abstracts: Angela Phillips (Massachusetts Institute of Technology, USA)
"Influenza Evolution Is Modulated by Host Proteostasis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Selected from Poster Abstracts: Joel Stavans (Weizmann Institute of Science, Israel)
"One Day in the Life, Development and Evolution of a One-Dimensional Organism"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Selected from Poster Abstracts: Zoran Marinkovic (Paris Diderot University, France)
"Growth, Differentiation and Self-Organization of S. cerevisiae Colonies in Controlled Spatially Structured Dynamically Changing Environments"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution
of Novelty
Discussion Leader: Joe Thornton (University of Chicago, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Manyuan Long (University of Chicago, USA)
"The Sibling Paradox: Rapid Evolution
of Genetic Systems for Phenotypic Control by New Genes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Shelley Copley (University of Colorado Boulder, USA)
"Promiscuity, Serendipity and Metabolic Innovation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Marie-Anne Felix (Institut de Biologie de l'Ecole Normale Superieure, France)
"Phenotypic Effects of Random Mutation"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Selected from Poster Abstracts: Avihu Yona (Massachusetts Institute of Technology, USA)
"Random Sequences Rapidly Evolve into De Novo Promoters"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Victor Luria (Harvard Medical School, USA)
"Variation and Novelty in Evolution: De Novo Genes Arise and Enable Protein Structural Innovation"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Selected from Poster Abstracts: Krishna Swamy (Institute of Molecular Biology, Academia Sinica, Taiwan)
"Proteatoxic Stress Due to Loss of Interaction Partners Induces Reproductive Isolation in Yeast Hybrids"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Selected from Poster Abstracts: Yu-Ying Hsieh (Harvard University, USA)
"Repurposing the Function of a Meiotic Cohesin Protein in Budding Yeast"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Evolution
of Complexity
Discussion Leader: Marie-Anne Felix (Institut de Biologie de l'Ecole Normale Superieure, France)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Gunter Wagner (Yale University, USA)
"Evolving Complex Body Plans Through Cell Type Diversity: Molecular and Cellular Mechanisms"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Annalise Paaby (Georgia Institute of Technology, USA)
"Conditionally
Functional Variation and the Evolution of Complex Traits"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Joe Thornton (University of Chicago, USA)
"Ancient Mechanisms for the Evolution of a New Molecular Signaling System"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Selected from Poster Abstracts: Tyler Starr (University of Chicago, USA)
"Alternative Evolutionary Histories in the Sequence Space of an Ancient Protein"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Somatic Evolution: Cancer
Discussion Leader: Darryl Shibata (Keck School of Medicine, University of Southern California, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Marco Gerlinger (The Institute of Cancer Research, United Kingdom)
"Dissecting Cancer
Evolution: Patterns,
Dynamics and Clinical
Implications"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Richard White (Memorial Sloan Kettering Cancer Center, USA)
"Error-Prone DNA Polymerases in Melanoma Progression
and Drug Resistance"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Susan Rosenberg (Baylor College of Medicine, USA)
"E. coli Identifies New Cancer
Gene Functions that Promote Evolvability"
10:55 am - 11:05 am
Discussion
11:05 am - 11:15 am
Selected from Poster Abstracts: Muhammad Sufyan Bin Masroni (National University of Singapore, Singapore)
"Regenerable Altruism in Clonal Cancer Cells"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Selected from Poster Abstracts: Cemalettin Bekpen (Max-Planck Institute for Evolutionary Biology, Germany)
"High Copy Number of SPATA31 Genes Correlates with Somatic Mutation Rate and Shorter Life Span in Humans"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Selected from Poster Abstracts: Joanna Masel (University of Arizona, USA)
"Intercellular Competition and the Inevitability of Multicellular Aging"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Alesia McKeown (University of Utah School of Medicine, USA)
"Novel Roles for Retrogenes in Host Immunity"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: Amir Mitchell (University of Massachusetts Medical School, USA)
"Extracellular Stimuli Dynamics Can Undermine Optimal Cell Response: Detrimental Misperception by the MAPK Signaling Network in Yeast"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Replaying
the Tape of Life: Experimental Evolution and Evolutionary Contingency
Discussion Leader: Andrew Murray (Harvard University, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Olivier Tenaillon (INSERM, France)
"The Long-Term Molecular
Fate of Mutator Genomes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Tim Cooper (University of Houston, USA)
"Gene Interactions Cause Repeatable Changes
in E. coli Evolvability"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Michael Desai (Harvard University, USA)
"The Dynamics of Molecular Evolution over 60,000 Generations"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Selected from Poster Abstracts: Yuping Li (Stanford University, USA)
"Understanding Adaptation and Fitness Trade-Offs in Yeast"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure