Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Long Term Laboratory Evolution to Life Elsewhere
7:40 pm - 8:25 pm
"Stellar UV Light and the Origins of Life's Building Blocks"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Dynamics of Phenotypic and Genomic Evolution in a Long-Term Experiment with E. coli "
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Evolutionary Dynamics and Predicting Evolution
9:00 am - 9:20 am
"Phylogenetic Forecasting"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Coevolutionary Dynamics in the Adaptive Immune System"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Observing Evolutionary Dynamics with Renewable Lineage Tracking"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Global Fitness Landscapes of the Shine-Dalgarno Sequence"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"The Evolution of Fitness Effects in a Long-Term Experiment with Bacteria"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Mapping Genome Microevolution in a Human Fungal Pathogen"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Noisy Expression Leads to Faster Adaptive Evolution in a Fluorescent Protein"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Evolution of Developmental Mechanisms
7:30 pm - 8:00 pm
"Molecular Mechanisms Underlying Transcription Circuit Evolution"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Predicting Mutational Routes to New Adaptive Phenotypes"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Additional Layer of Regulation via Convergent Gene Orientation in Yeasts"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Single Cell Tracking of Transcription Factor Dynamics in a Eukaryotic Bistable System"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Speciation and Genetic Divergence
9:00 am - 9:25 am
"The Genomic and Metabolic Making of Yeast Biodiversity"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"A Tail of Tales: The Genetics, Development and Function of Long Tails in Forest Mice"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"An Adaptive Gene Expression Program Activated by a Pervasive Protein-Based Epigenetic Element"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Gene Transfer Across Bacterial Subspecies Rapidly Navigates a Complex Fitness Landscape"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"The Nad+-Dependent Deacetylase Sir2 Enables Evolutionary Adaptations by Regulating Distinct Gene"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Extensive Loss of Cell Cycle and DNA Repair Genes in an Ancient Lineage of Bipolar Budding Yeasts"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Mosaic Evolution of Bacterial Life Cycles"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Pax Somatica: Sequestration of the Soma as a Conflict-Resolution Device"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Dissecting the Role of Aneuploidy During Tumor Evolution"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Evolution of Unstable Genomes: One Step, Two Steps and Many Steps"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Experimental Evolution in Diploid Yeast Using Ultrahigh Resolution Barcodes"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Phenotypic Commonality in Genetically Heterogeneous Aneuploid Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Evolution and Chemical Innovation
9:00 am - 9:20 am
"Leveraging Metabolic Plasticity for Industrial-Scale Production of Green Chemicals"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Impacts of Natural Selection on the Metabolome"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Gene Duplication and Divergence: The Bigger Picture"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Directed Evolution of Extreme Resistance to Ionizing Radiation in Escherichia coli "
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Feed-Forward Regulation Adaptively Evolves via Dynamics Rather than Topology when There Is Intrinsic Noise"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Gradual Incompatibility and Entrenchment Lead to Distinct Molecular Solutions During Parallel Enzyme Evolution"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Secondary Environmental Variation Creates a Shifting Evolutionary Watershed for the Methyl-Parathion Hydrolase Enzyme"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Protein Evolution: Altering the Structure and Function of Molecular Machines
7:30 pm - 7:50 pm
"Evolutionary Constraints in Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mapping the Antigenic Evolution of Influenza Virus"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Engineering Orthogonal Signaling Pathways Reveals the Sparse Occupancy of Sequence Space"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Shared Non-Canonical Substrate Facilitates the Evolution of Drug Export in the Small Multidrug Resistance (Smr) Family of Transporters"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Many but Not All Lineage-Specific Genes Can Be Explained by Limited Sensitivity of Homology Detection"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Evolution: Mechanisms and Forces that Change Genome Structure
9:00 am - 9:20 am
"The Impact of Genome Instability on Adaptation and Antifungal Drug Resistance"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Genetic Determinants of Cooperation in Yeast"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The Dynamics of Innovation in Digital Genomes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"wtf Meiotic Drivers Select for Atypical Meiotic Products"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Evolutionary Adaptation to DNA Replication Stress Reveals Plasticity in Chromosome Metabolism"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"The Role of Aneuploidy in Adaptive Evolution"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Single-Cell Copy Number Variant Detection Reveals the Dynamics and Diversity of Adaptation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Evolution of Disease and the Molecular Basis of Hosts-Pathogen Coevolution
7:30 pm - 7:50 pm
"Eco-Evolutionary Dynamics of Bacteria Colonising the Gut"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"An Evolution Guided Approach to Enhance Antiviral Specificity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Transitions in Fungal Sexual Reproduction via Genome Reorganization"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Oral Vaccines Can Set an Evolutionary Trap for Salmonella Typhimurium"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Competition for Iron in Legionella and Their Amoeba Hosts: A New Model of Host-Microbe Co-Evolution"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure