Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Long Term Laboratory Evolution to Life Elsewhere
Discussion Leader: Olivier Tenaillon (INSERM, France)
7:40 pm - 8:25 pm
Dimitar Sasselov (Origins of Life Initiative, Harvard University, USA)
"Stellar UV Light and the Origins of Life's Building Blocks"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Richard Lenski (Michigan State University, USA)
"Dynamics of Phenotypic and Genomic Evolution in a Long-Term Experiment with E. coli "
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Evolutionary Dynamics and Predicting Evolution
Discussion Leader: Richard Lenski (Michigan State University, USA)
9:00 am - 9:20 am
Boris Shraiman (Kavli Institute for Theoretical Physics, USA)
"Phylogenetic Forecasting"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Armita Nourmohammad (Max Planck Institute for Dynamics and Self-Organization, Germany)
"Coevolutionary Dynamics in the Adaptive Immune System"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Michael Desai (Harvard University, USA)
"Observing Evolutionary Dynamics with Renewable Lineage Tracking"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Hsin-Hung Chou (National Taiwan University, Taiwan)
"Global Fitness Landscapes of the Shine-Dalgarno Sequence"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Alejandro Couce (Imperial College London, United Kingdom)
"The Evolution of Fitness Effects in a Long-Term Experiment with Bacteria"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Iuliana Ene (Brown University, USA)
"Mapping Genome Microevolution in a Human Fungal Pathogen"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Shraddha Karve (University of Zurich, Switzerland)
"Noisy Expression Leads to Faster Adaptive Evolution in a Fluorescent Protein"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Judith Berman (Tel Aviv University, Israel)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Evolution of Developmental Mechanisms
Discussion Leader: Teresa Davoli (New York University School of Medicine, USA)
7:30 pm - 8:00 pm
Alexander Johnson (University of California, San Francisco, USA)
"Molecular Mechanisms Underlying Transcription Circuit Evolution"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Paul Rainey (Max Planck Institute for Evolutionary Biology, Germany)
"Predicting Mutational Routes to New Adaptive Phenotypes"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Ingrid Lafontaine (UMR7141, CNRS / Sorbonne Université, France)
"Additional Layer of Regulation via Convergent Gene Orientation in Yeasts"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Naomi Ziv (University of California, San Francisco, USA)
"Single Cell Tracking of Transcription Factor Dynamics in a Eukaryotic Bistable System"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Speciation and Genetic Divergence
Discussion Leader: Shelley Copley (University of Colorado Boulder, USA)
9:00 am - 9:25 am
Chris Hittinger (University of Wisconsin-Madison, USA)
"The Genomic and Metabolic Making of Yeast Biodiversity"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Hopi Hoekstra (Harvard University, USA)
"A Tail of Tales: The Genetics, Development and Function of Long Tails in Forest Mice"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Daniel Jarosz (Stanford University, USA)
"An Adaptive Gene Expression Program Activated by a Pervasive Protein-Based Epigenetic Element"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Berenike Maier (University of Cologne, Germany)
"Gene Transfer Across Bacterial Subspecies Rapidly Navigates a Complex Fitness Landscape"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Laura Rusche (University at Buffalo, USA)
"The Nad+-Dependent Deacetylase Sir2 Enables Evolutionary Adaptations by Regulating Distinct Gene"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Jacob Steenwyk (Vanderbilt University, USA)
"Extensive Loss of Cell Cycle and DNA Repair Genes in an Ancient Lineage of Bipolar Budding Yeasts"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Jordi van Gestel (University of Zurich, Switzerland)
"Mosaic Evolution of Bacterial Life Cycles"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Somatic Evolution
Discussion Leader: Michael Desai (Harvard University, USA)
7:30 pm - 7:50 pm
David Haig (Harvard University, USA)
"Pax Somatica: Sequestration of the Soma as a Conflict-Resolution Device"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Teresa Davoli (New York University School of Medicine, USA)
"Dissecting the Role of Aneuploidy During Tumor Evolution"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Cheng-Zhong Zhang (Dana Farber Cancer Institute, USA)
"Evolution of Unstable Genomes: One Step, Two Steps and Many Steps"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Monica Sanchez (Stanford University, USA)
"Experimental Evolution in Diploid Yeast Using Ultrahigh Resolution Barcodes"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Hung-Ji Tsai (Johns Hopkins University School of Medicine, USA)
"Phenotypic Commonality in Genetically Heterogeneous Aneuploid Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Evolution and Chemical Innovation
Discussion Leader: Isabel Gordo (Instituto Gulbenkian de Ciencia, Portugal)
9:00 am - 9:20 am
Annie Tsong (Amyris, USA)
"Leveraging Metabolic Plasticity for Industrial-Scale Production of Green Chemicals"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Balazs Papp (Biological Research Center, Hungarian Academy of Sciences, Hungary)
"Impacts of Natural Selection on the Metabolome"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Shelley Copley (University of Colorado Boulder, USA)
"Gene Duplication and Divergence: The Bigger Picture"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Steven Bruckbauer (University of Wisconsin-Madison, USA)
"Directed Evolution of Extreme Resistance to Ionizing Radiation in Escherichia coli "
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Joanna Masel (University of Arizona, USA)
"Feed-Forward Regulation Adaptively Evolves via Dynamics Rather than Topology when There Is Intrinsic Noise"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Charlotte Miton (University of British Columbia, Canada)
"Gradual Incompatibility and Entrenchment Lead to Distinct Molecular Solutions During Parallel Enzyme Evolution"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Nobuhiko Tokuriki (University of British Columbia, Canada)
"Secondary Environmental Variation Creates a Shifting Evolutionary Watershed for the Methyl-Parathion Hydrolase Enzyme"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Protein Evolution: Altering the Structure and Function of Molecular Machines
Discussion Leader: Balazs Papp (Biological Research Center, Hungarian Academy of Sciences, Hungary)
7:30 pm - 7:50 pm
Kimberly Reynolds (University of Texas Southwestern Medical Center, USA)
"Evolutionary Constraints in Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jesse Bloom (Fred Hutchinson Cancer Research Center, USA)
"Mapping the Antigenic Evolution of Influenza Virus"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Michael Laub (Massachusetts Institute of Technology / Howard Hughes Medical Institute, USA)
"Engineering Orthogonal Signaling Pathways Reveals the Sparse Occupancy of Sequence Space"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Christian Macdonald (University of Michigan, USA)
"A Shared Non-Canonical Substrate Facilitates the Evolution of Drug Export in the Small Multidrug Resistance (Smr) Family of Transporters"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Caroline Weisman (Harvard University, USA)
"Many but Not All Lineage-Specific Genes Can Be Explained by Limited Sensitivity of Homology Detection"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Evolution: Mechanisms and Forces that Change Genome Structure
Discussion Leader: Kimberly Reynolds (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:20 am
Anna Selmecki (University of Minnesota Medical School, USA)
"The Impact of Genome Instability on Adaptation and Antifungal Drug Resistance"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tzachi Pilpel (Weizmann Institute of Science, Israel)
"Genetic Determinants of Cooperation in Yeast"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Carole Knibbe (INSA Lyon, France)
"The Dynamics of Innovation in Digital Genomes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Maria Bravo Nunez (Stowers Institute for Medical Research, USA)
"wtf Meiotic Drivers Select for Atypical Meiotic Products"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Marco Fumasoni (Harvard University, USA)
"Evolutionary Adaptation to DNA Replication Stress Reveals Plasticity in Chromosome Metabolism"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Yoav Ram (IDC Herzliya, Israel)
"The Role of Aneuploidy in Adaptive Evolution"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
David Gresham (New York University, USA)
"Single-Cell Copy Number Variant Detection Reveals the Dynamics and Diversity of Adaptation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Evolution of Disease and the Molecular Basis of Hosts-Pathogen Coevolution
Discussion Leader: Anna Selmecki (University of Minnesota Medical School, USA)
7:30 pm - 7:50 pm
Isabel Gordo (Instituto Gulbenkian de Ciencia, Portugal)
"Eco-Evolutionary Dynamics of Bacteria Colonising the Gut"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Harmit Malik (Fred Hutchinson Cancer Research Center, USA)
"An Evolution Guided Approach to Enhance Antiviral Specificity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Joseph Heitman (Duke University, USA)
"Transitions in Fungal Sexual Reproduction via Genome Reorganization"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Mederic Diard (Biozentrum, Switzerland)
"Oral Vaccines Can Set an Evolutionary Trap for Salmonella Typhimurium"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Tera Levin (Fred Hutchinson Cancer Research Center, USA)
"Competition for Iron in Legionella and Their Amoeba Hosts: A New Model of Host-Microbe Co-Evolution"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure