Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Principles and Mechanisms of Genome Evolution
Discussion Leader: Daniel Jarosz (Stanford University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Rong Li (Mechanobiology Institute, National University of Singapore, Singapore)
"Aneuploidy: Alteration of Chromosome Stoichiometry as a Mechanism of Phenotypic Variation Driving Cellular Evolution"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Dmitri Petrov (Stanford University, United States)
"Genomic Basis of Rapid and Strongly Fluctuating Seasonal Selection in Drosophila"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanistic Control of Molecular Evolution: A Tale of Mutation and Recombination Rates
Discussion Leader: Ivan Matic (Université Paris Cité, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Jade Wang (University of Wisconsin-Madison, United States)
"Evolutionary Constraint and Flexibility in Bacterial Stress Resistance"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Adi Stern (Tel Aviv University, Israel)
"Evolution on the Fast-Track: Social and Non-Social Dynamics in an RNA Phage"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:50 am
Wayne Wahls (University of Arkansas for Medical Sciences, United States)
"Molecular Mechanisms for Environmentally Induced and Evolutionarily Rapid Redistribution (Plasticity) of Meiotic Recombination"
10:50 am - 10:55 am
Discussion
10:55 am - 11:05 am
Arvind Murugan (University of Chicago, United States)
"Evolution of Kinetic Proofreading"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Einat Hazkani-Covo (The Open University of Israel, Israel)
"Protein Innovation Through Template Switching in the Saccharomyces cerevisiae Lineage"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Alejandro Couce (Universidad Politécnica de Madrid (SPAIN), Spain)
"Evolutionary Consequences of Strongly Biased Mutation Rates in Bacteria"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Marco Fumasoni (Instituto Gulbenkian de Ciência (IGC), Portugal)
"Predicting Evolutionary Repair: Adapting to DNA Replication Stress in Different Circumstances"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Michael Overton (University of California, San Diego, United States)
"Upper Bound on the Mutational Burden Imposed by a CRISPR-Cas9 Gene Drive Element"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Tera Levin (University of Pittsburgh, United States)
"Dynamics of Bacterial Virulence Gene Evolution via Horizontal Gene Transfer"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Dawn Thompson (LifeMine Therapeutics , United States) and Nathan Springer (Bayer Crop Sciences / University of Minnesota, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Determinants of Atypical Heredity
Discussion Leader: Mia Levine (University of Pennsylvania, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Sarah Zanders (Stowers Institute for Medical Research, United States)
"wtf Evolution"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Upasna Sharma (University of California, Santa Cruz, United States)
"Intergenerational Epigenetic Inheritance by Sperm Small RNAs"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Didier Mazel (Institut Pasteur, France)
"Genetic Drivers of Chromosomal Integron Stability"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Lews Caro (University of Washington, Seattle, United States)
"The peel-1/zeel-1 Selfish Element Coopts a Conserved Membrane Protein to Create a Toxic Cation Channel"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Evolution: Lessons From Deep Scans and Large Database
Discussion Leader: Nobuhiko Tokuriki (University of British Columbia, Canada)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Martin Weigt (Sorbonne Universite, France)
"Protein Evolution in Sequence Landscapes: From Data to Models and Back"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Douglas Fowler (University of Washington, United States)
"Towards a Comprehensive Atlas of Variant Effects"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Marc Ostermeier (Johns Hopkins University, United States)
"Collateral Fitness Effects: Prevalence and Mechanisms"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Alaksh Choudhury (ESPCI, France)
"The Discovery of Modules in the RNA Polymerase Associated with Global Traits Using Deep Mutational Scanning"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Dia Ghose (Massachusetts Institute of Technology, United States)
"Marginal Specificity in Protein Interactions Constrains Evolution of a Paralogous Family"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Tyler Starr (University of Utah, United States)
"Evolution of SARS-CoV-2 and Related Bat Coronaviruses"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Ayse Erdogan (The University of British Columbia, Canada)
"Neutral Drift and Threshold Selection Promote Phenotypic Variation"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Joe Thornton (University of Chicago, United States)
"High-Order Epistasis in Proteins? The Landscape of Evolutionary Contingency Remains Largely Stable Over Time"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Drugs, Germs and Genes: Evolution in Response to Stress and Drugs
Discussion Leader: Jan Michiels (KU Leuven, Belgium)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Nathalie Balaban (Hebrew University, Israel)
"Evolutionary Consequences of a Disrupted Cellular State"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Pleuni Pennings (San Francisco State University, United States)
"Quantifying Evolution and Transmission of Drug Resistance in Bacteria"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Jing Lin Xie (Stanford University, United States)
"Pararesistance: a Non-Genetic Mechanism of Antifungal Drug Resistance"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Mariana Noto Guillen (University of Massachusetts Medical School, United States)
"Alternative Strategies for Bacterial Adaptation Against Host-Targeted Drugs"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Susan Rosenberg (Baylor College of Medicine, United States)
"Drugging Evolution of Antibiotic Resistance at a Regulatory-Network Hub"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolism Evolution, Natural and Engineered Innovations
Discussion Leader: Anne-Ruxandra Carvunis (University of Pittsburgh, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Markus Ralser (Charité Universitätsmedizin Berlin, Germany)
"Cell-Cell Metabolite Exchange Interactions and Their Role in Stress Response and Cellular Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Julia Vorholt (ETH Zurich, Switzerland)
"Engineering and Long-Term Experimental Evolution of One Carbon Metabolism"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Bas Teusink (Vrije Universiteit Amsterdam, The Netherlands)
"Optimal Resource Allocation in Unicellular Organisms: Theory and the Evidence"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Manyuan Long (The University of Chicago, United States)
"The Origin of Genes from Scratch under Sexual Conflict"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Maria Mascotti (University of Groningen, The Netherlands)
"Emergence and Diversification of Function in Flavoprotein Monooxygenases"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Idan Frumkin (Massachusetts Institute of Technology, United States)
"Random Proteins Provide Evolutionary Novelty by interaction with Diverse Cellular Pathways"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Della Fixsen (UC Boulder, United States)
"Evolution of Novel Metabolic Pathways"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Etthel Windels (ETH Zürich, Switzerland)
"Antibiotic Dose and Nutrient Availability Differentially Drive the Evolution of Antibiotic Resistance and Persistence"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Evolution Beyond Single Nucleotide Variants: The Evolution of Genome Architecture
Discussion Leader: Anna Selmecki (University of Minnesota Medical School, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Jef Boeke (Institute for Systems Genetics, NYU Langone Health, United States)
"Writing Genomes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Dawn Thompson (LifeMine Therapeutics , United States)
"Microbial Biosynthetic Gene Cluster Evolution: from Chemical Warfare to Host Adaptation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Audrey Gasch (University of Wisconsin-Madison, United States)
"Genetic Determinants of Aneuploidy Stress in Budding Yeast"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Yoav Ram (Tel Aviv University, Israel)
"Aneuploidy Can be an Evolutionary Detour on the Path to Genetic Adaptation"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Epistasis and The Evolution of Complex Traits
Discussion Leader: Nathan Springer (Bayer Crop Sciences / University of Minnesota, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Emma Farley (University of California San Diego, United States)
"Affinity-Optimizing Enhancer Variants Disrupt Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Mark Siegal (New York University, United States)
"Uncovering Genetic Interactions Causing Natural Trait Variation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Gael Yvert (CNRS and ENS de Lyon, France)
"Genetics of Cell-to-Cell Variability"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Angela Phillips (University of California, San Francisco, United States)
"Evolutionary Paths to Broadly Neutralizing Antibodies"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Joao Ascensao (UC Berkeley, United States)
"Quantifying the Local Adaptive Landscape of a Nascent Bacterial Community"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Arnaud N'Guessan (University of Toronto, Canada)
"Refining the Resolution of the Yeast Genotype-Phenotype Map Using Single-Cell RNA-Sequencing"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Grant Kinsler (University of Pennsylvania, United States)
"Phenotypic and Evolutionary Properties of Large-Effect Adaptive Mutations Isolated From a Two-Step Adaptive Walk"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Pétra Vande Zande (University of Minnesota, United States)
"Step-Wise Adaptation to Drug in Candida albicans Involving Large-Scale Copy Number Amplification Followed by Short-Tract Loss of Heterozygosity."
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Somatic and Cancer Evolution
Discussion Leader: Dmitri Petrov (Stanford University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Ashby Morrison (Stanford University, United States)
"Epigenetic Regulation of Environmental Carcinogen Susceptibility"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Jordan Compton (Victoria University of Wellington, New Zealand)
"An Unusual Archaeal Phosphofructokinase Sheds Light on The Evolution of Specificity and Horizontal Transfer of Allosteric Enzymes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Ran Friedman (Linnaeus University, Sweden)
"Evolution of Resistance to Targeted Therapies in Leukaemias"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Francesca Macaluso (IFOM ETS, Italy)
"Laboratory Evolution Experiments Uncover the Emergence of Resistance upon Microtubule Hyper-stabilization"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure