Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Adversity Shapes Diversity
Selective pressure can drive evolution. This session explores how deleterious mutations and antagonistic interactions give rise to biological innovation.
Discussion Leader: Anna Selmecki (Creighton University School of Medicine, USA)
3:45 pm - 4:00 pm
Karoly Kovacs (Biological Research Centre (BRC), Hungarian Academy of Sciences, Hungary)
"Compensated Deleterious Mutations as Drivers of Morphological Evolution"
4:00 pm - 4:05 pm
Discussion
4:05 pm - 4:20 pm
Sriram Srikant (Harvard University, USA)
"Evolution of Substrate Selectivity in ABC Exporters with the Fungal Mating System"
4:20 pm - 4:25 pm
Discussion
4:25 pm - 4:30 pm
General Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Uniting Mechanistic and Evolutionary Biology: Uncovering Molecular Mechanisms that Drive Evolutionary Processes
Molecular biological approaches have become critical to understanding evolution. This session will highlight research into the molecular mechanisms involved in evolutionary processes such as mutation, inheritance, phenotypic plasticity, and more.
Discussion Leader: Joseph Heitman (Duke University, USA)
7:30 pm - 7:45 pm
Jose Aguilar-Rodriguez (Stanford University, USA)
"Pervasive Modulation of a Natural Genotype-Phenotype Map by Global Epistatic Modifiers"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Grace Avecilla (New York University, USA)
"A Strong Selection, Strong Mutation Regime Drives Predictable Copy Number Variant Dynamics in the Early Stages of Adaptive Evolution"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Oliver Caspari (Institut de Biologie Physico-Chimique (UMR7141) / CNRS / Sorbonne Université, France)
"Evidence for an Antimicrobials Origin of Organelle Transit Peptides"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Della Fixsen (University of Utah, USA)
"Viruses Capture Host Genes via LINE-1 Mediated Retrotransposition in Infected Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Kyle Fowler (University of California, San Francisco, USA)
"Relaxed Contingency Due to Genetic Code Ambiguity Promotes Protein Evolution"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jacob Peter (University of Southern Mississippi, USA)
"Role of RNA Dependent RNA Polymerase in Amphioxus RNAi Pathway"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Uniting Mechanistic and Evolutionary Biology: Using Evolutionary Trajectories and Standing Variation to Understand Molecular Processes
Viewing molecular and cellular processes within their evolutionary contexts can reveal key mechanistic information. This session will highlight research that harnesses the power of experimental evolution, phylogenetic reconstructions, and standing genetic variation to gain insight into molecular systems.
Discussion Leader: Shelley Copley (University of Colorado Boulder, USA)
9:00 am - 9:15 am
Adair Borges (University of California, San Francisco, USA)
"CRISPR vs Anti-CRISPR(s): Phages Employ Diverse Strategies to Neutralize Bacterial Immunity"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Sarah Hilton (University of Washington, USA)
"Developing Statistical, Phylogenetic Methods to Compare Selection in the Lab to Selection in Nature"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Katherine Lawrence (Harvard University / Massachusetts Institute of Technology, USA)
"Comprehensive Measurements of Genetic Architecture in a Diverse Yeast Cross Through Barcoded Bulk QTL Mapping"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Margaux Pinney (Stanford University, USA)
"A Simple Evolutionary Mechanism for Reciprocal Enzymatic Temperature Adaptation from Substitution of a Single Hydrogen Bond"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Andrew Schober (University of Texas Southwestern Medical Center, USA)
"A Two-Enzyme Adaptive Unit Within Bacterial Folate Metabolism"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Grant Kinsler (Stanford University, USA)
"Uncovering the Fitness-Relevant Phenotypes of Microbes Adapting to Novel Environments"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Evolutionary Mechanisms in Health and the Environment
Increased cross-talk between mechanistic and evolutionary biology has the potential improve our understanding of key evolutionary challenges in preserving human health and the environment. This session will highlight translational research combining mechanistic and evolutionary approaches.
Discussion Leader: Chris Hittinger (University of Wisconsin-Madison, USA)
1:30 pm - 1:45 pm
Kyle Card (Michigan State University, USA)
"Predictability and Contingency in the Evolution of Antibiotic Resistance After Multiple Decades of Relaxed Selection"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Heer Mehta (Rice University, USA)
"The Unexpected Role of a Dihydropteroate Synthase (folP) Homolog in the Evolution of Nocardia to Co-Trimoxazole"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Etthel Windels (University of Leuven, Belgium)
"Genetic Drift and the Antibiotic Treatment Schedule Determine Evolutionary Trajectories Toward High Antibiotic Resistance and Persistence"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
