Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: The Genotype-Phenotype-Phenotype-Phenotype Map
Discussion Leader: Michelle Hays (Stanford University, United States)
3:45 pm - 4:25 pm
Kerry Geiler-Samerotte (Arizona State University, United States)
"The Genotype-Phenotype-Phenotype-Phenotype Map"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanistic Causes in Molecular Evolution
Discussion Leader: Anna Selmecki (University of Minnesota Medical School, United States)
7:30 pm - 7:45 pm
Caroline Zeidler (Max-Planck Institut for Marine Microbiology, Germany)
"Bioplastic-Eating Animals: The Ability to Degrade Polyhydroxyalkanoates is Widespread in the Animal Kingdom"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
María Angélica Bravo Núñez (Harvard University, United States)
"The Role of Meiotic Factors in Ploidy Dynamics"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jordan Compton (Victoria University of Wellington, New Zealand)
"An Unusual Archaeal Phosphofructokinase Sheds Light on the Evolution of Specificity and Horizontal Transfer of Allosteric Enzymes"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Pieter Spealman (New York University, United States)
"Adaptive Modulation of Copy-Number Variant Gene Expression at Multiple Levels of Gene Regulation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Cara Brand (University of Pennsylvania, United States)
"Cross-Species Incompatibility Between a DNA Satellite and the Drosophila Spartan Homolog Poisons Germline Genome Integrity"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Shaili Mathur (Stanford University, United States)
"Order Matters: Decoupling the Contributions of Transitions and Growth to Fitness in Fluctuating Environments"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Chance, Necessity, and Contingency in Molecular Evolution
Discussion Leader: Tyler Starr (University of Utah, United States)
9:00 am - 9:15 am
Jaeda Patton (University of Chicago, United States)
"Intermolecular Deep Mutational Scanning Reveals Biased Accessibility of Molecular Phenotypes in an Ancient Genotype-Phenotype Landscape"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Christopher Jakobson (Stanford University School of Medicine, United States)
"Evolutionary Influence of the Hsp90 Chaperone Network is Driven by Regulatory Variation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Kara Schmidlin (Arizona State University, United States)
"Understanding the Likelihood of Evolutionary Tradeoffs Among Drug Resistant Mutations Using a Large Population of Barcoded Yeast"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Lucile Vigué (Inserm DRPA05, INSERM DR Paris IDF Centre Nord (P5), France)
"Predicting the Effect of Mutations to Investigate Recent Events of Selection Across 60,472 Escherichia coli Strains"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Ryan Fritts (University of Colorado Boulder, United States)
"Genomic Context and the Collateral Consequences of Gene Duplication/Amplification"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Emily Lau (University of California, Santa Barbara, United States)
"Predictable Genetic Recruitment in the Convergent Evolution of Bioluminescent Substrate Storage in Fireflies, Sea Pansies, and Ostracods"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Understanding Evolutionary Mechanisms to Address Modern Challenges
Discussion Leader: Olivier Tenaillon (INSERM, France)
1:30 pm - 1:45 pm
Alief Moulana (Harvard University, United States)
"Navigating the SARS-CoV-2 Omicron's Spike Protein Landscapes"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Xin Zhou (University of Minnesota, United States)
"Single-Cell Detection of Copy Number Change in Candida Albicans Reveals Novel Mechanisms of Increased Competitive Fitness In vitro and In vivo"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Niclas Nordholt (Federal Institute for Materials Research and Testing (BAM), Germany)
"The Disinfectant Glutaraldehyde Induces Antibiotic Tolerance Underpinned by a Disrupted Cellular State and Heterogenous Regrowth Dynamics"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes