SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | LYMPHANGIOGENESIS - BASIC MECHANISMS |
| Discussion Leader: Christer Betsholtz (Stockholm) |
7:30 pm - 7:50 pm | Peter Carmeliet (Leuven)
"Fishing and frogging for lymph-angiogenic genes" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Stefan Schulte-Merker (Utrecht) "Lymphangigogenesis in the zebrafish - dose dependent effects of VEGFR signaling" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Brant M. Weinstein (Bethesda, MD) "Lymphatic development in the zebrafish" |
8:50 pm - 9:00 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LYMPHATIC ENDOTHELIUM |
| Discussion Leader: Tatiana Petrova (Helsinki) |
9:00 am - 9:20 am | Elisabetta Dejana (Milan)
"The molecular organization of lymphatic intercellular junctions" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Lena Claesson-Welsh (Uppsala)
"VEGF receptor function in the lymphatic endothelium" |
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Hellmut Augustin (Freiburg)
"Cell biology of lymphatic endothelium" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Salvatore Oliviero (Siena)
"VEGFR-3 signaling" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Pirjo Laakkonen (Helsinki) "Peptide targeting of lymph vessels" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Presentations selected from poster abstracts including fellowship/award presentations |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | DEVELOPMENT OF THE LYMPHATIC VASCULAR SYSTEM |
| Discussion Leader: Peter Carmeliet (Leuven) |
5:30 pm - 5:50 pm | Guillermo Oliver (Memphis, TN)
"Cellular and Molecular Mechanism Regulating the Development of the Lymphatic Vasculature" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Michael Detmar (Zurich) "Molecular control of lymphangiogenesis" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Anne Eichmann (Paris)
"Neural guidance genes in lymphangiogenesis" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Jan Kitajewski (New York, NY)
"Notch regulates VEGFR-3 in vascular development" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MATURATION OF THE LYMPHATIC VESSELS |
| Discussion Leader: Anne Eichmann (Paris) |
9:00 am - 9:20 am | Christer Betsholtz (Stockholm)
"Perivascular cell biology and genomics" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Gavin Thurston (Tarrytown, NY)
"Angiopoietins in the growth and maintenance of blood and lymphatic vessels" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Tatiana Petrova (Helsinki)
"Transcriptional control of lymphatic vessel maturation" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Gou Young Koh (Daejon) "Role of angiogenic factors in remodeling of blood and lymphatic vessels" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Laura Benjamin (Boston) "RhoB regulation of Lymphatic Development" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Presentations selected from poster abstracts including fellowship/award presentations |
12:00 pm - 12:15 pm | Tuomas Tammela (Helsinki) "Engineering New Molecular Forms of VEGF-C for Optimal Treatment of Lymphedema" |
12:15 pm - 12:30 pm | Joseph Rutkowski (Lausanne) "Secondary Lymphedema in the Mouse Tail: Lymphatic Hyperplasia, VEGF-C Upregulation and the Protective Role of MMP-9" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | THE INTERSTITIUM, LYMPH FORMATION AND PROPULSION |
| Discussion Leader: David Bates (Bristol) |
5:30 pm - 5:50 pm | Melody Swartz (Lausanne)
"Autologous chemotaxis: How lymphatic function helps drive cell homing into lymphatics" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Geert Schmid-Schönbein (San Diego, CA)
"What needs to be carried: The inflammatory side of lymphatic fluid" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | David Zawieja (College Station, TX)
"Mechanisms regulating lymphatic contraction and lymph flow" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Helge Wiig (Bergen)
"Role of the interstitium and lymphatics in fluid volume regulation" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LYMPHATIC METASTASIS |
| Discussion Leader: Michael Detmar (Zurich) |
9:00 am - 9:20 am | Marc Achen (Melbourne) "Molecular control of lymphatic metastasis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Gerhard Christofori (Basel) "Distinct Mechanisms of Tumor Metastasis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Rakesh Jain (Boston, MA) "Dissecting steps of lymphatic metastasis" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Yihai Cao (Stockholm) "Regulation of lymphangiogenesis by multiple growth factors" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Mihaela Skobe (New York, NY) "Lymphatic metastasis and its inhibition" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Alanna Ruddell (Seatlle, WA) "Functional expansion of lymph node lymphatics in the formation of metastatic tumors" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Judith Varner (San Diego, CA) "Integrin a4b1 mediated lymph node lymphangiogenesis promotes tumor metastasis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | LYMPHATIC VESSELS IN INFLAMMATION |
| Discussion Leader: Elisabetta Dejana (Milan) |
5:30 pm - 5:50 pm | Dontscho Kerjaschki (Vienna)
"How inflammatory lymphangiogenesis is orchestrated" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Donald McDonald (San Fransisco, CA)
"Cellular actions of inhibitors of lymphangiogenesis and angiogenesis" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Masabumi Shibuya (Tokyo)
"Involvement of VEGFR-1 in lymphangiogenesis in vivo" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | David Jackson (Oxford)
"Regulating cellular traffic in inflamed lymphatics" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PATHOGENESIS OF LYMPHATIC VASCULAR DISEASE |
| Discussion Leader: Dontscho Kerjaschki (Vienna) |
9:00 am - 9:20 am | Miikka Vikkula (Brussels)
"Phenotypic variability in VEGFR3-caused lymphedema" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Peter Mortimer (London)
"Refining the phenotype and mechanisms of oedema in genotyped lymphoedema" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Stanley Rockson (Stanford, CA)
"From Bedside to Bench: Molecular Pathogenesis in Experimental Acute Lymphedema" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | David Bates (Bristol)
"Mechanisms underlying lymphatic pathologies in cancer" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Joerg Wilting (Goettingen) "Development and Malformation of Lymph Vessels" |
11:50 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | THERAPEUTIC ASPECTS |
| Discussion Leader: Donald McDonald (San Francisco) |
5:30 pm - 5:50 pm | Bronek Pytowski (New York, NY)
"In vivo effects of antagonist monoclonal antibodies to VEGFR-3" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Seppo Yla-Herttuala (La Jolla, CA)
"Possibilities to grow lymphatic vessels in vivo with local gene transfer" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Sirpa Jalkanen (Turku) "Targeting mechanisms of cell traffic within the lymphatics" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Achim Hoerauf (Bonn) "Targeting of Wolbachia Endosymbionts in Filarial Worms with Doxycycline Reduces Plasma VEGF-C/sVEGFR-3 and Improves Pathology in Lymphatic Filariasis" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Claus Cursiefen (Erlangen) "Inhibition of inflammatory lymphangiogenesis in the cornea by blocking integrin alpha 5" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |