SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | GROWTH FACTOR MECHANISMS AND STEM CELLS IN LYMPHANGIOGENESIS |
| Discussion Leader: Guillermo Oliver (St. Jude Children's Research Hospital, Memphis) |
7:40 pm - 8:10 pm | Kari Alitalo (University of Helsinki, Finland)
"Growth factor and signaling pathways for lymphangiogenesis and tumor progression" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Michael Detmar (Swiss Federal Institute of Technology, Zurich)
"Molecular pathways mediating lymphatic vessel formation and differentiation" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Gou Young Koh (Korea Advanced Institute of Science and Technology, Daejeon)
"Dysfunctional and functional lymphangiogenesis during tumor progression" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | TRANSCRIPTIONAL REGULATION OF ADIPOGENESIS AND LYMPHANGIOGENESIS |
| Discussion Leader: Brant Weinstein (National Institute of Child Health and Human Development, Washington DC) |
9:00 am - 9:20 am | Evan Rosen (Harvard Medical School)
"New directions in adipocyte development" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Guillermo Oliver (St. Jude Children's Research Hospital, Memphis)
"Prox1 plays multiple roles in developmental and adult lymphangiogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Peter Koopman (The University of Queensland, Brisbane)
"Sox transcription factors and their role in lymphangiogenesis" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Tetsuro Watabe (University of Tokyo)
"Regulation of Prox1-mediated lymphatic differentiation of endothelial cells by transcriptional regulators" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Dieter Maurer (Medical University of Vienna)
"Transcriptional profiling of microvessels identifies molecules involved in leukocyte and cancer cell migration" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Frontier Presentation: Young-sup Yoon (Tufts University School of Medicine)
"Successful culture isolation of bone marrow-derived lymphatic endothelial progenitor cells" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Frontier Presentation: Young Ryun Cha (National Institute of Health)
"Forward-genetic screen in zebrafish for identifying lymphangiogenesis genes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | LYMPHATIC VASCULATURE IN IMMUNITY |
| Discussion Leader: Dieter Maurer (Medical University of Vienna) |
7:30 pm - 7:55 pm | Thorsten Mempel (Harvard Medical School)
"Intravital Immunology: Initiation of immune responses to lymph-borne antigens" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Gwendalyn J. Randolph (Mt. Sinai School of Medicine)
"Dendritic cell migration to lymph nodes through lymphatic vessels" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | David Jackson (University of Oxford)
"Regulation of lymphatic endothelial transmigration" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Frontier Presentation: Suvendu Das (Mt. Sinai School of Medicine)
"Inflamed lymphatic endothelium facilitates tumor metastasis via CCL-1/CCR8-dependent mechanism" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SIGNAL TRANSDUCTION, JUNCTIONS, AND CONTRACTILE PROTEINS IN LYMPHATICS |
| Discussion Leader: Taija Mäkinen (Cancer Research UK London Research Institute, London) |
9:00 am - 9:20 am | Lena Claesson-Welsh (Uppsala University)
"Differential regulation of the lymphatic proteome by VEGF receptors 2 and 3" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Mark Kahn (University of Pennsylvania, Philadelphia)
"How blood shapes lymphatics" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Hellmut G. Augustin (German Cancer Research Center, Heidelberg)
"Molecular and functional analysis of lymphangiogenic endothelial cells" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Donald McDonald (University of California San Francisco)
"Specialized intercellular junctions in the endothelium of initial lymphatics" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Mariappan Muthuchamy (Texas A&M University Health Science Center)
"Unique contractile protein composition and contractile function of lymphatic vessels" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Frontier Presentation: Kathleen Caron (University of North Carolina)
"Adrenomedullin signaling is necessary for lymphatic vascular development" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Frontier Presentation: Rawad Mounzer (Yale University)
"Lymphotoxin in inflammation-induced lymphangiogenesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | LYMPHATIC VESSEL MORPHOGENESIS AND MATURATION |
| Discussion Leader: David Jackson (University of Oxford) |
7:30 pm - 7:50 pm | Brant Weinstein (National Institute of Child Health and Human Development, Washington DC)
"Studying early lymphatic development using the zebrafish" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Toshio Ohhashi and Yoshiko Kawai (Shinshu University School of Medicine)
"Microenvironmental properties for metastatic carcinoma cells in sentinel lymph node: with special reference to molecular profiling of human lymphatic endothelial cells interacted with the carcinoma cells" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Anne Eichmann (Collêge de France, Paris)
"Axon guidance receptors in lymph/angiogenesis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Taija Mäkinen (Cancer Research UK London Research Institute)
"Mechanisms of lymphatic remodeling" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LYMPHATIC METASTASIS |
| Discussion Leader: Kari Alitalo (University of Helsinki) |
9:00 am - 9:20 am | Dontscho Kerjaschki (Medical University Vienna)
"Intametastatic Carcinosis in Human Carcinomas: From Morphology to Mechanisms" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Marc Achen (Ludwig Institute for Cancer Research, Melbourne)
"Activation of lymphangiogenic growth factors in cancer" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Tim Padera (Harvard Medical School, Boston)
"Lymphangiogenesis and lymphatic letastasis - new insights from intravital microscopy" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Judith Varner (University of California San Diego)
"Integrin regulation of lymphangiogenesis and tumor metastasis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Camilla Norrmen (University of Helsinki)
"Foxc2 and mechanisms of lymphatic collecting vessel formation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Frontier Presentation: Imke Albrecht (Center of Biomedicine, University of Basel)
"Transcriptional profiling of tumor-derived lymphatic endothelial cells" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Frontier Presentation: Anil Bagri (Genentec, San Francisco)
"The role of Neuropilin-2 in tumor lymphangiogenesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | MOLECULAR CONTROL OF LYMPH TRANSPORT ACTIVITY |
| Discussion Leader: David Bates (University of Bristol) |
7:30 pm - 7:55 pm | Melody Swartz (Swiss Federal Institute of Technology, EPFL)
"Functional-adaptive responses in lymphatic endothelium" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | David Zawieja (Texas A&M University Health Science Center)
"The regulation of the real lymphatic function - lymph transport" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Waldemar Olszewski (Polish Academy of Sciences, Warshaw)
"Hydraulic conductivity of human skin and subcutaneous tissue in normal and lymphedematous lower limbs" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Frontier Presentation: Carla Danussi (National Cancer Institute, CRO-IRCCS, Aviano, Italy)
"Emilin1 deficiency causes structural and functional defects of lymphatic vasculature" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GENETICS AND TREATMENT OF LYMPHATIC DISORDERS |
| Discussion Leader: David Zawieja (Texas A&M University Health Science Center) |
9:00 am - 9:20 am | David Bates (University of Bristol)
"Lymphatic targeting as a metastatic mechanism" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Miikka Vikkula (Universite Catholique de Louvain, Brussels)
"Etiology of lymph/vascular anomalies" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Eva M. Sevick-Muraca (Baylor College of Medicine, Houston)
"Human lymph imaging" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Tuomas Tammela (University of Helsinki)
"Reconstitution of collecting lymphatic vessels and sentinel lymph nodes with growth factor therapy" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Young Kwon Hong (University of Southern California, Los Angeles)
"Molecular basis of nuchal edema in Down Syndrome fetus" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | George A. Diaz (Mount Sinai School of Medicine, New York)
"Genetic studies of an autosomal recessive lymphedema-choanal atresia syndrome" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | THERAPEUTIC CHALLENGES IN LYMPHATIC DYSORDERS |
| Discussion Leader: Michael Detmar (Swiss Federal Institute of Technology, Zurich) |
7:30 pm - 8:00 pm | Jonathan Steven Alexander (LSU Health Sciences Center, Shreveport)
"Lymphangiogenesis in Experimental Inflammatory Bowel Disease" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Bronek Pytowski (ImClone Systems, New York)
"Therapeutic inhibition of tumor lymphangiogenesis: the promise and many vexing problems" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Stanley Rockson (Stanford University)
"Treatment of Lymphatic Dysfunction: State of the Art" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |