SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | MOLECULAR MECHANISMS IN LYMPHANGIOGENESIS |
| Discussion Leader: Guillermo Oliver (St. Jude Children's Res. Hospital, Memphis, TN) |
7:40 pm - 8:10 pm | Kari Alitalo (University of Helsinki, Finland) "Molecular mediators of lymphangiogenesis" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Peter Carmeliet (University of Leuven, Leuven, Belgium) "Mechanisms of lymphatic development" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9.20 pm | Stefan Schulte-Merker (Hubrecht Institute, Utrecht, The Netherlands) "Ccbe1 in embryonic lymphangiogenesis and disease" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LYMPHATIC VESSEL MORPHOGENESIS AND MATURATION |
| Discussion Leader: Elisabetta Dejana (University of Milan, Milan) |
9:00 am - 9:20 am | Jayakrishna Ambati (University of Kentucky College of Medicine, Lexington, USA) "Soluble VEGFR-2 as a natural inhibitor of lymphatic growth" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Friedemann Kiefer (Max-Planck-Institute, Münster) "Syk+ leukocytes in developmental lymphangiogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:50 am | Mark Kahn (University of Pennsylvania, Philadelphia, USA) "Lymphatic - platelet interactions" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Taija Makinen (Cancer Research UK London Research Institute, London, UK) "Regulation of lymphatic vessel remodelling" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Tatiana Petrova (University of Lausanne, Switzerland) "Transcriptional programs for lymphatic vascular remodeling and maturation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Miguel Torres (Spanish National Cancer Research Center, Madrid, Spain) "Megakaryocytes/platelets function during embryonic lymphangiogenesis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Lijun Xia (Oklahoma Medical Research Foundation, USA) "Endothelial podoplanin is required for lymphatic endothelial cell identity" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session 1 |
5:30 pm - 7:30 pm | TRANSCRIPTIONAL REGULATION OF LYMPHANGIOGENESIS |
| Discussion Leader: Anne Eichmann (College de France, Paris, France) |
5:30 pm - 5:50 pm | Guillermo Oliver (St. Jude Children's Research Hospital, Memphis, USA) "Prox1, a master regulator of developmental and postnatal lymphangiogenesis" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Young-Kwon Hong (University of Southern California, Los Angeles, USA) "Regulation of lymphatic lineage-specific differentiation" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Peter Koopman (The University of Queensland, Brisbane, Australia) "Sox7 and Sox17 as modifiers of Sox18 function in lymphatic development" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Jan Kitajewski (Columbia University, New York, USA) "Notch signaling in lymphatic differentiation" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SIGNAL TRANSDUCTION IN LYMPHATIC ENDOTHELIUM |
| Discussion Leader: Laura Benjamin (ImClone Systems, New York, USA) |
9:00 am - 9:20 am | Elisabetta Dejana (University of Milan, Milan, Italy) "Wnt signaling in vascular development and endothelial specification" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Masataka Majima (Kitasato University School of Medicine, Sagamihara, Japan) "Role of prostaglandins in enhancement of lymphangiogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Hellmut Augustin (German Cancer Research Center, Heidelberg, Germany) "Molecular pathways mediating lymphatic function" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Anne Eichmann (College de France, Paris, France) "Guidance cues in vascular development" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Hirotake Ichise (University of Tokyo) "Role of Ras in lymphangiogenesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Tetsuro Watabe (University of Tokyo, Tokyo, Japan) "Roles of transcriptional networks during formation of lymphatic vessels"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Philip D. King (University of Michigan Medical School, Ann Arbor, USA) "Induced systemic deletion of the RASA1 Ras GTPase-activating protein from adult mice results in extensive lymphatic vessel hyperplasia and death by chylothorax" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session 2 |
5:30 pm - 7:30 pm | LYMPHATIC ANATOMY AND TRANSPORT |
| Discussion Leader: Gou Young Koh (KAIST, Daejeon, Korea) |
5:30 pm - 5:50 pm | Donald McDonald (University of California, San Francisco, USA) "Plasticity of button-like junctions in initial lymphatics" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Melody Swartz (Swiss Federal Institute of Technology Lausanne, Switzerland) "Lymphatic transport in immunity and tolerance" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Anatoliy A Gashev (Texas A&M Health Science Center, Temple, USA) "Modulation of lymphatic transport in aging" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Short Talk: Shan Liao (Massachusetts General Hospital, Boston, USA) "Nitric oxide synthases (NOSs) regulate contraction of collecting lymphatic vessels in mice" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Short Talk: Sophie Lutter (Cancer Research UK, London, UK) "The role of smooth muscle cells in postnatal remodelling of lymphatic vasculature" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LYMPHATIC VASCULATURE IN IMMUNITY AND INFLAMMATION |
| Discussion Leader: Melody Swartz (Swiss Federal Institute of Technology Lausanne) |
9:00 am - 9:20 am | Gou Young Koh (Biomedical Center, Daejeon, Korea) "Role of macrophages and T-lymphocytes in inflammatory lymphangiogenesis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Gwendalyn Randolph (Mount Sinai School of Medicine, New York, USA) "Interactions between antigen-presenting cells and lymphatic collecting vessels" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Michael Sixt (Max Planck Institute of Biochemistry, Martinsried, Germany) "Mechanisms of dendritic cell entry into afferent lymphatics" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | David Jackson (MRC Human Immunology Unit, Oxford, UK) "Trafficking through lymphatic vessels in inflammation" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Peter Baluk (University of California, San Francisco, USA) "Inflammatory lymphangiogenesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Victor Engelhardt (University of Virginia Medical School, Charlottesville, USA) "Lymphatic endothelial cells mediate immunological tolerance to peripheral tissue antigens" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Todd Wuest (University of Oklahoma Health Science Center, USA) "Uncontrolled HSV-1 infection leads to selective destruction of lymphatic but not blood capillaries and blockade of soluble antigen transport" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session 3 |
5:30 pm - 7:30 pm | LYMPHATIC IMAGING |
| Discussion Leader: Kari Alitalo (University of Helsinki, Finland) |
5:30 pm - 5:50 pm | Rakesh Jain (Harvard Medical School, Boston, USA) "Imaging lymphatic structure and function in health and disease" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Nancy Ruddle (Yale University School of Medicine, New Haven, USA) "Imaging high endothelial venules and lymphatic vessels in living mice" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Eva Sevick-Muraca (Baylor College of Medicine, Houston, USA) "Lymphatic imaging of disease in humans" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Short Talk: Sagrario Ortega (Spanish National Cancer Research Center, Madrid, Spain) "A reporter mouse model to study the lymphatic system and lymphangiogenesis in vivo" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Short Talk: Viviane Mumprecht (Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland) "In vivo imaging of tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PATHOLOGICAL LYMPHANGIOGENESIS |
| Discussion Leader: David Jackson (MRC Human Immunology Unit, Oxford, UK) |
9:00 am - 9:20 am | Satoshi Hirakawa (Ehime University, Matsuyama, Japan) "Lymphatic invasion and cancer metastasis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Joel Moss (National Institutes of Health, Bethesda, USA) "Lymphatic involvement in idiopathic pulmonary fibrosis and lymphangioleiomyomatosis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Claus Cursiefen (University of Erlangen, Germany) "Ocular lymphangiogenesis and transplant rejection" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Short Talk: Lu Chen (University of California at Berkeley, USA) "A Novel Strategy to Promote High-Risk Corneal Transplant Survival" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Short Talk: Jonathan Sleeman (University of Heidelberg, Germany) "Regional and systemic effects of pro-lymphangiogenic factors produced by tumors" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Jens Titze (Friedrich Alexander University Erlangen-Nuremberg, Germany) "Role of macrophages and VEGF-C in blood pressure regulation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Mika Sawane (Shiseido Research Center, Yokohama, Japan) "Apelin regulates accumulation of subcutaneous adipose tissue by targeting lymphatic vessels"
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12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Andrzej Szuba (Wroclaw Medical University, Poland & Wroclaw Provincial Specialist Hospital, Research and Developement Center, Poland) "Macrophages, adventitial lymphatics and atherosclerosis - evidence from human studies" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session 4 |
5:30 pm - 7:30 pm | THERAPEUTIC TARGETING OF THE LYMPHATIC VASCULATURE |
| Discussion Leader: Donald McDonald (University of California, San Francisco, USA) |
5:30 pm - 5:50 pm | Anil Bagri (Genentech, South San Francisco, CA, USA) "Targeting lymphangiogenesis via neuropilin-2" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Laura Benjamin (ImClone Systems, New York, USA) "Molecular targets in the lymphatic vasculature" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Stanley Rockson (Stanford University, Stanford, USA) "Translational and clinical aspects of lymphatic disease" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Tuomas Tammela (University of Helsinki, Finland) "Therapeutic targeting of the lymphatic system" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |