SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | DEVELOPMENTAL (LYMPH)ANGIOGENESIS |
| Discussion Leader: Guillermo Oliver (St. Jude Children's Res. Hospital, Memphis, TN) |
7:40 pm - 8:00 pm | Rong Wang (University California San Francisco, USA)
"Molecular programing of mammalian arterial venous specification" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Stephan Schulte-Merker (Hubrecht Institute, Utrecht, The Netherlands)
"Lymphangiogenesis in fish and mice: comparing genes, comparing processes" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Mark Kahn (University of Pennsylvania, Philadelphia, USA)
"Signaling pathways in lymphatic development"
|
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Short Talk: Johnathan Astin (The University of Auckland, New Zeland)
"lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic development in zebrafish"
|
9:20 pm - 9:25 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MOLECULAR REGULATORS OF LYMPHANGIOGENESIS |
| Discussion Leader: Kathleen Caron (The University of North Carolina at Chapel Hill, USA) |
9:00 am - 9:20 am | Peter Carmeliet (Vesalius Research Center, Leuven, Belgium)
"Metabolism and vessel growth"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Natasha Harvey (Center for Cancer Biology, Adelaide, Australia)
"Defining signals that control morphogenesis of the lymphatic vasculature in the mouse embryo"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Holger Gerhardt (London Research Institute, UK)
"Pattern formation in (blood)-vascular networks" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Satish Srinivasan (St. Jude Children's Research Hospital, Memphis, USA)
"Molecular mechanisms of lymphatic valve development" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Tatiana Petrova (University of Lausanne, Switzerland)
"Transcriptional regulation of lymphatic valve morphogenesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Taija Makinen (Cancer Research Institute, UK)
"Planar cell polarity signaling regulates lymphatic valve development"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Young-Sup Yoon (Emory University, Atlanta, USA)
"Lymphatic neovascularization by lymphatic endothelial lineage cells differentiated from human pluripotent stem cells"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (Last names A to G inclusive) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MORPHOGENESIS OF THE LYMPHATIC VASCULAR NETWORK |
| Discussion Leader: Mark Kahn (University of Pennsylvania, Philadelphia, USA) |
7:30 pm - 7:50 pm | Eckhard Lammert (Institute of Metabolic Physiology, Dusseldorf, Germany)
"Mechanoinduction of lymph vessel expansion" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Walter Murfee (Tulane University, New Orleans, USA)
"Identifying lymphatic/blood endothelial cell dynamics during microvascular network growth" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Yulong He (Nanjing University, Nanjing, China)
"Molecular regulation of lymphatic network formation and remodeling in development" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Michael Detmar (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Molecular pathways mediating lymphatic vessel growth and development" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LYMPHATIC TRANSPORT AND FLOW |
| Discussion Leader: Melody Swartz (Swiss Federal Institute of Technology, Lausanne, Switzerland) |
9:00 am - 9:20 am | David Zawieja (Texas A&M Health Science Center, Temple, Texas, USA)
"Molecular mechanisms of the flow mediated regulation of lymph transport" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Virginia Huxley (University of Missouri, Columbia, USA)
"Natriuretic peptide modulation of lymphatic exchange: coupling of barrier and contractile function?"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Agnes Noel (University of Liege, Belgium)
"How do lymphatics deal with an interstitial environment?" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Short Talk: Risuke Mizuno (The University of Tokyo, Japan)
"High concentration of salt dysfunctions lymphatic activity through Na+-K+-ATPase-dependent mechanisms"
|
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Short Talk: Witold Kilarski (Swiss Federal Institute of Technology, Lausanne, Switzerland)
"A novel intravital imaging method of dermal lymphatic function reveals differential regulation of fluid vs. cell transport in acute inflammation"
|
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Kari Alitalo (University of Helsinki, Finland)
"VEGF-C/D/VEGFR-3: From structures to functional insights"
|
11:50 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (Last names H to M inclusive) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | LYMPHANGIOGENESIS IN CANCER |
| Discussion Leader: Michael Detmar (Swiss Federal Institute of Technology, Zurich, Switzerland) |
7:30 pm - 7:50 pm | Melody Swartz (Swiss Federal Institute of Technology, Lausanne, Switzerland)
"Lymphatic transport in regulating immunological tolerance"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Mihaela Skobe (Mount Sinai, New York, USA)
"Role of lymphatic endothelium in cancer metastasis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Dontscho Kerjaschki (University of Vienna, Austria)
"Initial steps of lymphatic metastasis" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Short Talk: Alanna Ruddell (Fred Hutchinson Cancer Research Center, USA)
"B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Lena Claesson-Welsh (Uppsala University, Uppsala, Sweden)
"VEGFR2 signaling in the regulation of vascular permeability" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LYMPHATIC REGULATION OF INFLAMMATION |
| Discussion Leader: David Jackson (University of Oxford, UK) |
9:00 am - 9:20 am | Alberto Mantovani (Istituto Clinico Humanitas, Milan, Italy)
"Selective expression and function of the chemokine decoy and scavenger receptor D6 in lymphatic endothelium" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:40 am | Short Talk: Steven Proulx (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Non-invasive longitudinal imaging of collecting lymphatic vessel function and metastatic spread of murine melanoma"
|
9:40 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Short Talk: Masataka Majima (Kitasato University, Japan)
"Prostanoids as regulators of pathological lymphangiogenesis"
|
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Sirpa Jalkanen (Institute for Molecular Medicine, Turku, Finland)
"Lymphocyte trafficking within lymphatics - shared mechanisms with cancer cells?" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Cornelia Halin-Winter (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Impact of inflammation on lymphatic vessel phenotype and function" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Short Talk: Veronique Angeli (National University of Singapore Korea)
"Neutrophils - unexpected key players in driving lymphangiogenesis and resolution of inflammation"
|
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Pierre-Yves von der Weid (University of Calgary, Alberta, Canada)
"Mesenteric lymphatic vessel dysfunction in intestinal inflammation-mechanism and importance for IBD pathogenesis" |
12:05 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | LYMPHATICS AND IMMUNITY |
| Discussion Leader: Alberto Mantovani (Istituto Clinico Humanitas, Milan, Italy) |
7:30 pm - 7:50 pm | Nancy Ruddle (Yale University School of Medicine, New Haven, USA)
"Visualizing the Immune Response" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Michael Carroll (Immune Disease Institute, Harvard, USA)
"B cell acquisition of antigen in draining lymph nodes" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Gou-Young Koh (Biomedical Center, Daejeon, Korea)
"Regulation of Lymphangiogenesis by Immune Cells" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Short Talk: Sophia Ran (Southern Illinois University, USA)
"Modeling macrophage transdifferentiation into lymphatic endothelial progenitors"
|
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Louise Johnson (University of Oxford, UK)
"A novel role for the chemokine CX3CL1 (Fractalkine) in promoting DC trafficking through the lymphatics to the lymph node in inflammation"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | LYMPHATICS AND DISEASE |
| Discussion Leader: Peter Mortimer (St George's, University of London, UK) |
9:00 am - 9:20 am | Donald McDonald (University of California San Francisco, USA)
"Plasticity of lymphatics in health and disease" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Stanley Rockson (Stanford University, California, USA)
"Diagnosis and Treatment of Human Lymphedema: Translation from the Animal Model" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Eva-Sevick Muraca (The Brown Foundation, Texas, USA)
"Near-Infrared Fluorescence Lymphatic Imaging Discovery in Translation" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Steve Jeffery (St George's Hospital Medical School, London, England)
"Phenotyping and gene identification in human primary lymphoedema" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Jayakrishna Ambati (University of Kentucky College of Medicine, Lexington, USA)
"The function of soluble VEGFR-2 in the retina" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Fusa Ogata (The University of Tokyo, Japan)
"Smooth muscle phenotypic modulation plays an important role in lymphatic vessel remodeling in lymphedema"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Sidney Levy (Peter Maccallum Cancer Center, Australia)
"New models of secondary lymphoedema, a common complication of cancer surgery"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III (Last names N to Z) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW DIRECTIONS: LYMPHATICS AND METABOLISM |
| Discussion Leader: Donald McDonald (University of California San Francisco, USA) |
7:30 pm - 7:50 pm | Gwendalyn Randolph (Washington University School of Medicine, St. Louis, USA)
"Lymphatic vessel and immune cell interactions regulate adipocyte phenotype" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Short Talk: Catherine Martel (Washington University in St. Louis, MO, USA)
"Reverse cholesterol transport relies on a functional lymphatic network"
|
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Chris Porter (Monash Institute of Pharmaceutical Sciences, Victoria, Australia)
"Exploring the interface between lipid and drug transport in the intestinal lymphatics" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Short Talk: Eser Tolunay (National Institutes of Health, Bethesda, USA)
"NIH update on lymphatic research"
|
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:30 pm | General discussion of future directions in lymphatic research |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |