Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Organelle Crosstalk |
| Discussion Leaders: Frederick Hughson (Princeton University, USA) and Anne Spang (University of Basel, Switzerland) |
7:40 pm - 8:20 pm | Pietro De Camilli (Yale University, USA) "Lipid Signaling in the Control of Membrane Dynamics and Interactions" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Jennifer Lippincott-Schwartz (National Institutes of Health, USA) "Trafficking of Fatty Acids Between Lipid Droplets and Mitochondria" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Organelle Identity and Dynamics |
| Discussion Leader: Scott Emr (Cornell University, USA) |
9:00 am - 9:20 am | Alice Ting (Massachusetts Institute of Technology, USA) "Spatially-Resolved Proteomic Mapping of Organellar Membranes in Living Cells" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:40 am | Frederic Bard (Institute of Molecular and Cell Biology, Singapore) "Journey to the Center of the Cell" |
9:40 am - 9:45 am | Discussion |
9:45 am - 10:05 am | Daniel Kahne (Harvard University, USA) "Studies on the Assembly of the Outer Membrane in E. coli" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Akihiko Nakano (University of Tokyo, Japan) "Super-Resolution Live Imaging Approach to Understanding ER-Golgi and Intra-Golgi Cargo Transport" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Chris Fromme (Cornell University, USA) "Extensive
GTPase Crosstalk Regulates Trafficking at the Golgi" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Deborah Fass (Weizmann Institute, Israel) "Organelle Responses to Blocking Disulfide Bonding in the Extracellular Matrix" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Esben Lorentzen (Max Planck Institute of Biochemistry, Germany) "Targeting Complexes for Ciliary Membrane Proteins" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Translocation and Membrane Assembly |
| Discussion Leader: Tom Rapoport (Harvard Medical School / Howard Hughes Medical Institute, USA) |
7:30 pm - 7:50 pm | Elke Deuerling (University of Konstanz, Germany) "The Principle of Antagonism Ensures ER Targeting Specificity" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Shu-Ou Shan (California Institute of Technology, USA) "Searching for the Membrane During Co-Translational Protein Targeting" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Jonathan Weissman (Howard Hughes Medical Institute / University of California, San Francisco, USA) "Molecular Insights into Co-Translational Translocation Revealed by Proximity-Specific Ribosome Profiling" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Tslil Ast (The Weizmann Institute of Science, Israel) "Finding the Plunger – Unclogging SRP Independent Translocons" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Robert Keenan (University of Chicago, USA) "Tail-Anchored Membrane Protein Recognition by Get3" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Membrane Dynamics: Shaping and Fission |
| Discussion Leader: Charlie Barlowe (Dartmouth Medical School, USA) |
9:00 am - 9:20 am | John Briggs (European Molecular Biology Laboratory, Germany) "Using Modern Electron Microscopy Approaches to Study the Mechanisms of Coated Vesicle Assembly" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sandra Schmid (University of Texas Southwestern Medical Center, USA) "Regulation of Clathrin Mediated Endocytosis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Margaret Robinson (University of Cambridge, United Kingdom) "Adaptors for Coated Vesicles" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Adam Frost (University of California, San Francisco, USA) "Atomic Resolution CryoEM Reveals New Concepts in Membrane Remodeling" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Britta Qualmann (Jena University Hospital / Friedrich Schiller University Jena, Germany) "Shaping Membranes – Roles in Vesicle Formation and Membrane Organization" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Aurelien Roux (University of Geneva, Switzerland) "A Randomly Triggered, but Concerted, GTP Hydrolysis by Dynamin Explains the Stochastic Time Distribution of Fission In Vivo" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Gunther Hollopeter (Stowers Institute for Medical Research / Howard Hughes Medical Institute, USA) "FCHo/SGIP Proteins Are Allosteric Activators of the AP2 Clathrin Adaptor Complex" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Membrane Dynamics: Fusion and Its Regulation |
| Discussion Leader: Suzanne Pfeffer (Stanford School of Medicine, USA) |
7:30 pm - 7:50 pm | Francis Barr (University of Oxford, United Kingdom) "Structure-Function Analysis of Rab GEFs" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | James Rothman (Yale University, USA) "Regulation of Membrane Fusion" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Alexey Merz (University of Washington, USA) "Why SM Proteins Are Needed for Membrane Fusion In Vivo" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Michael Zick (Geisel School of Medicine at Dartmouth, USA) "Reconstituting Membrane Fusion – Setting the Stage for Multiple Actors" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Junjie Hu (Institute of Biophysics, China) "Molecular Basis for Sey1p-Mediated Homotypic ER Fusion" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lipids in Signaling and Disease |
| Discussion Leader: Sean Munro (MRC Laboratory of Molecular Biology, United Kingdom) |
9:00 am - 9:20 am | Nihal Altan-Bonnet (National Institutes of Health, USA) "Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Xiaochen Wang (National Institute of Biological Sciences, China) "Coordinated Actions of Phosphoinositides Regulate Phagocytosis of Apoptotic Cells in C. elegans" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Lois Weisman (University of Michigan, USA) "A New, Unexpected Role for the Yeast Vacuole/Lysosome" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Itay Budin (University of California, Berkeley, USA) "Lipid Engineering Approaches Reveal Cellular Roles for Membrane Viscosity" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Christopher Burd (Yale School of Medicine, USA) "Insights into Lipid and Protein Sorting in the Golgi Apparatus Using a New Sphingomyelin Probe" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Bruno Antonny (Centre National de la Recherche Scientifique, France) "From Zero to Six Double Bonds: Phospholipid Unsaturation and Organelle Functions" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Tobias Walther (Harvard T.H. Chan School of Public Health, USA) "Lipid Droplet Cell Biology and Physiology" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Quality Control of Membrane Proteins |
| Discussion Leader: Gia Voeltz (University of Colorado, USA) |
7:30 pm - 7:50 pm | Pedro Carvalho (Center for Genomic Regulation, Spain) "Protein Quality Control at the Inner Nuclear Membrane" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Russell Debose-Boyd (University of Texas Southwestern Medical Center, USA) "Sterol-Accelerated Degradation of HMG CoA Reductase from ER Membranes" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Ramanujan Hegde (MRC Laboratory of Molecular Biology, United Kingdom) "Quality Control of Membrane Proteins" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Ryan Baldridge (Harvard Medical School, USA) "Exploring the Mechanism of ERAD Using a Reconstituted System" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Carolyn Sevier (Cornell University, USA) "Sil1 as a Thiol-Based Redox Regulator of the Molecular Chaperone BiP" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Metabolism and Autophagy |
| Discussion Leader: Maya Schuldiner (Weizmann Institute of Science, Israel) |
9:00 am - 9:20 am | Vladimir Denic (Harvard University, USA) "Activation of Atg1 Kinase by Receptor-Bound Targets Initiates Selective Autophagy" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Aimee Edinger (University of California, Irvine, USA) "Starving Cancer Cells to Death with Sphingolipids" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Tamotsu Yoshimori (Osaka University, Japan) "Insights into Membrane Dynamics in Autophagy" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Robbie Loewith (University of Geneva, Switzerland) "TORC2 and Plasma Membrane Homeostasis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Roberto Zoncu (University of California, Berkeley, USA) "Molecular Mechanisms of Nutrient Sensing by the Lysosome" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Ann Wehman (University of Wuerzburg, Germany) "Trafficking of the Midbody After Cell Division" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Ming Li (Weill Institute, Cornell University, USA) "Trafficking and Turnover of Lysosomal Membrane Proteins" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Frontiers in Molecular Membrane Biology |
| Discussion Leader: Benjamin Glick (University of Chicago, USA) |
7:30 pm - 7:50 pm | Simon Scheuring (U1006 Inserm / Aix-Marseille Université, France) "High-Speed Atomic Force Microscopy: Watching Dynamic Processes at the Membrane at High Spatio-Temporal Resolution" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Randy Schekman (University of California, Berkeley, USA) "Sorting
of MicroRNAs for Secretion in Exosomes" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Fabienne Paumet (Thomas Jefferson University, USA) "Reorganization of Host Vesicle Trafficking by Chlamydia" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Jingshi Shen (University of Colorado at Boulder, USA) "Genome-Wide Genetic Dissection of Mammalian Regulated Exocytosis – Novel Components and Molecular Mechanisms" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | William Shih (Dana-Farber Cancer Institute, USA) "Templating Lipid Bilayers with DNA-Origami Scaffolds" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |