Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Communication Between Organelles and with the Outside
Discussion Leader: Anne Spang (Biozentrum, University of Basel, Switzerland)
7:40 pm - 8:20 pm
Jodi Nunnari (University of California, Davis, USA)
"Emerging Network of Membrane Contact Sites"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Randy Schekman (University of California, Berkeley, USA)
"RNA Sorting and Secretion in Exosomes"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Biosynthesis and the Early Secretory Pathway
Discussion Leader: Akihiko Nakano (RIKEN Center for Advanced Photonics, Japan)
9:00 am - 9:20 am
Jochen Zimmer (University of Virginia School of Medicine, USA)
"ABC Transporters Implicated in Biopolymer Translocation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tom Rapoport (Harvard Medical School / Howard Hughes Medical Institute, USA)
"Mechanism of ER-Associated Protein Degradation (ERAD)"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Junjie Hu (Institute of Biophysics, Chinese Academy of Sciences, China)
"Stress Sensing and Apoptotic Induction by Tubular ER Protein HT008"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Qian Feng-Jurgeit (ETH Zurich, Switzerland)
"Mechanical Force Induces Mitochondrial Fission via the Canonical Fission Machinery"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ulrike Kutay (Institute of Biochemistry, ETH Zurich, Switzerland)
"Targeting of Membrane Proteins from the ER to the Inner Nuclear Membrane"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Catherine Rabouille (Hubrecht Institute, The Netherlands)
"Sec16: A Stress Response Protein"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Franck Perez (Institut Curie, CNRS, France)
"Exploring and Exploiting Intracellular Transport of Mammalian Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Maya Schuldiner (Weizmann Institute of Science, Israel)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Golgi Function and Transport
Discussion Leader: Jennifer Lippincott-Schwartz (Howard Hughes Medical Institute, USA)
7:30 pm - 7:50 pm
Frederick Hughson (Princeton University, USA)
"Know When to Hold 'Em, Know When to Fold 'Em: Chaperoning SNARE Assembly to Control Membrane Fusion"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Benjamin Glick (University of Chicago, USA)
"Kinetic Mapping of Secretory and Endocytic Traffic in Yeast"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Kazuo Kurokawa (RIKEN Center for Advanced Photonics, Japan)
"4D Imaging of Cargo Delivery in Maturating Golgi Cisternae in S. cerevisiae "
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
John Shin (MRC Laboratory of Molecular Biology, United Kingdom)
"Golgins and Tethering of Vesicles at the Golgi Apparatus"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Robert Fuller (University of Michigan Medical School, USA)
"Molecular Function and Structural Features of Vps13 "
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Regulation of Exo- and Endocytosis
Discussion Leader: Charlie Barlowe (Geisel School of Medicine, Dartmouth College, USA)
9:00 am - 9:20 am
Axel Brunger (Stanford University, USA)
"Molecular Mechanisms of Synaptic Vesicle Priming"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ian Macara (Vanderbilt University Medical Center, USA)
"Regulation of Exocyst by Polarity Proteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Elizabeth Chen (University of Texas Southwestern Medical Center, USA)
"Spectrin, a Dynamic Mechanosensory Protein that Promotes Cell Membrane Fusion"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Michael Ailion (University of Washington, USA)
"Membrane Trafficking Proteins Important for Dense-Core-Vesicle Maturation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Christian Ungermann (University of Osnabrueck, Germany)
"Reconstitution of Endosomal Rab Delivery and Activation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Rosa Puertollano-Moro (National Institutes of Health, USA)
"Emerging New Roles of Lysosomes in Cellular Homeostasis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Fernando Martin-Belmonte (Spanish National Research Council (CSIC), Spain)
"Epithelial-Stromal Crosstalk in Tube Development"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Communication in Disease,
Infection and Immune Response
Discussion Leader: Chris Fromme (Weill Institute for Cell and Molecular Biology, USA)
7:30 pm - 7:50 pm
Thijn Brummelkamp (Netherlands Cancer Institute, The Netherlands)
"Haploid Genetic Screens to Study Pathogen Entry"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Gillian Griffiths (Cambridge Institute for Medical Research, University of Cambridge, United Kingdom)
"Fine-Tuning Lysosomal Secretion"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Paul Lehner (University of Cambridge, United Kingdom)
"Forward Genetic Screens to Identify Novel Ubiquitin E3 Ligases in the Secretory Pathway"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Fabienne Paumet (Thomas Jefferson University, USA)
"Chlamydia Hijacks ARF GTPases to Coordinate Microtubule Post-Translational Modifications and Golgi Positioning"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Stefania Spano (University of Aberdeen, United Kingdom)
"A Rab32 Trafficking Pathway that Prevents Bacterial Infections"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alternative Ways of
Communication
Discussion Leader: Liz Miller (MRC Laboratory of Molecular Biology, United Kingdom)
9:00 am - 9:20 am
Robert Farese (Harvard T.H. Chan School of Public Health, USA)
"Mechanisms of Lipid Homeostasis in the Endoplasmic Reticulum"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Michal Eisenberg-Bord (Weizmann Institute of Science, Israel)
"Molecular Determinants of a Lipid Droplet Subpopulation at the Nucleus-Vacuole Junction"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Mitsuo Tagaya (Tokyo University of Pharmacy and Life Sciences, Japan)
"Versatile Functions of Syntaxin 17 in the ER-Mitochondria Contact Site"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Adam Hughes (University of Utah, USA)
"Nutrient-Regulated Destruction of Mitochondrial Metabolite Carriers by the MDC Pathway"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Clotilde Thery (INSERM U932, Institut Curie, France)
"Molecular Mechanisms of Biogenesis and Secretion of Exosomes and Other Extracellular Vesicles"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Chiara Zurzolo (Pasteur Institute, France)
"Differential Identity of Tunneling Nanotube and Filopodia and Revealed by the Opposite Functions of Actin Regulatory Complexes and Ultrastructural Analysis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Katharina Gaus (University of New South Wales, Australia)
"T Cell Receptor Clustering – A Mechanism of Signal Transduction"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Regulation of Transport by Lipids
Discussion Leader: Julie Brill (The Hospital for Sick Children, Canada)
7:30 pm - 7:50 pm
Tamas Balla (National Institute of Child Health and Human Development, NIH, USA)
"Phosphatidylinositol 4-Phosphate Gradients Shape the Lipid Landscape of Eukaryotic Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Elina Ikonen (University of Helsinki, Finland)
"Lipid Trafficking and Storage in the ER"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Suzanne Pfeffer (Stanford University School of Medicine, USA)
"Cholesterol Regulation of Lysosomes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Julia Von Blume (Max Planck Institute of Biochemistry, Germany)
"Cargo Sorting During Protein Secretion"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Christopher Burd (Yale School of Medicine, USA)
"Sphingomyelin-Dependent Sorting and Trafficking in the Secretory Pathway"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Degradation
Pathways and Signalling
Discussion Leader: Maya Schuldiner (Weizmann Institute of Science, Israel)
9:00 am - 9:20 am
Scott Emr (Weill Institute for Cell and Molecular Biology, Cornell University, USA)
"ESCRTs and Ubiquitin Function in Lysosomal Membrane Protein Turnover and Quality Control"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lois Weisman (University of Michigan, USA)
"Dynamic Regulation of the Endosomal Lipid PI(3,5)P2"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Sharon Tooze (The Francis Crick Institute, United Kingdom)
"Trafficking to the Forming Autophagosome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Michael Skowyra (Washington University School of Medicine, USA)
"Triggered Recruitment of ESCRT Machinery Facilitates Endolysosomal Membrane Repair"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Yanzhuang Wang (University of Michigan, USA)
"GRASP55 Senses Energy Deprivation Through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Beth Levine (University of Texas Southwestern Medical Center, USA)
"Crucial Role of an Inner Mitochondrial Membrane Receptor in Mitophagy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Nektarios Tavernarakis (IMBB, Foundation for Research and Technology - Hellas (FORTH), Greece)
"Regulation and Roles of Autophagy in the Mammalian Brain"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New
Frontiers in Molecular Membrane Biology
Discussion Leader: Ramanujan Hegde (MRC Laboratory of Molecular Biology, United Kingdom)
7:30 pm - 7:50 pm
Heidi McBride (McGill University, Canada)
"Mitochondrial Vesicles in Antigen Presentation: A New Paradigm for Parkinson's Disease?"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Laura Lackner (Northwestern University, USA)
"Mitochondrial-Driven Assembly of a Cortical Anchor for Mitochondria and Dynein"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Manuel Leonetti (Chan Zuckerberg Biohub, USA)
"'GFP-Omics': Endogenous GFP-Tagging of the Human Proteome"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Michael Bassik (Stanford University, USA)
"Systematic Exploration of Endocytosis and Phagocytosis Pathways Using Genome-Wide CRISPR/Cas9 Screens and Genetic Interaction Maps"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Tomas Kirchhausen (Harvard Medical School, USA)
"Cellular Imaging from Molecules to Organisms"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure