Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Biology of the Endoplasmic Reticulum
Discussion Leader: Francis Barr (University of Oxford, United Kingdom)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
Tom Rapoport (Harvard Medical School / Howard Hughes Medical Institute, USA)
"Mechanism of ER-Associated Protein Degradation (ERAD)"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Gia Voeltz (Howard Hughes Medical Institute / University of Colorado Boulder, USA)
"ER-Mitochondria Contact Sites Are Platforms for Morphological Decision Making"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organelle Interactions and Communication
Discussion Leader: Catherine Rabouille (Hubrecht Institute, The Netherlands)
9:00 am - 9:20 am
Mike Henne (University of Texas Southwestern Medical Center, USA)
"Spatial Organization of Lipid Droplets at Organelle Contacts in Yeast and Metazoans"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Ayelen Gonzalez Montoro (University of Osnabrueck, Germany)
"Function of the Vacuole Mitochondria Contact Site (vCLAMP) Organelle Contact Site"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Jeeyun Chung (Harvard University, USA)
"Lipid Droplet Assembly Factor-1 and Seipin Form a Lipid Droplet Assembly Complex"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jodi Nunnari (University of California, Davis, USA)
"Mitochondrial Behavior"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Maya Schuldiner (Weizmann Institute of Science, Israel)
"New Routes for Targeting Proteins to Organelles"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Martin Graef (Max Planck Institute for Biology of Aging, Germany)
"Fatty Acid Channeling Drives Autophagic Membrane Formation at Phagophore-ER Contacts During Autophagy"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Fubito Nakatsu (Niigata University School of Medicine, Japan)
"Countertransport of Lipids at Membrane Contact Sites and Its Role in Membrane Trafficking"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Karin Reinisch (Yale University School of Medicine, USA)
"The Function of VPS13 and Chorein-N Motif Proteins in Lipid Transfer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Shaping, Fusing and Dividing Membranes
Discussion Leader: Frederick Hughson (Princeton University, USA)
7:30 pm - 7:50 pm
Phyllis Hanson (University of Michigan Medical School, USA)
"ESCRT Function in Membrane Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sandra Schmid (University of Texas Southwestern Medical Center, USA)
"Phenotypic Classification of Early Acting EAPs Using a Novel Disassembly Asymmetry Score Analysis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Wesley Sundquist (University of Utah, USA)
"The ESCRT Pathway in Cytokinetic Abscission and the Abscission Checkpoint"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
William Wickner (Geisel School of Medicine, Dartmouth College, USA)
"Tethering Controls the Functionality of Trans-SNARE Pairing"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biosynthesis and Quality Control at Membranes
Discussion Leader: Randy Schekman (University of California, Berkeley, USA)
9:00 am - 9:20 am
Scott Emr (Weill Institute for Cell and Molecular Biology, Cornell University, USA)
"Membrane Protein Quality Control: Writing and Reading the Ubiquitin Code in ESCRT-Mediated Protein Turnover"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Suzanne Hoppins (University of Washington, USA)
"Phosphorylation of Mitofusin GTPase Domain Regulates Fusion Activity"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Robert Keenan (University of Chicago, USA)
"A Novel Translocon for Biogenesis of Multi-Pass Membrane Proteins"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Liz Miller (MRC Laboratory of Molecular Biology, United Kingdom)
"Co-Translational Quality Control of Membrane Protein Biogenesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Friedrich Foerster (Utrecht University, The Netherlands)
"Protein Biogenesis at the ER Studied In Situ "
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Simon Newstead (University of Oxford, United Kingdom)
"Structural Basis for pH-Dependent Retrieval of ER Proteins from the Golgi Apparatus by the KDEL Receptor"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Lan Wang (University of California, San Francisco, USA)
"Structure of the AAA Protein Msp1 Elucidates Its Mechanism of Extracting Mislocalized Membrane Proteins"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Julia Von Blume (Yale School of Medicine, USA)
"Mechanism of Ca2+ and Sphingomyelin Dependent Protein Secretion"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipid Homeostasis and Regulation
Discussion Leader: Lois Weisman (University of Michigan, USA)
7:30 pm - 7:50 pm
Jeremy Baskin (Cornell University, USA)
"Emerging Roles for Phosphoinositide-Binding Proteins in Cell Signaling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Wanda Kukulski (MRC Laboratory of Molecular Biology, United Kingdom)
"Linking Membrane Architecture and Function by Correlative Microscopy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ilya Levental (University of Texas Health Science Center at Houston, USA)
"The Structural Determinants and Functional Consequences of Transmembrane Protein Affinity for Ordered Membrane Domains"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Adrian Salic (Harvard Medical School, USA)
"Lipid-Dependent Signaling at the Ciliary Membrane"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Specialization in Cells
Discussion Leader: Phyllis Hanson (University of Michigan Medical School, USA)
9:00 am - 9:20 am
Juan Bonifacino (National Institute of Child Health and Human Development, NIH, USA)
"Mechanisms of Vesicle Tethering at the TGN"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Lauren Jackson (Vanderbilt University, USA)
"Mammalian Retromer Is an Adaptable Plastic Scaffold for Cargo Sorting from Endosomes"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Markus Babst (University of Utah, USA)
"Plasma Membrane Tension Regulates Eisosome Structure and Function"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Maxence Nachury (University of California, San Francisco, USA)
"Quality Control of the Primary Cilia Proteome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Melissa Rolls (Pennsylvania State University, USA)
"Wnt Signaling Proteins at Dendrite Branch Points Control Neuronal Microtubule Organization"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Thomas Pucadyil (Indian Institute of Science Education and Research, India)
"ATP-Dependent Membrane Remodeling Links EHD1 Functions to Endocytic Recycling"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Suzanne Pfeffer (Stanford University School of Medicine, USA)
"Rab GTPase Phosphorylation Blocks Ciliary Hedgehog Signaling in the Brain"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Roberto Zoncu (University of California, Berkeley, USA)
"Regulation of Lysosomal mTORC1 Signaling by Inter-Organelle Contacts"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Maintenance of Organelle Identity
Discussion Leader: Benjamin Glick (University of Chicago, USA)
7:30 pm - 7:50 pm
Elizabeth Conibear (University of British Columbia, Canada)
"Targeting Proteins to Membrane Contact Sites"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Priya Gurumoorthy (Max Planck Institute of Biophysical Chemistry, Germany)
"SNARE Mimicking Factors: A Threat to Membrane Fusion"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Chris Fromme (Cornell University, USA)
"Regulation of GTPases at the Golgi Complex"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Mary Munson (University of Massachusetts Medical School, USA)
"Activation of the Exocyst Tethering Complex for SNARE Complex Regulation and Membrane Fusion"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Anne Spang (Biozentrum, University of Basel, Switzerland)
"Compartmentalisation in the Endosomal System"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Pathogen Manipulation of Host Membranes
Discussion Leader: Suzanne Pfeffer (Stanford University School of Medicine, USA)
9:00 am - 9:20 am
Nihal Altan-Bonnet (National Institutes of Health, USA)
"Viral Exploitation of Extracellular Vesicles for Transmission"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Orna Cohen-Fix (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Mixing of Parental Genomes After Fertilization in C. elegans Requires Pronuclear Membrane Fusion that Generates a Novel Membrane Structure"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Heike Folsch (Northwestern University, USA)
"AP-1B Facilitates Endocytosis During Cell Migration"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Peter Cullen (University of Bristol, United Kingdom)
"Structural Basis for Selective Endosomal Sorting by BAR Domain-Containing Sorting Nexins"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Shaeri Mukherjee (University of California, San Francisco, USA)
"Lessons Learned from Intracellular Bacteria: How to Remodel Rhe Host Cell"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Patrycja Kozik (MRC Laboratory of Molecular Biology, United Kingdom)
"Regulation of Endolysosomal Membrane Permeability in Dendritic Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
John Schoggins (The University of Texas Southwestern Medical Center, USA)
"CRISPR Screening Reveals an ER Resident Antiviral Protein that Suppresses Flavivirus Replication"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jonathan Weissman (University of California, San Francisco, USA)
"Global Approaches to Understanding Membrane Biology"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Visualizing Cells and Molecules in Context
Discussion Leader: Ramanujan Hegde (MRC Laboratory of Molecular Biology, United Kingdom)
7:30 pm - 7:50 pm
Ruben Fernandez-Busnadiego (Max Planck Institute of Biochemistry, Germany)
"Cryo-Electron Tomography: The Cell Biology that Came in from the Cold"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Anjon Audhya (University of Wisconsin-Madison, USA)
"Native ESCRT Dynamics as Revealed by Lattice Light Sheet Imaging of CRISPR/Cas9-Modified Human Cell Lines"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Srigokul Upadhyayula (University of California, Berkeley, USA)
"Rapid Protein-Specific Nanoscale Imaging of Neural Circuits Across Cortical Columns and Whole Brains"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Catherine Rabouille (Hubrecht Institute, The Netherlands)
"Sec Bodies Form in Response to Sodium Stress and Ire1 Activation, both Triggered by Nutrient Starvation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Jennifer Lippincott-Schwartz (Howard Hughes Medical Institute, USA)
"New Approaches for Imaging the Spatial and Temporal Dynamics of Organelles and Molecules Within Cells"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure