Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Biogenesis and Function of Membranes
Discussion Leader: Suzanne Pfeffer (Stanford University School of Medicine, United States)
7:40 pm - 7:50 pm
Tom Rapoport (Harvard Medical School / HHMI, United States)
"Translocation In and Out of Organelles"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:30 pm
Gillian Griffiths (University of Cambridge, United Kingdom)
"Control of Secretion at the Immunological Synapse"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Ramanujan Hegde (MRC Laboratory of Molecular Biology, United Kingdom)
"The Biogenesis of Multipass Membrane Proteins"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Connecting Membranes
Discussion Leaders: Lilach Sheiner (University of Glasgow, United Kingdom) and Jennifer Lippincott-Schwartz (Howard Hughes Medical Institute, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Robin Klemm (University of Oxford, United Kingdom)
"Mechanisms Driving Lipid Droplet Biogenesis during Adipocyte Differentiation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Ori Avinoam (Weizmann Institute of Science, Israel)
"Size Matters: Unveiling the Unique Exocytosis Mechanism of Large Vesicles in Exocrine Tissues"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Seung-Yeol Park (POSTECH, South Korea)
"Regulation of COPI Vesicle Fission by Short Lipids Transferred through ER-Golgi Membrane Contact"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Maria Bohnert (University of Münster, Germany)
"Tethering Fat: Lipid Droplet-Organelle Contact Sites"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
William Prinz (UT Southwestern, United States)
"Lipid Transport at Organelle Contact Sites"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Xiaohan Li (MRC Laboratory of Molecular Biology, United Kingdom)
"Intrinsically Disordered Regions in Sec24 Paralogs Tune COPII Vesicle Size and Occupancy"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
LIANG MA (UC Berkeley, HHMI, United States)
"Two RNA-Binding Proteins Mediate the Sorting of miR223 from Mitochondria into Exosomes"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Gia Voeltz (Howard Hughes Medical Institute / University of Colorado Boulder, United States)
"Function of ER Membrane Contact Sites"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Lois Weisman (University of Michigan, United States) and Mary Munson (University of Massachusetts Chan Medical School, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism and Signaling at Membranes
Discussion Leader: Scott Emr (Cornell University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Claudio De Virgilio (University of Fribourg, Switzerland)
"Metabolic Control of TORC1"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Rosa Puertollano Moro (National Institutes of Health, United States)
"Mechanisms of Cellular Response to Stress"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Monther Abu-Remaileh (Stanford University, United States)
"Metabolism Control at the Lysosome"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Ralf Erdmann (Ralf Erdmann, Head of Department, Ruhr-University Bochum, Germany)
"Biogenesis of Peroxisomes: From Yeast to Man"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ludger Johannes (Institut Curie, France)
"Growth Factor Induced Desialylation for the Fast Control of Endocytosis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Biogenesis and Quality Control at Membranes
Discussion Leaders: Liz Miller (MRC Laboratory of Molecular Biology, United Kingdom) and Rebecca Voorhees (California Institute of Technology, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
David Teis (Medical University of Innsbruck, Austria)
"The Defective for SREBP Cleavage (Dsc) Ubiqutin Ligase Complex Mediates Membrane Quality Control for Golgi and Endosomes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Prasanna Satpute-Krishnan (Uniformed Services University, United States)
"Competition for Calnexin Binding Regulates Secretion and Turnover of Misfolded GPI-Anchored Proteins"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Ron Kopito (Stanford University, United States)
"The Role of UFMylation in 60S Ribosomal Subunit Recycling"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Sonya Neal (University of California, San Diego, United States)
"An ERAD-Independent Role for Derlin Dfm1 in Regulating Sphingolipid Metabolism"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Agnieszka Chacinska (IMol Polish Academy of Sciences, Poland)
"How Mitochondria Control Cellular Protein Homeostasis"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Min Zhuang (ShanghaiTech University, China)
"Role of Ubiquitin Ligases in Peroxisome Homeostasis"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Ofir Klein (Weizmann Institute of Science, Israel)
"Mapping the ER-Mitochondria Contact Site Proteome Uncovers New Players in Mitochondrial Homeostasis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Johannes Herrmann (University of Kaiserslautern, Germany)
"Organized Aggregation of Mitochondrial Proteins as a Strategy to Protect Cellular Proteostasis"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipid Homeostasis at Membranes
Discussion Leader: Randy Schekman (University of California, Berkeley, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Joana Ferreira (University of Oxford, United Kingdom)
"The role of Pex30-containing complexes in linking the ER to multiple organelles"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Christopher Stefan (University College London, United Kingdom)
"Roles of ER-PM Cross Talk and the PI Kinase-TORC2 Signaling Nexus in Cell Integrity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Julia von Blume (Yale University, United States)
"Mechanism of Secretory Granule Biogenesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Abdou Rachid Thiam (Ecole Normale Supérieure, France)
"Triggering Neutral Lipid Condensation Within the ER Membrane"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Remodeling, Fission and Fusion
Discussion Leaders: Jodi Nunnari (University of California, Davis & Altos Labs, United States) and Haoxi Wu (MRC Laboratory of Molecular Biology, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Josep Rizo (UT Southwestern Medical Center, United States)
"Mechanisms Underlying the Exquisite Regulation of Neurotransmitter Release"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
William Wickner (Dartmouth College, United States)
"Reconstituted Vacuole Fusion; Updating the Membrane Fusion Paradigm"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Natasha Buwa (UMass Chan Medical School, United States)
"Exocyst Undergoes Multiple Conformational Changes to Regulate SNARE Binding, Complex Formation and Fusion"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Andreas Mayer (Université de Lausanne, Switzerland)
"Membrane Remodeling at Endosomes and Lysosomes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Heike Folsch (Northwestern University, United States)
"Role of AP-1 Isoforms in Recycling Endosome Biogenesis and Polarized Sorting"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Pilar Rivero-Rios (University of Michigan, United States)
"Recruitment of the SNX17-Retriever Recycling Pathway Regulates Synaptic Function and Plasticit"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Jonathan Friedman (UT Southwestern Medical Center, United States)
"An Inside Job: A Mitochondrial Intermembrane Space Protein Facilitates Completion or Organelle Division"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
John Briggs (Max Planck Institute of Biochemistry, Germany)
"Electron Microscopy in Membrane Research"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Disease, Infections and Treatments
Discussion Leader: Fulvio Reggiori (Aarhus University, Denmark)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Lena Pernas (Max Planck Institute for Biology of Ageing, Germany)
"Evolution of the Outer Mitochondrial Membrane during Infection"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Tamara O'Connor (Johns Hopkins University School of Medicine, United States)
"Legionella Hijacks Host Cell Peroxisomes for Replication Vacuole Membrane Expansion and Integrity"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Neta Regev-Rudzki (Weizmann Institute of Science, Israel)
"The Invisible Network: How Extracellular Vesicles Help Malaria Parasites Thrive and Survive"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Jens Brüning (Max Planck Institute for Metabolism Research, Germany)
"Ceramide-Dependent Regulation of Mitochondrial Function in Metabolism"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Noboru Mizushima (The University of Tokyo, Japan)
"Organelle Degradation in the Eye Lens"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mechanisms of Organelle Identity
Discussion Leaders: Chris Fromme (Cornell University, United States) and Anne Spang (Biozentrum, University of Basel, Switzerland)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Elvan Böke (Centre for Genomic Regulation (CRG), Spain)
"Oocytes Sequester Aggregated Proteins in Degradative Super-Organelles"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
David Murray (University of Dundee, United Kingdom)
"Cell Structure Organization and Polarized Trafficking"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Lauren Jackson (Vanderbilt University, United States)
"Molecular Role of Tepsin in Membrane Trafficking and Autophagy"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Adam Hughes (University of Utah, United States)
"Mitochondrial Remodeling During Nutrient Stress"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Sean Munro (MRC Laboratory of Molecular Biology, United Kingdom)
"Transport Vesicle Targeting to Membranes"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Fred Hughson (Princeton University, United States)
"Tether: SNARE Collaboration in Membrane Trafficking"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Bhawik Jain (Vanderbilt University, United States)
"P4-ATPase Control over PI4P Membrane Asymmetry and Neomycin Resistance"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Jared Rutter (University of Utah, United States)
"Mitochondria, Metabolism, and Cellular Decisions"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Techniques in Molecular Membrane Biology
Discussion Leader: Adam Frost (Altos Labs & UCSF, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 7:55 pm
Sabrina Ergun (Princeton University, United States)
"Membrane Remodeling in the CO2-fixing Organelle, the Pyrenoid"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Jeanne Stachowiak (The University of Texas at Austin, United States)
"Flexible Protein Networks Organize and Remodel Membranes During Clathrin-Mediated Endocytosis"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Alanna Schepartz (University of California, Berkeley, United States)
"Peptide Delivery Across Membranes"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Florian Fröhlich (Universität Osnabrück, Germany)
"Structural and Functional Analysis of Sphingolipid Metabolism Enzymes"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Manu Leonetti (Chan Zuckerberg Biohub, United States)
"A Spatial Map of the Human Proteome from Systematic Immuno-Capture of Native Organelles"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure