HETEROTRIMERIC G PROTEINS
- Discussion Leader: Henry Bourne, UCSF - "New developments in G protein biology"
- Steve Sprang , UT Southwestern - "G protein heterotrimer"
- Heidi Hamm , U. Illinois at Chicago - "G protein structure-activity"
- M. Koelle, MIT - "eg110: an SST2-like negative regulator of G protein-coupled receptor signaling"
G PROTEIN-COUPLED RECEPTOR STRUCTURE
- Discussion Leader: R. Henderson, MRC - "Current understanding of protein-coupled receptor structure and activation"
- W. Hubbell, UCLA - "Spin labels as probes of GPCR structure and conformational change"
- Brian Kobilka, Stanford - "Fluorescent probes of GCPR conformational change"
- H. R. Kaback, UC Berkeley - "lac permease as paradigm. How far can mutagenesis takes us?"
- Christian Elling - "Use of metal-ion binding sites to infer structure"
TRAFFICKING, CHANNELS AND APOPTOSIS
- Discussion Leader: Lee Limbird, Vanderbilt - "Basis for distinct trafficking patterns of adrenergic receptors"
- Marc Caron, Duke - "Arrestins as trafficking molecules"
- Lily Jan , UCSF - "G protein regulated K channels"
- David Goeddel, Tularik - "Signaling of apoptosis"
KINASES
- Discussion Leader: Gary Johnson, National Jewish Center, Denver - "MAP kinases"
- Lewis T. Williams, Chiron & UCSF - "Growth factor receptor signaling"
- Arthur Weiss, UCSF - "T cell receptor signaling -ZAP70lck"
- Zhaodan Cao, Tularik - "New IL-1 receptor-associated kinase"
- P. Kofuji - "Deactivation kinetics of GIRK accelerated by RGS proteims"
- Mark Von Zastrow - "A novel protein that regulates adrenergic signaling"
DIVERSE ROLES OF SMALL G PROTEINS: SIGNALING, TRAFFICKING, AND POLARITY
- Discussion Leader: Ira Herskowitz, UCSF - "Role of small G proteins in cell polarity"
- Gary Bokoch , Scripps - "Rac/Rho GTPases"
- Sandra Schmidt, Scripps - "Dynamin"
- Mark Ginsberg, Scripps - "Integrin signaling"
TRANSCRIPTIONAL REGULATION/NOVEL SYSTEMS
- Discussion Leader: James Darnell, Rockefeller U. - "Stat pathways"
- Michael Karin, UCSD - "AP1 regulation"
- Chris Glass , UCSD - "Retinoic acid receptors"
- Stefan Offermans - "Genetic dissection of signaling by Galphaq and Galpha12 family members"
- Lila Collins - "Galpha12 and low molecular weight G proteins mediate thrombin signaling"
- Peter Coward - "Receptors engineered for "private" signaling in vivo"
- Israel Charo - "Chemokine receptors as co-receptors for HIV"
GENETIC MODELS
- Discussion Leader: Robert Lefkowitz, Duke - "Genetic dissection of adrenergic signaling in mice"
- Nancy Hopkins, MIT - "Zebrafish as a genetic model system"
- M. Yanagisawa, UT Southwestern - "Genetic dissection of the endothelium pathway"
- Peter Devreotes, John Hopkins - "Proteins essential for cyclase activation by chemokine receptors"
- Steve Liggett - "Polymorphisms in human adrenergic receptors"
APPROACHES TO THERAPEUTIC DEVELOPMENT
- Discussion Leader: Fred Cohen, UCSF - "Structure-based drug design"
- Jonathan Ellman, UC Berkeley - "Combinatorial chemistry"
- Chaitan Khosla, Stanford - "Combinatorial biosynthesis"
- Stephen Chang, Chiron/Viagene - "Gene therapy"
SPECIAL WORKSHOP: IMPACT OF THE GENOME PROJECT ON SIGNALING RESEARCH
- Discussion Leader: Ira Herskowitz
Keynote Lecture
- Rick Lifton, Yale - "Molecular genetics of human hypertension"
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