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Molecular Pharmacology

Gordon Research Conference

January 28 - February 2, 2007
Chair Mark von Zastrow
Vice Chairs Susanna Cotecchia and Joel Bockaert
Ventura Beach Marriott
2055 Harbor Boulevard
Ventura, California, United States
 Venue and Travel Information

Conference Description

The Gordon Research Conference on Molecular Pharmacology will return in 2007 to its previous home in Ventura, California. This conference, which convenes every two years, is a major forum for discussing the most recent progress in signal transduction and molecular pharmacology research. The Molecular Pharmacology GRC has traditionally focused on G protein-mediated signaling and seven-transmembrane receptors. The scope of the conference is broad, however. Topics range from structural and biochemical advances, to systems-level pharmacology and physiology, to pathophysiology and therapeutics. Researchers from both academia and industry are encouraged to apply. Poster presentations are strongly encouraged and will be prominently featured.

Conference Program

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmMolecular Dynamics
Session chairs: Brian Kobilka (Stanford) & Thue Schwartz (University of Copenhagen)
7:35 pm - 7:45 pm Introduction
7:45 pm - 8:10 pm Roger Sunahara (University of Michigan)
"GPCRs reconstituted into HDL: finally an approach to study GPCR biophysics in membranes"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm David Ferrens (Oregon Health Sciences University)
"Lipid effects on rhodopsin self-association and arrestin binding"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Martin Lohse (University of Wuerzburg, Germany)
"Analysis of GPCR signaling with FRET"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructure
Session chair: Steve Sprang (UT Southwestern)
9:00 am - 9:25 am Kris Palczewski (Case Western Reserve University)
"Active form of rhodopsin"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Daniel Mueller (MPI Dresden, Germany)
"Providing functional fingerprint and activation mechanisms of single membrane proteins"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Gebhard Schertler (MRC Cambridge, UK)
"Structure of a thermally stabilised rhodopsin expressed in mammalian cells determined by micro-crystallography"
10:35 am - 10:45 am Discussion
10:45 am - 11:10 am John Tesmer (University of Michigan)
"Receptor-mediated activation of G protein-coupled receptor kinases"
11:10 am - 11:20 am Discussion
11:20 am Group Photo / Coffee Break
11:40 am - 12:05 pm Jean-Philippe Pin (University of Montpellier, France)
"GPCR oligomerisation, two or more? Insights from the GABAB receptor"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Marta Filizola (Cornell University)
"Dynamic Models of G-Protein Coupled Receptor Oligomers: Insights from Normal Mode Analysis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmSignaling networks
Session chair: Elliot Ross (UT Southwestern)
7:30 pm - 7:40 pm Introduction
7:40 pm - 8:05 pm John Scott (Vollum Institute / Oregon Health Sciences University)
"Cell signaling in space and time"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Michel Bouvier (University of Montreal)
"Ligand biased efficacy at G protein-dependent and independent signaling of 7TM receptors"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Steve Lanier (Louisiana State University)
"Receptor-independent activators of heterotrimeric G-protein signaling"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Greg Tall (UT Southwest)
"Identification and analysis of the minimal Ric-8 GEF domain"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPhysiological diversity
Session chair: Susanna Cotecchia (University of Lausanne, Switzerland)
9:00 am - 9:10 am Introduction
9:10 am - 9:35 am David Julius (University of California at San Francisco)
"Nucleotide receptors and response to tissue damage"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Ulrike Gaul (Rockefeller University)
"GPCR signaling in Drosophila blood-brain barrier formation"
10:10 am - 10:20 am Discussion
10:20 am - 10:35 am Stephen Liberles (Fred Hutchinson Cancer Research Center / University of Washington)
"A novel family of sensory receptors in the nose"
10:35 am - 10:45 am Discussion
10:45 am - 11:00 am Tracy Handel (University of California at San Diego)
"The Emerging Role of the Chemokine Receptor, CXCR4, in Cancer Metastasis"
11:00 am - 11:10 am Discussion
11:10 am Coffee Break
11:30 am - 11:40 am Introduction to Keynote speaker
11:40 am - 12:20 pm Keynote talk: Lee Limbird (Meharry Medical College)
"Preconceived notions of diversity: from signaling mechanisms to the future of biomedical research"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmLigand diversity and selectivity
Session chair: Joel Bockaert (University of Montpellier, France)
7:30 pm - 7:40 pm Introduction
7:40 pm - 8:05 pm Jerold Chun (Scripps Research Institute)
"New aspects of lysophospholipid receptors and biology"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Bryan Roth (University of North Carolina)
"How best to achieve ligand selectivity: engineered ligands or evolved receptors?"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Taroh Iiri (University of Tokyo, Japan)
"Modulation of a GPCR with multiple active conformations"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Graciela Pineyro (University of Montreal)
"DORs may adopt ligand-specific conformations that are differentially regulated by Src"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMembrane organization and trafficking
Session chair: Sudha Shenoy (Duke University)
9:00 am - 9:10 am Introduction
9:10 am - 9:35 am Jeff Benovic (Thomas Jefferson University)
"Regulation of receptor signaling and trafficking by arrestins"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am JoAnn Trejo (University of North Carolina)
"Protease-activated receptor signaling and endocytic sorting"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:45 am - 11:10 am Henrik Dohlman (University of North Carolina)
"G protein signaling at the endosome"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Paul Insel (University of California at San Diego)
"GPCR signaling microdomains in lipid rafts/caveolae"
11:45 am - 11:55 am Discussion
11:55 am - 12:05 pm Jeremy Reiter (University of California at San Francisco)
"The Smoothened/Frizzled family and the primary cilium: Regulation of 7TM function at the cell's antenna"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Patricia Hinkle (University of Rochester)
"Receptor Phosphorylation is Potentiated by Microaggregation"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmEffector systems
Session chair: Diane Barber (University of California at San Francisco)
7:30 pm - 7:40 pm Introduction
7:40 pm - 8:05 pm Silvio Gutkind (National Institutes of Health)
"G protein signaling and vascular permeability: lessons from a virally pirated GPCR"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Orion Weiner (University of California at San Francisco)
"A self-organizing circuit generates cell movement"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Joan Heller-Brown (University of California at San Diego)
"GPCR signaling through Rho and PLC epsilon"
9:15 pm - 9:25 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeural signaling and behavior
Session chair: Marc Caron (Duke University)
9:00 am - 9:10 am Introduction
9:10 am - 9:35 am Nigel Bunnett (University of California at San Francisco)
"Proteolytic regulation of neurogenic inflammation and hyperalgesia"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Francis Lee (Cornell University)
"Neurotrophin signaling in complex behaviors"
10:10 am - 10:20 am Discussion
10:20 am - 10:30 am Martin Beaulieu (Duke University)
"Pharmacological disruption of beta-arrestin mediated dopamine receptor signaling"
10:30 am - 10:35 am Discussion
10:35 am Coffee Break
10:55 am - 11:20 am Jennifer Whistler (Ernest Gallo Research Center / University of California)
"GPCR trafficking and addiction"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Laura Bohn (Ohio State University)
"Activating receptors without recruiting arrestins: implications for opioid analgesics"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
12:30 pmLunch
1:30 pm - 6:00 pmFree Time / Activity
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session
7:30 pm - 8:00 pm Olivier Civelli (University of California at Irvine)
"Poster Awards (in honor of Hubert Van Tol)"
8:00 pm - Keynote talk: Shaun Coughlin (University of California at San Francisco)
"GPCRs in homeostasis and development"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Contributors

Allergan
Amgen
ARYx Therapeutics
Astrazeneca Canada
Bristol-Meyers Squibb
Cisbio
Institut de Recherches Servier
Medarex
Memory Pharmaceuticals
National Institutes of Health
Novartis Institutes for Biomedical Research
Roche Palo Alto
Theravance

Conference Links

Conference History
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