SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Towards crystal clear views of receptors |
7:40 pm - 8:00 pm | Discussion Leader: Brian K. Kobilka (Stanford University, USA) "Introduction" |
8:00 pm - 8:25 pm | Gebhard Schertler (MRC, UK)
"Structure of the thirdintracellular loop of the beta1-adrenergic receptor: Implications for pharmacology" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Klaus-Peter Hofmann (University of Berlin, Germany)
"Signal transfer from receptor to G protein: Insights from spectroscopic and structural studies on rhodopsin" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Rob Lane (University of Leiden, The Netherlands)
"The crystal structure of the adenosine A2A receptor. Implications for GPCR drug design" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Activation and molecular dynamics of signaling proteins |
9:00 am - 9:10 am | Discussion Leader: Ongun Onaran (University of Ankara, Turkey) "Introduction" |
9:10 am - 9:35 am | Martin Lohse (University of Wuerzburg, Germany)
"Mechanisms and kinetics of G-protein-coupled receptor activation" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Jean-Philippe Pin (CNRS, Montpellier, France)
"Intramolecular transduction in metabotropic glutamate receptors" |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break / Group Photo |
11:00 am - 11:25 am | Olivier Lichtarge (Baylor College of Medicine, USA)
"Separation of ligand binding and sensitivity in psychotropic receptors" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Francesca Fanelli (University of Modena and Reggio Emilia, Italy)
"Receptor impact on G protein dynamics" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Xavier Deupi (Universitat Autonoma de Barcelona, Spain)
"Impact of ligand entry pathways on selectivity in beta adrenergic receptors" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | Molecular organization of signaling proteins |
5:30 pm - 5:40 pm | Discussion Leader: Paul Insel (UCSD, USA) "Introduction" |
5:40 pm - 6:05 pm | Jean-Louis Banères (University of Montpellier, France)
"Molecular organization of a GPCR dimer and its complex with G proteins" |
6:05 pm - 6:15 pm | Discussion |
6:15 pm - 6:40 pm | Roger Sunahara (University of Michigan, USA)
"Allosteric regulation of ligand binding by G proteins" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Francoise Bachelerie (Institut Pasteur, France)
"CXC chemokine receptors control of cell migration and human primary immunodeficiencies" |
7:15 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling: a space and time perspective |
9:00 am - 9:10 am | Discussion Leader: Stefano Marullo (Institut Cochin, France) "Introduction" |
9:10 am - 9:35 am | Michel Bouvier (University of Montreal, Canada)
"Assembly and conformational rearrangements of GPCR signalling modules underlying ligand-biased responses" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Graeme Milligan (University of Glasgow) |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Gerald Zamponi (University of Calgary, Canada)
"Signaling complexes between N-type calcium channels and G-protein coupled receptors" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Eric Trinquet (CISBIO, France)
"New Fluorescent Technologies to address GPCR Complexity" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Maria Waldhoer (University of Graz, Austria)
"Signaling of GPR55: discovering 'old' ligands using the EPIC® technology" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | Regulatory mechanisms and trafficking of receptors |
5:30 pm - 5:40 pm | Discussion Leader: Mark Rasenick (University of Illinois Chicago, USA) "Introduction" |
5:40 pm - 6:05 pm | Mark von Zastrow (UCSF, USA)
"Molecular sorting of GPCRs after endocytosis" |
6:05 pm - 6:15 pm | Discussion |
6:15 pm - 6:40 pm | JoAnn Trejo (UCSD, USA)
"Protease-selective signaling by protease-activated receptor-1" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Jeff Benovic (Thomas Jefferson University, USA)
"Novel functions of arrestins" |
7:15 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Diversity of physio-pathological implications |
9:00 am - 9:10 am | Discussion Leader: Joan Heller Brown (UCSD, USA) "Introduction" |
9:10 am - 9:35 am | J. Silvio Gutkind (NIH, USA)
"G-protein coupling in tumor growth and metastatic spread" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Martine Smit (University of Amsterdam, The Netherlands)
"Virus-encoded chemokine receptors activate inflammatory and oncogenic signaling pathways" |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Diane Barber (UCSF, USA)
"Signaling to the cytoskeleton by pH sensing" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Sabine Costagliola (Université Libre de Bruxelles, Belgium)
"Glycoprotein hormone receptors: from mutations to diseases" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Federico Mayor (University of Madrid, Spain)
"A Role for G protein-coupled Receptor Kinase 2 in Cell Cycle Progression" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:30 pm | Free Time |
6:30 pm - 7:30 pm | Keynote lecture |
6:30 pm - 6:35 pm | Discussion Leader: Paul Insel (UCSD) "Introduction" |
6:35 pm - 7:15 pm | Robert J. Lefkowitz (Duke University, USA)
"New Paradigms for 7TM Receptor Signaling and Regulation: Challenges for the Structural Biology Era" |
7:15 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of brain functions and metabolism in animal models |
9:00 am - 9:10 am | Discussion Leader: Michael Freissmuth (University of Vienna, Austria) "Introduction" |
9:10 am - 9:35 am | Marc Caron (Duke University, USA)
"Animal Models of Monoamine-Associated Behaviors: Signaling and drug actions" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Brigitte Kieffer (University of Strasbourg, France)
"Knock-in mice to track opioid receptors in vivo" |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Bernhard Bettler (University of Basel, Switzerland)
"Molecular basis for functional and pharmacological heterogeneity among native GABA-B receptors" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Jurgen Wess (NIH, USA)
"Studies with muscarinic and V2 vasopressin receptor mutant mice" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Kristina Lorenz (University of Wuerzburg, Germany)
"G-beta/gamma-induced cardiac hypertrophy" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:30 pm | Free Time |
5:30 pm - 7:30 pm | Drug diversity and the receptorome |
5:30 pm - 5:40 pm | Discussion Leader: Ad IJzermann (University of Leiden) "Introduction" |
5:40 pm - 6:05 pm | Bryan Roth (University of North Carolina Chapel Hill, USA)
"Evolving GPCRs for spatiotemporal control of neuronal signaling" |
6:05 pm - 6:15 pm | Discussion |
6:15 pm - 6:40 pm | Guy Servant (Senomyx, USA)
"The Identification of Novel Taste Modulators using Cell Based Assays for Taste Receptors" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Thue Schwartz (University of Copenhagen, Denmark)
"7TM chemo-sensors on enteroendocrine cells as drug targets" |
7:15 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |