SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Receptor structure: What it says about function |
| Discussion Leader: Jean-Philippe Pin (Institut de Génomique Fonctionnelle INSERM) |
7:40 pm - 8:05 pm | Krys Palczewski (Case Western Reserve University) "G protein-coupled receptor rhodopsin and its G protein transducin" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Brian Kobilka (Stanford University School of Medicine) "Structure and dynamics of GPCRs: Insights from the human β2 adrenoceptor" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Chris Tate (University of Cambridge) "Agonist- and antagonist-bound structures of a thermostabilised β1-adrenergic receptor" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Novel methods and new insights regarding GPCR signaling |
| Discussion Leader: Mark von Zastrow (University of California San Francisco) |
9:00 am - 9:30 am | Martin Lohse (University of Würzburg) "Microscopic approaches to spatio-temporal analysis of GPCR signaling" |
9:30 am - 9:45am | Discussion |
9:45 am - 10:15 am | Coffee Break / Group Photo |
10:15 am - 10:45 am | Marvin Gershengorn (NIDDK, NIH) "Persistent Signaling by TSH and TRH Receptors" |
10:45 am - 11:00 am | Discussion |
11:00 am - 11:30 am | Thue Schwartz (University of Copenhagen) "Molecular basis for biased signaling: Dissection of micro-switch function in 7TMs" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Tania Vu (School of Medicine, Oregon Health and Science University) "Molecular Imaging of GPCR trafficking using Quantum Dots" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cellular organization of receptors and signaling proteins: molecular and functional microdomains I |
| Discussion Leader: Mark Rasenick (University of Illinois Chicago) |
7:30 pm - 8:00 pm | Stefano Marullo (Université Paris Descartes) "The BBB partnership: Bacteria, β2-adrenoceptor, β-arrestin to open and cross the Blood Brain Barrier" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Hemal Patel (University of California San Diego) "Caveolins in molecular compartmentation: implications for stress adaptation and disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jonathan Stamler (Case-Western Reserve Univ) "Regulation of GPCR signaling by S-nitrosylation" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling via G-proteins: what’s old is new |
| Discussion Leader: Graeme Milligan (University of Glasgow) |
9:00 am - 9:30 am | Thomas Sakmar (Rockefeller University) "Using genetically-encoded non-natural amino acids to examine receptor activation" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Roger Sunahara (University of Michigan) "G proteins and conformational selectivity of GPCRs" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Alan Smrcka (University of Rochester) "Biasing GPCR Signals with Small Molecule G Protein β/γ Modulators" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Ken Harden (University of North Carolina) "Mechanism of activation and inactivation of the Gq and PLC-beta signaling complex" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cellular organization of receptors and signaling proteins: molecular and functional microdomains II |
| Discussion Leader: Michel Bouvier (Université de Montréal) |
7:30 pm - 8:00 pm | JoAnn Trejo (University of California San Diego) "Diversity of protease-activated receptor signaling" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Steve Ferguson (University of Western Ontario) "Role of recycling in CRF1-dependent regulation of anxiety behavior via sensitization of 5-HT2 receptor signaling" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Dermot Cooper (University of Cambridge) "Organization of signalling microdomains by adenylyl cyclases" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Disease-related changes in receptor signaling: therapeutic implications |
| Discussion Leader: Joel Bockaert (Institute of Functional Genomics INSERM) |
9:00 am - 9:30 am | Stephen Liggett (University of Maryland) "Bitter Taste Receptors on Airway Smooth Muscle Transduce a Super- localized Ca++ Signal to BKCa that Bronchodilates: A highly effective treatment strategy for asthma" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Shaun Coughlin (University of California San Francisco) "Protease-Activated Receptors" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Susan George (University of Toronto) "The dopamine D1-D2 receptor heteromer: Novel signaling complex provides insight into brain function" |
11:30 am - 11:45 am | Discussion |
11:45am - 12:15 pm | Tom Wilkie (University of Texas Southwestern Medical Center) "RGS genes-HTS biomarkers for pancreas development, cancer and diabetes mellitus" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm - 9:00 pm | Keynote lecture |
| Discussion Leader: Paul Insel (University of California San Diego) |
8:00 pm - 8:40 pm | Michel Bouvier (Université de Montréal) "Biogenesis and assembly of GPCRs; implications for signaling efficacy and functional selectivity" |
8:40 pm - 9:00 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New drugs derived from new ideas and new findings |
| Discussion Leader: Brian Kobilka (Stanford University) |
9:00 am - 9:30 am | Arthur Christopoulos (Monash University) "Functional and Structural Approaches to Studying GPCR Allosterism" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Lakshmi Devi (Mount Sinai School of Medicine) "Exploring the Opioid Receptor Heteromer as Novel Drug Targets" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 pm | Sue Kinnamon (Colorado State University) "GPCR signaling in taste cells" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Gerda Breitwieser (Geisinger Clinic) "Agonist regulation of calcium sensing receptor signaling" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Animal models of GPCRs in disease |
| Discussion Leader: Brigitte Kieffer (Institut de Génétique et de Biologie Moléculaire et Cellulaire) |
7:30 pm - 8:00 pm | Emiliana Borrelli (University of California Irvine) "Pre-synaptic versus post-synaptic dopamine D2 receptor signaling and neurological/neuropsychiatric disorders" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Ping-Yee Law (University of Minnesota) "The in vivo consequences of opioid agonist-dependent signaling" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Amynah Pradhan (University of California Los Angeles) "Ligand-directed trafficking of the delta opioid receptor in vivo: two paths towards analgesic tolerance" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Miho Terunuma (Tufts University) "GABAB receptor phosphorylation by AMP-dependent protein kinase modulates synaptic plasticity and spatial memory formation" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |