Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Future Prospects in GPCR-Biology and Drug Discovery
7:40 pm - 8:15 pm
"New Technologies in Drug Discovery and Translation Expand the Druggable Genome"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:00 pm
"Hallucinating Ligands for Psychedelic Receptors"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Molecular Insights into the Trafficking and Signaling of G Protein-Coupled Receptors That Localize to Neuronal Primary Cilia"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Systems Biology and AI in GPCR-Based Disease and Treatments
9:00 am - 9:20 am
"A Systems Approach to Understanding GPCR Signaling"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Predicting GPCR Structure and Functional Outcomes with Artificial Intelligence (AI) and Computer Simulations"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Mathematical Models of Signaling for Drug Discovery: Deconvolution of Kinetic Context in Apparent Biased Agonism"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"A Promiscuous Bitter Taste Receptor - Agonists, Antagonists and Odorous Surprises"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"New Biosensor Generations for the Sub-Cellular Detection of Functionally Selective GPCR Signal Propagation"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Data Science Approaches to GPCR Signalling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"GPCRs in the Era of Biobanks"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Chemogenetic Approach Reveals a GPCR-Gas-PKA Signaling Axis Promoting T Cell Dysfunction and Cancer Immunotherapy Failure"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging GPCR Drug Targets
6:00 pm - 6:25 pm
"Conformational Dynamics of Frizzleds Drive Receptor Activation and Pathway Selectivity"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Exploiting Drug Delivery to Target Subcellular GPCR Signalosomes in Pain"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
"Context-Dependent Requirement of G Protein Coupling for Latrophilin-2 in Target Selection of Hippocampal Axons"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
"Elucidating The GPCR Interactome"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structural Basis of Receptor Function
9:00 am - 9:20 am
"Structural Approaches to Deciphering the Nature of Class B Receptor Biology"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Conformational Selection in ACKR3 Activation and Inhibition by Ligands Large and Small"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Activation of the Class D Fungal GPCR Dimer Ste2"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Conformational Selection Mechanism of Peptide-GPCR Binding: The Case of NPY Binding to Y1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Employing Nanobodies to Functionally Modulate Angiotensin Receptor Signalling"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Allosteric Ligands Communicate with Orthosteric Agonist by Exploring Protein–Ligand Dynamics of Human Bradykinin 1 Receptor"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Advances in the Structure Determination of Effector Complexes and GPCR Signaling Complexes"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"The First Isoform Specific Disease Model and A New Gas Biosensor That Shines New Light on Intracellular G Protein Conformation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
GPCR Intracellular Signaling
6:00 pm - 6:25 pm
"Illuminating the Biochemical Activity Architecture of the Cell"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Structural and Functional Insights into Atypical Interaction and Activation of Ăź-arrestins with Seven Transmembrane Receptors"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Decoding Cellular GPCR Responses Using Nanobody Sensors and Modulators"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:55 pm
"Seeing Scents: Towards an Atomic Understanding of Olfaction"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Novel Aspects of GPCR Drug Discovery"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Following the Rabbit into Chemical Space"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Tissue Specific Outcomes of Activation of Free Fatty Acid Receptor 2"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Molecular Determinants of Arrestin-Mediated Dopamine D3R Modulation of the T-type Ca2+ Channel CaV3.2"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"New Insights into GPCR Targets to Improve Obesity"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Biased Signaling Atlas and Community Guidelines"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Rational Design of Selective Inhibitors Targeting G Protein-Coupled Receptor Kinases"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Improved Analgesics Through scRNAseq-Guided Precision Pharmacology"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:25 pm
"Allosteric Modulation of Class C Receptors"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Novel Applications of Phosphosite-Specific GPCR Antibodies"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"GRK Knockout Cells: New Insights into GPCR Regulation"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:55 pm
"Removing the GPCR-Mediated Brake on Exocytosis Enhances Insulin Action, Promotes Adipocyte Browning, and Protects Against Diet-Induced Obesity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Advanced Approaches in GPCR Research
9:00 am - 9:20 am
"Untangling the GPCR Puzzle with Light: From Endosomes to Signalling Nanodomains"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"What SDFL Has Taught Us About Arrestin Activation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Autoregulation of GPCR Signaling Through the Third Intracellular Loop"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Spatiotemporal GPCR Signaling at the Nanometer Scale"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Receptors on the Move; The Convergence of Extracellular Vesicle and GPCR Biology"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Unravelling M1 Muscarinic Receptor Phospho-Signaling in Neurodegeneration"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Functional Opioid Fingerprints in the Awake Mouse Brain"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Session in Memory of Marc Caron: Advances in Receptor Physiology and Translation
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"Pharmacological Diversification of Opioid Receptor Signaling"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Targeting Muscarinic Receptors In Neuropsychiatric Disease"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"G Protein-Coupled Receptors as Targets for the Treatment of Neurodegenerative Diseases"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Know thy GPCR: Future Directions of the Field"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure