| SATURDAY |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Lecture |
| Discussion Leaders: Jean Philippe Pin (IGF, CNRS-INSERM, France) and Elena Monica Borroni (Humanitas Clinical and Research, Italy) |
| 3:15 pm - 3:45 pm | Michel Bouvier (Institut de Recherche en Immunologie et Cancérologie, Canada)
"Folding and Traficking of GPCR; Targets for Drug Discovery?"
|
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | From the Structure to GPCRs Function |
| Discussion Leaders: Ron Dror (D.E. Shaw Research, New York, NY USA) and Robert Lane (Monash Institute Of Pharmaceutical Sciences, Australia) |
| 5:30 pm - 5:50 pm | Daniel Wacker (The Scripps Research Institute)
"Structural Basis of Hallucinogen Signaling through Serotonin and Opioid Receptors"
|
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | A.J. Venkatakrishnan (MRC Laboratory of Molecular Biology)
"Molecular signatures of G protein-coupled receptors"
|
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Martin Ostermaier (Paul Scherrer Institute)
"Arrestin rhodopsin binding at single amino acid resolution"
|
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Miriam Peeters (Leiden Academic Centre for Drug Research)
"A general, tethered inverse agonist model for adhesion 7TM receptor activation - based on selective expression in enteroendocrine cells"
|
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:30 am | GPCRs in cell communication |
| Discussion Leaders: Martin Lhose (University of Wuerzburg, Germany) and Nicola Smith (Victor Chang Cardiac Research Institute, Australia) |
| 9:00 am - 9:20 am | Abla Benleulmi (INSERM U1016)
"Identification of new melatonin receptor functions by protein interactome mining"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sean Peterson (Duke University)
"The physiological and evolutionary significance of dopamine 2 receptor functional selectivity"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Aaron Overland (University of California, San Diego)
"GPCRs and Heterotrimeric G Proteins Directly Regulate Membrane Type-1 Matrix Metalloprotease"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | GPCRs in vivo: Physiology and Diseases |
| Discussion Leaders: Brigitte Kieffer (IGBMC, Strasbourg, France) and Aaron Snead (University of California, USA) |
| 10:30 am - 10:50 am | Amantha Thathiah (Catholic University of Leuven)
"Beta-arrestin 2 regulates GPCR function in Alzheimer's disease"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | GPCRs in vivo: Physiology and Diseases (continued) |
| Discussion Leader: Brigitte Kieffer (IGBMC, Strasbourg, France) |
| 1:30 pm - 1:50 pm | Camilla West (Imperial College London)
"Regulation of LH/CG receptor signaling in human endometrium and perturbations in recurrent pregnancy loss"
|
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Stephanie Dusaban (University of California, San Diego)
"Phospholipase C-epsilon links G-protein coupled receptor activation to inflammatory responses in astrocytes and in models of CNS injury and disease"
|
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
