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Molecular Pharmacology (GRS)

Gordon Research Seminar

New Frontiers in GPCR Signaling: From Biased Agonism to Disease Progression

January 31 - February 1, 2015
Chairs Neil J. Grimsey and Stephanie S. Dusaban
Ventura Beach Marriott
2055 Harbor Boulevard
Ventura, California, United States
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Molecular Pharmacology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This year’s GRS will focus on new advancements in the field of G-protein coupled receptors (GPCRs). The seminar series will examine 1) the initiation of GPCR signaling at the biochemical and structural level, 2) novel intracellular signaling pathways downstream of GPCR activation and 3) the functional implications of GPCRs in disease. All of these topics will facilitate discussion of the importance of understanding GPCR function for drug discovery.

Related Meeting

This GRS will be held in conjunction with the "Molecular Pharmacology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Probing G Protein Coupled Receptors
Discussion Leaders: Jo Ann Trejo (University of California, San Diego, USA) and Camilla West (Imperial College London, United Kingdom)
3:45 pm - 3:50 pmIntroduction by Discussion Leader: Opening Remarks
3:50 pm - 4:20 pmKeynote: Brian Kobilka (Stanford University, USA)
"Probing G Protein Coupled Receptors: A Few of My Favorite Experiments"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Initiation of GPCR Signaling at the Biochemical and Structural Level / Novel Intracellular Signaling Pathways Downstream of GPCR Activation
Discussion Leaders: Richard Neubig (Michigan State University, USA), Ines Liebscher (University of Leipzig, Germany), Manojkumar Puthenveedu (Carnegie Mellon University, USA) and Ross Corriden (University of California, San Diego, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmAndrea Ahles (Technische Universitat Munchen, Germany)
"Interhelical Interaction and Receptor Phosphorylation Determine Activation Kinetics of Different Human β1-Adrenoceptor Variants"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMarlies Hager (University of Wisconsin, Madison, USA)
"a/β-Peptide Analogues of GLP-1 Are Bioactive Agonists of the GLP-1 Receptor"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRoshanak Irannejad (University of California, San Francisco, USA)
"Conformational Biosensors Reveal Adrenoceptor Signaling from Endomembranes"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:05 pmIntroduction by Discussion Leader
9:05 pm - 9:25 pmRichard Carr (Thomas Jefferson University, USA)
"Biased Signaling Through the β2-Adrenergic Receptor Using Pepducins"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNovel Intracellular Signaling Pathways Downstream of GPCR Activation (continued) / The Functional Implications of GPCRs in Disease
Discussion Leaders: Manojkumar Puthenveedu (Carnegie Mellon University, USA), Ross Corriden (University of California, San Diego, USA), Laura Bohn (The Scripps Research Institute, USA) and Simone Promel (University of Leipzig, Germany)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amRabia Malik (University of Michigan, USA)
"Defining the Rules of GPCR - G-Protein Interaction"
9:25 am - 9:30 amDiscussion
9:30 am - 9:50 amKasturi Pal (University of Texas Southwestern Medical Center, USA)
"Tonic and Sonic Hedgehog-Regulated Mechanisms Determine Ciliary Trafficking of G-Protein Coupled Receptor Gpr161"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amDaniel Shiwarski (Carnegie Mellon University, USA)
"Unlocking the DOR to the Surface: Regulated Surface Delivery of the δ-Opioid Receptor"
10:20 am - 10:30 amDiscussion
10:30 am - 10:35 amIntroduction by Discussion Leader
10:35 am - 10:55 amMario Rossi (National Institutes of Heath, USA)
"Physiological Relevance of Hepatic Gi Signaling: Studies with Novel Mutant Mouse Models"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmThe Functional Implications of GPCRs in Disease (continued)
Discussion Leaders: Laura Bohn (The Scripps Research Institute, USA) and Simone Promel (University of Leipzig, Germany)
1:30 pm - 1:50 pmQingtong Wang (Anhui Medical University, China)
"Hyperinsulinmia Impaired Heart Function via Elevating PDE4D Expression Through β2 Adrenergic Receptor Signaling"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmBelma Hot (Karolinska Institutet, Sweden)
"FZD10 and Vascular Development"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Contributors

Conference Links

Conference History Molecular Pharmacology
Additional Fee Info

Molecular Pharmacology
February 16 - 21, 2025


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