Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
How GPCR Structure Influences Function
Through the identification and study of GPCR protein structure, many important works have revealed how structure can influence receptor function. In this session, we will explore the structural basis for GPCR signaling, and how alterations in this structure can determine function.
3:15 pm - 3:20 pm
Introduction by Discussion Leader: How GPCR Structure Influences Function
3:20 pm - 3:35 pm
"Structural Basis for Arrestin Activation by G Protein-Coupled Receptors"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
"2A but Not 2B: Towards Structure-Based Discovery of New Serotonin Receptor Modulators"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The GPCR Tool Kit: Novel Techniques and Tools for GPCR Research
In all research, having the right tools can make or break a project. In this session, we will explore several novel tools and techniques that have been developed to aid the progress of GPCR research.
5:30 pm - 5:35 pm
Introduction by Discussion Leader: Novel Techniques and Tools for GPCR Research
5:35 pm - 5:50 pm
"Deciphering G Protein-Coupled Receptor (GPCR) Signal Transduction Through Solution NMR"
5:50 pm - 5:55 pm
Discussion
5:55 pm - 6:10 pm
"Jumping Spider Rhodopsin, a New Tool for Optogenetics"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:30 pm
"The Use of Fluorescence Correlation Spectroscopy to Characterise Lipidated Ligands"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
"Using BRET and Nluc to Monitor Endogenous Protein Interactions and Receptor Trafficking"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:00 pm
Introduction by Discussion Leader: Trafficking and Signaling: Location Matters
7:00 pm - 7:15 pm
"Super-Resolution Microscopy Reveals the Spatial Organization of mGlu4 Receptors at Presynaptic Active Zones"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
GPCR Signaling, Trafficking, and In Vivo Approaches
It is becoming increasingly evident that GPCRs can signal from not only the cell surface, but intracellular compartments. For this reason, the trafficking and localization of GPCRs likely plays a large role in GPCR physiology. Additionally, model systems are essential in determining how basic research can translate into clinical interventions. In this session, we will be presented with work highlighting these topics.
9:00 am - 9:05 am
Introduction by Discussion Leader: Trafficking and Signaling: Location Matters
9:05 am - 9:20 am
"Gq-Coupled GPCR Pathways Open New Avenues for the Modulation of Autophagy"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
"APPL1 Integrates Regulated GPCR Sorting and Signaling from the Very Early Endosome"
9:40 am - 9:45 am
Discussion
9:45 am - 9:50 am
Introduction by Discussion Leader: In Vivo Approaches and Biased Agonism
9:50 am - 10:05 am
"Characterization of Novel Biased KOR Agonist-Mediated Cell Signaling"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
"The Adhesion-GPCR Latrophilin/dCirl Affects the Development of the Drosophila NMJ"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
"Human Melatonin Type 2 Receptor Structural Insights Revealed by Natural Variants"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: A Look into the Future of GPCR Research
During this session, we will discuss the highlights from the talks and poster session through small group interactions and a panel discussion comprised of the discussion leaders. Attendees will be divided into 4 groups centered around their relevant session topics to recap the conference events with their discussion leader. Following this, we will reconvene and hold an open panel discussion about the future of GPCR research moderated by the conference chairs.
1:30 pm - 1:50 pm
Breakout Group Discussions
1:50 pm - 2:20 pm
Panel Discussion
The Future of GPCR Research
2:20 pm - 2:30 pm
Closing Remarks
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
