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Molecular Pharmacology (GRS)

Gordon Research Seminar

Structural, Computational and Pharmacological Approaches for Studying GPCR Function

February 9 - 10, 2019

Chairs

and

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Molecular Pharmacology is a unique forum for graduate students, postdocs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The meeting focuses on G protein-coupled receptor function from intracellular signalling to molecular function and structure. We invite researchers from different backgrounds to share their latest research with fellow early-career scientists.

The sessions will focus on:

GPCR Structure and Function
Computational Approaches for GPCR Modeling and Docking
GPCR Signaling and Pharmacology in vitro and in vivo

Related Meeting

This GRS will be held in conjunction with the "Molecular Pharmacology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Structural Biology of GPCRs This session will focus on the structure determination of GPCRs by X-ray crystallography and electron microscopy. Discussion Leaders: and
3:45 pm - 3:50 pm	Opening Remarks
3:50 pm - 4:05 pm	"XFEL Structures of the Human MT2 Melatonin Receptor Reveal Dual Ligand Entry Pathways"
4:05 pm - 4:10 pm	Discussion
4:10 pm - 4:25 pm	"Structural Basis of GCGR Activation"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	GPCR Functional Studies This session will explore the biochemical, and biophysical mechanisms of GPCR activation and regulation, and will also emphasize novel approaches for studying these mechanisms. Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:50 pm	"Assessing Biased Ligand Interactions Within the Transmembrane Domain Binding Site of the Glucagon-Like Peptide 1 Receptor"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	"Conformational States and Switching Dynamics in the A2A Adenosine Receptor Revealed by Single-Molecule Fluorescence"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:30 pm	"Experiment-Guided Molecular Modeling Reveals the Geometry of a Complete CXC Receptor-Chemokine Complex"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:50 pm	"Functional Evolution of Barcodes for G-Protein Selectivity Emerges from Sequence, Structure and Dynamics"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:10 pm	"Arrestin-3 Scaffolding of the JNK3 Cascade Suggests a Mechanism for Signal Amplification"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	GPCR Signaling and Pharmacology In Vitro and In Vivo Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:20 am	"Multisite Phosphorylation Is Required for Sustained Interaction with GRKs and Arrestins During Rapid µ-Opioid Receptor Desensitization"
9:20 am - 9:25 am	Discussion
9:25 am - 9:40 am	"Phosphorylation-Deficient G-Protein-Biased μ-Opioid Receptors Improve Analgesia and Diminish Tolerance but Worsen Opioid Side Effects"
9:40 am - 9:45 am	Discussion
9:45 am - 10:00 am	"cAMP Nanodomains Dictate Localized PKA Activity"
10:00 am - 10:05 am	Discussion
10:05 am - 10:20 am	"Negative Allosteric Modulation of Arrestin Recruitment to the β2-Adrenergic Receptor"
10:20 am - 10:25 am	Discussion
10:25 am - 10:40 am	"Interactions of Synthetic Cannabinoids with the 5HT1A Receptor"
10:40 am - 10:45 am	Discussion
10:45 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	GPCR Computational Biology This session will highlight new work seeking to improve our computational toolbox, and showcase how these tools may be used to further our understanding of GPCR function and the design of better therapeutics. Discussion Leader:
1:30 pm - 1:35 pm	Introduction by Discussion Leader
1:35 pm - 1:50 pm	"Alternative Splicing of GPCR Signalling Components as a Source of Tissue-Specific Receptor Pharmacology"
1:50 pm - 1:55 pm	Discussion
1:55 pm - 2:10 pm	"Novel Strategies to Elucidate Orphan Peptide-Receptor Signaling Systems"
2:10 pm - 2:15 pm	Discussion
2:15 pm - 2:25 pm	General Discussion
2:25 pm - 2:30 pm	Closing Remarks
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institute On Drug Abuse of the National Institutes of Health under Award Number R13DA047877. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Molecular Pharmacology

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