Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Career Journey in GPCR Drug Discovery
Discussion Leader: Nicole Perry-Hauser (Columbia University, United States)
3:15 pm - 3:45 pm
Fiona Marshall (Novartis, United States)
"A Career Following Technology Advances in GPCR Drug Discovery"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Biophysical and Computational Methods in GPCR Biology
Discussion Leaders: Timo De Groof (Vrije Universiteit Brussel, Belgium) and Romy Thomas (Max-Delbrück-Centrum for Molecular Medicine Berlin, Germany)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:00 pm
Ola Otun (CNRS / University of Montpellier, Institute for Functional Genomics (IGF), France, France)
"Linking the Conformational Landscape of Atypical Chemokine Receptor 3 (ACKR3) to Ligand Efficacy Using Hydrogen/Deuterium Exchange Mass Spectrometry"
6:00 pm - 6:10 pm
Discussion
6:10 pm - 6:30 pm
David Lee (UNC Chapel Hill, United States)
"Uncovering Non-Opioid GPCR-Mediated Analgesic Approaches Through Novel Pharmacological Targets and Tools"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Katie Sharrocks (Imperial College London, United Kingdom)
"A Mutagenesis Based Approach to Stabilise D2 Dopamine Receptor Homodimers"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
GPCR Signal Transduction
Discussion Leaders: Katarina Nemec (St Jude Children's Research Hospital, United States) and Preston Anderson (Duke University, United States)
9:00 am - 9:20 am
Emily Blythe (University of California, San Francisco, United States)
"A Discrete Mode of Endosomal GPCR Signaling That Does Not Require ß-arrestin"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lukas Grätz (Karolinska Institutet, Sweden)
"Pathway Selectivity in Frizzleds is Achieved by Conserved Microswitches Defining Pathway-Determining, Active Conformations"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Silvia Sposini (Imperial College London and Université de Bordeaux, France)
"Characterization of ß-Adrenergic Receptors Trafficking in Neurons in Real Time Using Imaging Techniques"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Alexei Sirbu (Max Delbrück Center for Molecular Medicine, Germany)
"Cell Swelling Serves as an Allosteric Modulator of ß2AR Signaling"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating STEM: Mentorship, Inclusion, and Scientific Careers
Discussion Leader: Brian Bender (Sosei Heptares, United Kingdom)
1:30 pm - 2:30 pm
Panel Discussion
Panel Discussion Navigating STEM: Mentorship, Inclusion, and Scientific Careers
Yamina Berchiche (Dr. GPCR, United States)
Alexander Hauser (University of Copenhagen, Denmark)
Madhulika Nambiar (Sosei Heptares, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes