Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Clinical Significance / Pharmacological Impact
Discussion Leader: Yu Toyoda (The University of Tokyo Hospital, Japan)
3:45 pm - 4:05 pm
Susan Bates (Columbia University, USA)
"Clinical Significance of Multidrug Efflux Pumps: From Biology to Cancer Therapies"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Neha Agrawal (Purdue University, USA)
"Targeting HIV Reservoirs in Brain by Inhibition of P-Glycoprotein at
the Blood-Brain Barrier"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Application to Drug Discovery
Discussion Leaders: Toshihisa Ishikawa (NGO Personalized Medicine and Healthcare, Japan) and Olga Lomovskaya (The Medicines Company, USA)
7:30 pm - 7:45 pm
Mavis Jiarong Li (University of Washington, USA)
"Biophysical Characterizations of Drug Binding Coupled to ATP Hydrolysis by P-Glycoprotein Reconstituted in Lipid Nanodiscs"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Anna Maria Barbuti (St. John's University, USA)
"Combination Therapy to Overcome ABC Transport Mediated Chemoresistance in a Colorectal Cancer Mouse Xenograft Model"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Allison Lange (Purdue University, USA)
"Overcoming P-Glycoprotein-Associated Resistance in Chronic
Myelogenous Leukemia with Dasatinib-Based Prodrugs"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Onat Kadioglu (Johannes Gutenberg University of Mainz, Germany)
"Activity of the Dietary Flavonoid, Apigenin, Against Multidrug-Resistant Tumor Cells as Determined by Pharmacogenomics and Molecular Docking"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Marine Schnetterle (French Armed Biomedical Research Institute (IRBA) / UMR-MD1, Aix Marseille Université, France)
"Phenothiazines Against Antibiotic Resistance: Impact on Efflux Pumps Expression of B. pseudomallei "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Erika Boulant (UMR-MD1, Aix Marseille Universite, France)
"Efflux Pumps as Tools to Increase Biofuel Tolerance in Bacteria"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Keynote Session: Biochemical Studies / Omics Approaches
Discussion Leaders: William Shafer (Emory University School of Medicine, USA) and Caroline Lee (National University of Singapore, Singapore)
9:00 am - 9:20 am
Hendrik van Veen (University of Cambridge, United Kingdom)
"Deciphering the Molecular Details of Substrate Transport and Energy Coupling in Bacterial Multidrug Efflux Pumps"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Arthur Neuberger (University of Cambridge, United Kingdom)
"Hoechst 33342 Is a Hidden 'Janus' Amongst Substrates for the Multidrug Efflux Pump LmrP"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Jennifer Reimche (Emory University School of Medicine, USA)
"Transcriptional Activation of Genes Encoding the MacAB Macrolide Efflux Pump by MisR in Neisseria gonorrhoeae "
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Paulo Juarez (University of Franche-Comté, France)
"Carbonyl Stress Induces the Efflux System MexEF-OprN in Pseudomonas aeruginosa via a Novel Transcriptional Regulator, CmrA"
10:20 am - 10:25 am
Discussion
10:25 am - 10:40 am
Onat Kadioglu (Johannes Gutenberg University of Mainz, Germany)
"Genomic and Transcriptomic Profiling of Resistant CEM/ADR-5000 and Sensitive CCRF-CEM Leukaemia Cells for Unravelling the Full Complexity of Multi-Factorial Multidrug Resistance"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development Panel
Discussion Leader: Karl Hassan (University of Leeds, United Kingdom)
1:30 pm - 2:30 pm
Panel Discussion
Career Development Panel
Toshihisa Ishikawa (NGO Personalized Medicine and Healthcare, Japan)
Caroline Lee (National University of Singapore, Singapore)
Olga Lomovskaya (The Medicines Company, USA)
William Shafer (Emory University School of Medicine, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes