Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Approaches in Understanding Efflux Pumps
Discussion Leader: Xin Chen (University of Washington, United States)
3:45 pm - 3:55 pm
Charlotte Guffick (University of Cambridge, United Kingdom)
"A Biosensor for Multi-modal Characterisation of an Essential ABC Transporter for Next-Generation Antibiotic Research"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Pauline Siasat (University of Birmingham, United Kingdom)
"Turning Off Efflux Pump Expression to Combat Antibiotic Resistance"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Vinay Barnabas (Indian Institute of Technology Bombay, India)
"Bounds on Efflux-Based Resistance"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Efflux Pumps: Structural-Functional Investigation and Exploring Inhibitors
Discussion Leader: Charlotte Guffick (University of Cambridge, United Kingdom)
7:30 pm - 7:40 pm
Logan Kavanaugh (Emory University, United States)
"Berberine dimers as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Narakorn Khunweeraphong (Medical University of Vienna, Austria)
"Mechanisms of Drug Transport and Recognition at the Binding Pockets of a Triple-Gate ABCG2"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Rushikesh Tambat (University of Oklahoma, United States)
"Broad-spectrum and AdeIJK Efflux Pump-Specific Inhibitors Revive Antibiotic Activity in Acinetobacter Baumannii"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Laura Danner (Medical College of Wisconsin, United States)
"Non-Nutritive Sweeteners Sucralose and Acesulfame Potassium are Competitive Inhibitors of Human P-glycoprotein (MDR1)"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Shalyn Brown (NIEHS, DTT, United States)
"Rapid Inhibition of P-glycoprotein Activity at the Blood-Brain Barrier by Erastin Requires iNOS"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Lea-Marie Nentwig (Heinrich-Heine-University Düsseldorf, Germany)
"Functional Analysis of the N-Terminal Extension of the ABC Transporter Pdr5 from S. Cerevsiae"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Marine Novelli (Aix-Marseille University, France)
"Screening of RND Efflux Pump Inhibitors in Gram-Negative Bacteria and Biochemical Proof of Concept"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Muhammad Ramiz Uddin (The University of Oklahoma, United States)
"Inhibition of The Dynamics of AcrA, The Periplasmic Component of AcrAB-TolC Efflux Pump"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Keynote Session: Efflux Pumps in Public Health
Discussion Leaders: Nghi Tran (Texas Tech University Health Sciences Center, United States) and Ednah Ooko (Kenya Medical Research Institute (KEMRI) - Wellcome Trust, Kenya)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:45 am
Kim Brouwer (University of North Carolina (UNC) Eshelman School of Pharmacy, United States)
"Hepatic Efflux Pumps in Human Health and Disease - Fundamental Knowledge for Precision Dosing"
9:45 am - 10:00 am
Discussion
10:00 am - 10:10 am
Lily Elizabeth Feldman (University of Colorado-Anschutz Medical Campus, United States)
"Prioritizing Mechanistic Targets in Chemo-Resistant Muscle-Invasive Bladder Cancer"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Valeria Jaramillo-Martinez (Texas Tech University Health Sciences Center, United States)
"Biochemical and Molecular Characterization of The Most-Common SLC13A5-Epilepsy Causing Missense-Mutations"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Xin Chen (University of Washington, United States)
"Maternal and Fetal Exposure to (-)-?9-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP)"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Heather Aitken (University of Queensland, Australia)
"Insights into (the lack of) ABCG2 substrate specificity"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building Collaborations and Career Development: The Roads after Graduation
Discussion Leaders: Lauren Aleksunes (Rutgers University, United States) and Hendrik van Veen (University of Cambridge, United Kingdom)
1:30 pm - 1:40 pm
Kim Brouwer (University of North Carolina (UNC) Eshelman School of Pharmacy, United States)
"Passion, Innovation, Persistence, and Strategic Focus: Hallmarks of Successful Early Career Researchers"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Otakuye Conroy-Ben (Arizona State University, United States)
"Career Guidance"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Klaas Pos (Goethe University Frankfurt, Germany)
"Being Geographically Flexible, Accepting Challenges, and The Importance of Mentors"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Helen Zgurskaya (University of Oklahoma, United States)
"The Multiverse of Bacterial Drug Efflux"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
