Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Understanding and Utilizing Multiscale Mechanical Phenomena
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"Mechanochromic Polymers Based on Supramolecular Motifs"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Designer Matrices to Study Mechanosignalling in Patient-Derived Cultures"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms of Synthetic Mechanophores
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Mechanoluminescent Polymers"
9:35 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Design and Reactivity of Ladderane-Family Mechanophores"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Facile Mechanophore Integration in Heterogenous Biologically Derived Materials via “Dip-Conjugation""
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Unlocking the Mechanochemical Secrets of Carbamoyloximes"
11:35 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Mechanophores as Kick-Starters for Reaction Cascades"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Towards Controlled Drug Delivery from Hydrogels Based on Ultrasound Induced Molecular Release"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Biological Mechanosensing
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Are Bacterial Adhesins Evolving to Cling More Tightly? A Computational Exploration of Mechanoactive Bond Mechanostability"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Quantitative Super-Resolution Imaging of Molecular Force in Cell Adhesion"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Force Filters in Inner Ear"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Visualising and Quantifying Mechanical Processes
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"A New Tool for Direct Quantitative Measurement of Mechanical Forces at the Cellular and Matrix Level"
9:35 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Super-Deformability of Induced Pluripotent Stem Cell Cysts"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Single-Cell Physical Phenotyping of Mechanically Dissociated Tissue Biopsies for Fast Diagnostic Assessment"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Cell or Organ: At Which Scale are Mechanical Forces Controlled in Plants?"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Advancing Nanobiomechanical Research: Large Tissue Area Mapping and Nano Scale Rheology via AFM"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"The Interplay of Mechanical Force and Electronic Structure Determines the Reaction Mechanism"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structure-Mechanics Relationships in Materials
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Developing Tools to Explore and Exploit In Situ Protein Unfolding During Network Formation"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Super-Recovery of Ultimate Strength in Double Network Hydrogels Through Scission-Induced Topological Remodeling of Polymer Networks"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Uncovering Sequence: Mechanical Function Relationships in Protein-Based Materials with Physically Informed Machine Learning"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanics in Health and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Spheroid Models to Study Cancer Cell Behaviors"
9:35 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Spatial Biomechanics Drives Breast Cancer Progression and Outcome"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Modeling of Recursive Cell-Matrix Feedback"
11:15 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Navigating Long Confinements Requires a Switch in Cell Morphology"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Mechanotransduction Pathways in Airway Epithelial Cells: Insights Into Asthma Pathogenesis"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Self-Healing and Self-Reporting Materials
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Ratiometric Force Imaging and Photoinduced Melting of Materials"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Mechano-Adaptive Tough and Fatigue Resistant 3D-Printable Polyrotaxane Hydrogels"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Using Bio-Inorganic Chemical Dynamics to Engineer Soft Material Mechanics and Beyond"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Tissue Development, Regeneration and Engineering
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Development, Regeneration, and Engineering. A Confinement Approach"
9:35 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Mechano-Transduction via Membrane Potential and Growth Control"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Modeling How Mechanical Forces Impact Shape and Morphology of 3D Epithelial Tissues"
11:15 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Stem Cell Dancing Enhances 3D Chondrogenesis via Early-Stage Cytoskeleton and Nuclear Mechanosensing"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Tunable Piezoelectric Biomaterials for Tissue Regeneration"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Multifunctional Biological and Bioinspired Materials
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Mechano-Adaptive Hydrogels with Metamaterial Strain Gates and Reaction-Diffusion Signaling"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Function and (Re)formation of Mechanoresponsive Quick-Release Biointerfaces in Mussels"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure