SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome by Justin Molloy / Introductory Comments by GRC Site Staff |
7:40 pm - 8:50 pm | STRUCTURAL BIOLOGY OF MOTORS AND TRACKS I |
| Discussion Leader: Anne Houdusse (Institut Curie, Paris) |
7:40 pm - 8:00 pm | Keiko Hirose (Institute for Cell Engineering, Ibaraki, Japan)
"Cryo-EM studies of microtubule motors" |
8:00 pm - 8:10 pm | Charles Sindelar (Lawrence Berkeley Natl Lab, Berkeley, CA)
"A common microtubule activation mechanism for plus- and minus-end directed kinesin motors" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Anne Houdusse (Institut Curie, Paris)
"A new myosin VI state reveals how actin triggers phosphate release" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:30 pm | OPENING KEYNOTE |
| Chair: Anne Houdusse (Institut Curie, Paris) |
8:50 pm - 9:20 pm | Lee Sweeney (University of Pennsylvania)
"Progress in unraveling the motor mechanism of myosin" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:45 am | STRUCTURAL BIOLOGY OF MOTORS AND TRACKS II |
| Discussion Leader: Anne Houdusse (Institut Curie, Paris) |
9:00 am - 9:20 am | David D. Thomas (University of Minnesota)
"Dynamics of the actomyosin interaction" |
9:20 am - 9:30 am | Chris Yengo (UNC Charlotte, Charlotte, NC)
"Structural dynamics of functional domains in myosin V examined with spectroscopic, kinetic, and computational methods" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Jared Cochran (Dartmouth College Hanover, NH)
"Structural and Mechanistic Analysis of the Drosophila Nod Kinesin during its Unique ATPase Cycle" |
9:50 am | Coffee Break / Group Photo |
10:30 am - 12:00 pm | KINETIC PATHWAYS AND REGULATION I |
| Discussion Leader: Steven Rosenfeld (Columbia Medical School, New York) |
10:30 am - 10:50 am | Stan Burgess (University of Leeds, UK)
"Dynein structure and power stroke" |
10:50 am - 11:10 am | Kazu Sutoh (University of Tokyo, Japan)
"Communication of multiple ATPase sites of the dynein motor domain" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Susan Gilbert (Rensselaer Polytechnic Institute, New York)
"Kinesin head-head coordination" |
11:40 am - 11:50 am | Sarah Rice (Northwestern, IL)
"Mechanism of Kinesin Regulation by its Tail" |
11:50 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 8:20 pm | KINETIC PATHWAYS AND REGULATION II |
| Discussion Leader: Steven Rosenfeld (Columbia Medical School, New York) |
7:30 pm - 7:50 pm | Steven Rosenfeld (Columbia Medical School, New York)
"How kinetics informs us about cell physiology - The story of CENP-E" |
7:50 pm - 8:00 pm | Enrique De La Cruz (Yale University, CT)
"ATP utilization and duplex rRNA unwinding by the DEAD-box protein, DbpA" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Mihaly Kovacs (Eotvos University, Hungary)
"Blebbistatin alters communication between functional regions of myosin" |
8:30 pm - 8:40 pm | Chris Berger (University of Vermont, VT)
"Coordination Between the Active Site and Actin-binding Cleft in Myosin: A Role for Flexibility of the Upper 50 kD Subdomain?" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:30 pm | EMERGENT PROPERTIES OF MOTOR SYSTEMS I |
| Discussion Leader: Peter Knight (University of Leeds, UK) |
8:50 pm - 9:10 pm | Peter Knight (University of Leeds, UK)
"Influences of myosin levers on motor function" |
9:10 pm - 9:20 pm | Ron Rock (University of Chicago, IL)
"Navigating the cytoskeleton with myosin X" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | EMERGENT PROPERTIES OF MOTOR SYSTEMS II |
| Discussion Leader: Peter Knight (University of Leeds, UK) |
9:00 am - 9:20 am | Jonathon Howard (Max-Planck, Dresden, Germany)
"Kinesin-8, a translocase and length-dependent depolymerase" |
9:20 am - 9:40 am | Kristen Verhey (University of Michigan)
"Road signs for kinesin motors" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Arne Gennerich (UCSF, CA)
"Force-dependent stepping of cytoplasmic dynein" |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Mike Ostap (University of Pennsylvania)
"Myosin I can act as a force sensor" |
10:50 am - 11:00 am | Mike Geeves (University of Kent, UK)
"Calcium regulation of mammalian myosin 1C" |
11:00 am - 11:10 am | Discussion |
11:10 am - 12:00 pm | THEORETICAL FRAMEWORKS AND MOTOR MECHANISM I |
| Discussion Leader: Jonathon Howard (Max-Planck, Dresden, Germany) |
11:10 am - 11:30 am | Frank Julicher (Max-Planck, Dresden, Germany)
"Oscillating motor systems" |
11:30 am - 11:40 am | Pascal Martin (Institut Curie, Paris France)
"Spontaneous oscillations and negative friction powered by a minimal acto-myosin system" |
11:40 am - 11:50 am | Michael E. Fisher (University of Maryland, MD)
"What superstall and assisting loads may teach us?" |
11:50 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | THEORETICAL FRAMEWORKS AND MOTOR MECHANISM II |
| Discussion Leader: Jonathon Howard (Max-Planck, Dresden, Germany) |
7:30 pm - 7:50 pm | Sean Sun (John Hopkins University, Baltimore)
"A general framework for modeling dimeric processive motors" |
7:50 pm - 8:00 pm | Andrej Vilfan (Stefan Institute, Ljubljana, Slovenia)
"Models of myosin V" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Holly Goodson (University of Notre Dame, Indiana)
"Influence of physical constraints on microtubule dynamics" |
8:30 pm - 8:50 pm | Gabriella Piazzesi (University of Florence, Italy)
"Myosin structural dynamics and muscle function" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Malcolm Irving (King's College London, UK)
"Is the myosin II light-chain domain a rigid lever arm?" |
9:10 pm - 9:20 pm | Gerald Offer (University Bristol, UK) & Ed Taylor (Northwestern, IL)
"Recent controversy in low-angle x-ray scattering data from muscle fibers" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | POWER-STROKES AND RATCHETS |
| Discussion Leader: Steven Block (Stanford University, California) |
9:00 am - 9:20 am | Toshio Yanagida (Osaka University, Japan)
"Thermal ratchet and its application to artificial muscle" |
9:20 am - 9:40 am | Hideo Higuchi (Tokyo University, Sendai, Japan)
"Step size of dynein is determined by distances of a power stroke and fluctuation" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Kathy Trybus (University of Vermont, VT)
"Myosin V and Kinesin act as tethers to enhance each others' processivity" |
10:00 am | Coffee Break |
10:30 am - 12:10 pm | MOTORS THAT DRIVE INFECTION AND DISEASE I |
| Discussion Leader: James Sellers (NHLBI - NIH) |
10:30 am - 10:50 am | Marie-France Carlier (LEBS, CNRS, France)
"How reconstituted motility assays bring insight into actin-based motile and morphogenetic processes" |
10:50 am - 11:00 am | Inna Belyantsava (NIDCD - NIH)
"New insight into gamma-actin function in inner ear hair cell stereocilia" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:20 am | Yuichiro Maeda (Nagoya University Japan)
"The nature of the G- to F-actin transition" |
11:20 am - 11:30 am | Kenneth Holmes (MPI Heidelberg, Germany)
"F-actin revisited" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | John Hammer (NHLBI - NIH)
"Myosin V and memory" |
12:00 pm - 12:10 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 8:10 pm | MOTORS THAT DRIVE INFECTION AND DISEASE II |
| Discussion Leader: James Sellers (NHLBI - NIH) |
7:30 pm - 7:50 pm | James Sellers (NHLBI - NIH)
"Heads to tails: how some myosins auto regulate" |
7:50 pm - 8:00 pm | Lois Weisman (University of Michigan)
"Direct regulation of the vacuole-specific myosin V receptor by the cyclin-dependent kinase, Cdk1" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 9:00 pm | ALEXANDER CRUICKSHANK LECTURE |
| Introduction: Justin E. Molloy (MRC NIMR, UK) |
8:10 pm - 8:50 pm | Steven Block (Stanford University, California)
"Breaking the nanometer barrier: Biophysics, one molecule at a time" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm | Posters / Social Gathering |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:00 am | DETERMINANTS OF PROCESSIVITY AND DIRECTIONALITY |
| Discussion Leader: Claudia Veigel (MRC NIMR, UK) |
9:00 am - 9:20 am | Claudia Veigel (MRC NIMR, UK)
"Myosin kinetics under load" |
9:20 am - 9:30 am | Masahide Kikkawa (Kyoto University, Japan)
"What are the structural effects of load applied to motors?" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Sivaraj (Shiv) Sivaramakrishnan (Stanford University, California)
"Unusual protein structural elements involving myosin motors" |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Samara Reck-Peterson (Harvard Medical School, Massachusetts)
"Regulation of cytoplasmic dynein processivity" |
10:50 am - 11:10 am | Christoph Schmidt (Georg-August University, Göttingen, Germany)
"Processive or diffusive: regulated motility of the mitotic Eg5 kinesin" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Yale Goldman (University of Pennsylvania, PA)
"Navigation by myosin isoforms and dynein" |
11:30 am - 11:40 am | Takeshi Satamoto (NHLBI - NIH)
"Direct observation of the mechanochemical coupling in myosin-V during processive movement" |
11:40 am - 11:50 am | Giovanni Cappello (Institut Curie, Paris)
"Single Myosin V Beyond the Membrane" |
11:50 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:20 pm - 7:50 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:50 pm - 8:50 pm | SUMMARY AND GENERAL |
7:50 pm - 8:20 pm | David D. Thomas (University of Minnesota)
"Summary and General" |
8:20 pm - 8:30 pm | Short Presentations |
8:30 pm - 8:40 pm | Short Presentations |
8:40 pm - 8:50 pm | Short Presentations |
8:50 pm - 9:30 pm | MATSUBARA LECTURE |
| Chair: Yale E. Goldman (University of Pennsylvania) |
8:50 pm - 9:20 pm | David M. Warshaw (University of Vermont)
"General Motors: Stepping into the future" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |