| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Structural Biology of Molecular Motors |
| Chair: Kathy Trybus, Poster/Discussion Chairs: Ken Holmes, Dorit Hanein |
| 7:30 | Welcome: David Warshaw and GRC Staff |
| 7:45 | K. Trybus
The IQ motifs of Myosin V |
| 8:00 | J. Kull
Crystal structure of an unconventional class-I myosin |
| 8:15 | E. Sablin
Nucleotide switches in molecular motors |
| 8:40 | J. Brown
Deciphering the design of the tropomyosin molecule |
| 9:00 | K. Holmes, D. Hanein Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Muscle Myosin: Functional Boundries |
| Chair Bernhard Brenner; Poster/Discussion Chairs Justin Molloy, Bernhard Brenner |
| 9:00 | B. Brenner
Introduction |
| 9:25 | T. Yanagida
What determines the myosin stepsize ? |
| 9:50 | J. Baker
Single molecule mechanochemistry of myosin motors |
| 10:15 | J. Bordas
The structure of the actomyosin cross-bridge studied by interference x-ray diffraction. |
| 10:40 | Coffee break and photograph |
| 11:15 | J. Molloy, B. Brenner Discussion
Discussion Participants: H. Huxley, M. Irving |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Reception and Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Structural Dynamics of Myosin During Crossbridge Cycle |
| Roger Cooke, Chair; David Thomas, Poster/Discussion Chair |
| 7:30 | R. Cooke
Introduction |
| 7:35 | C. Berger
Intrinsic probes of domain movements in smooth muscle myosin |
| 8:00 | Y. Goldman
Single-Molecule Mechanics and Structural Dynamics of Actomyosin |
| 8:25 | D. Thomas
Spectroscopic probes of myosin structural dynamics
Discussion: |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Myosin Function Modulation by Thin Filament Regulation |
| John Solaro, Chair; Sarah Hitchcock-DeGregori, Poster/Discussion Chair |
| 9:05 | S. Takeda (Matsubara Honorary Lecture)
Molecular Switches in Troponin Complex |
| 9:30 | L. Tobacman
Myosin Inhibition by the Troponin Tail Domain and Myosin Activation by the Mid-Section of Tropomyosin. |
| 9:55 | J. Potter
The Role of TnT Isoforms in the Regulation of Muscle Contraction |
| 10:20 | W. Lehman
Thin Filament Structure and Regulation by Troponin-Tropomyosin. |
| 10:45 | Coffee Break |
| 11:15 | E. Reisler
Thin Filament Regulation: The View from Actin |
| 11:40 | S. Hitchcock-DeGregori Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Myopathies: Structural Mutations and Functional Implications |
| Jeff Robbins, Chair; Leslie Leinwand, Neal Epstein, Poster/Discussion Chairs |
| 7:30 | J. Robbins
Introduction |
| 7:35 | L. Leinwand
Signaling Pathways in Cardiac Hypertrophy |
| 8:00 | C. Redwood
HCM Mutations and Functional Changes in Thin Filament Regulation |
| 8:25 | N. Epstein
Stretch Activation and the Role it Plays in the Heart |
| 8:50 | L. Leinwand, N. Epstein Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Biology of Unconventional Myosins |
| Meg Titus, Chair; Richard Cheney, Discussion/Poster Chair |
| 9:00 | M. Titus
Myosin VII, adhesion, and the role of tail domains in localization and function. |
| 9:25 | P. Gillespie
A chemical-genetic approach to unravel myosin function: myosin-1c
mediates adaptation in sensory hair cells |
| 9:50 | J. Kendrick-Jones
Probing the roles of myosin VI in vesicle transport and membrane dynamics |
| 10:15 | D. Soldati
Toxoplasma gondii myosin A: a fast motor of the class XIV which powers an unusual form of cell motility. |
| 10:40 | Coffee Break |
| 11:10 | Richard Cheney Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Unconventional Myosins |
| Lee Sweeney, Chair; Mike Ostap, Poster/Discussion Chair |
| 7:30 | L. Sweeney
Overview: Unusual structural and functional properties of the unconventional myosins |
| 7:55 | M. Ikebe
Motor function of mammalian unconventional myosin |
| 8:20 | M. Ostap
Rating the Myosin-Is |
| 8:45 | Mike Ostap Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Comparative Molecular Motor Function |
| Jim Sellers, Chair; E. De La Cruz Poster/Discussion Chair |
| 9:00 | J. Sellers
Introduction |
| 9:05 | K. Oiwa
Molecular organization of an axonemal dynein studied by SAXS analysis and electron microscopy. |
| 9:30 | K. Kinosita
Rotary mechanism of F1-ATPase |
| 9:55 | M. Tomishige
"Novel regulatory mechanism for the processive movement of a class of monomeric kinesin motor". |
| 10:20 | S. Block
All that moves is not myosin |
| 10:45 | Coffee break |
| 11:10 | E. De La Cruz Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Comparative Muscle Myosin Function |
| Christine Cremo, Chair; Robert Adelstein, Poster/Discussion Chair |
| 7:30 | C. Cremo
How does phosphorylation alter the structure of smooth muscle myosin? |
| 7:55 | S. Bernstein San Diego State University
Isoform-specific domains of myosin and phosphorylation of paramyosin regulate skeletal muscle function |
| 8:20 | T. Butler
The Myosin Crossbridge Cycle and Its Control by Twitchin Phosphorylation in
Catch Muscle |
| 8:45 | Robert Adelstein Discussion |
| 9:30 | Dance Party |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
