| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Welcome and Keynote Lecture |
| Jim Spudich, Stanford University |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of Myosin Motors and Muscle Contraction |
| Discussion Leader: Kathy Trybus, University of Vermont
"Regulation and processivity of myosin V" |
| Roger Craig, Univ. of Mass., Worchester, MA
"Atomic model of the "OFF" state of a myosin filament determined by cryo-EM" |
| Y. Maeda, RIKEN Harima Institute at Spring-8, Mikazuki, Sayo, Hyogo, Japan
"Tropomyosin crystal structure and structural changes of the regulatory proteins upon Ca2+-binding" |
| Maia Vinogradova, UCSF, San Francisco, CA
"Modeling troponin crystal structures on thin filaments" |
| Chosen Discussants |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Myosin Movement beyond the Lever Arm |
| Discussion Leader: H. Lee Sweeney, University of Pennsylvania, Philadelphia
"Movements of myosin VI" |
| Toshio Yanagida, Biomotron Project, ERATO, Osaka, Japan
Matsubara Lecture: "A model for the muscle contraction mechanism based on actin filament rotation" |
| Peter Knight, University of Leeds, Leeds, UK
"The question of dimerization among unconventional myosins" |
| Chosen Discussants |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Structural Mechanisms of Force/Movement Generation |
| Discussion Leader: Yale Goldman, University of Pennsylvania, Philadelphia
"Promotion of the Power Stroke and Product Release by Binding of the Myosin Products Complex to Actin" |
| Anne Houdusse, Insitut Curie, Paris, France
"The Motor Mechanism of Myosin V" |
| Ken Holmes, Max Planck Insitute for Medical Research, Heidelberg, Germany
"Switch1, Switch 2 and the Power Stroke" |
| Dave Thomas, University of Minnesota, Minneapolis, MN
"Structural Dynamics of S1 Bound to Actin Probed with a Bifunctional Spin Label" |
| Clive Bagshaw, University of Leicester, Leicester, UK
"Motions of myosin II Switch 1 and Switch 2 in Solution" |
| Chosen Discussants |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Myosin Force and Movement Generation in Muscle |
| Discussion Leader: Malcolm Irving, Kings College, London, UK
"Correlating structural, mechanical and biochemical states of myosin heads in muscle fibers" |
| Theresia Kraft, Hannover Medical School, Hannover, Germany
"Initiation of the power stroke in muscle: Insights from two ADP-phosphate analog states with AlF4" |
| Vincenzo Lombardi, University of Florence, Florence, Italy
"The structural basis of the force-velocity relation" |
| Marco Linari, University of Florence, Florence, Italy
"Effect of inorganic phosphate on force and shortening in skinned muscle fibers" |
| Chosen Discussants |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Microtubular Motor Function |
| Discussion Leader: K. Oiwa, Chair, University of Kobe, Kobe, Japan
"Structures and mechanical properties of single-headed and double-headed axonemal dyneins" |
| Steve Gross, UC Irvine
"Single-molecule experiments on cytoplasmic dynein: what do they tell us about its mechano-chemical cycle?" |
| Kazuo Sutoh, University of Tokyo, Japan
"The molecular mechanism of force generation by cytoplasmic dynein" |
| Christoph Schmidt, Vrije University at Amsterdam
"Four heads are better than two: Microscopic mechanism of the mitotic kinesin Eg5" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Influence of load on the actomyosin cycle of muscle |
| Discussion Leader: Michael Ferenczi, Mill Hill, UK
"Influence of load on the actomyosin cycle of muscle" |
| Henry Shuman, University of Pennsylvania, Philadelphia, PA
"Force Generation in Single Conventional Actomyosin Complexes Under High Dynamic Load" |
| K.W. Ranatunga, University of Bristol, Bristol, UK
"Load dependence of force generation" |
| Kevin Burton, The Randall Centre, King's College London, London, UK
"Crossbridge strain-dependent effects in force development in muscle" |
| Michael Geeves, University of Kent, Canterbury, UK
"The influence of load on actin and nucleotide binding to one and two headed myosins" |
| Chosen Discussants |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Influence of load on processive motors |
| Discussion Leader: Claudia Veigel, MRC Mill Hill, England
"Load dependent kinetics of myosin motors" |
| Neil Kad, University of Vermont, Burlington, VT
"Studies of myosin II and V: unifying concepts of strain sensitivity" |
| Steve Rosenfeld, Columbia University, NY, NY
"What kinesin can teach us about myosin, and vice versa" |
| Nicholas R. Guydosh, Stanford University, Palo Alto, CA
"What backstepping induced by ATP analogs tells us about kinesin head coordination" |
| Nick Carter, Marie Curie Research Institute, Oxted, Surrey
"Forward and backsteps of kinesin" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | 51 years of sliding filaments |
| Closing Speaker: Hugh Huxley, Brandeis University, Waltham, MA
"Progress on long-standing problems in muscle contraction: Origins, evidence and techniques" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
