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Muscle: Excitation-Contraction Coupling

Gordon Research Conference

June 8 - 13, 1997
Chair
Vice Chair
Colby-Sawyer College
541 Main Street
New London, New Hampshire, United States
 Venue and Travel Information

Conference Program

Sunday, June 8, 1997

I - STRUCTURE AND ASSEMBLAGE OF E-C COUPLING COMPONENTS

B. Block and A. Jorgensen, Discussion Leaders
  1. Annelise Jorgensen (Univ. Toronto) - Introduction

  2. Larry Jones (Indiana Univ., Indianapolis) - "Junctin and other triadic proteins"

  3. Clara Franzini-Armstrong (Univ. Pennsylvania, Philadelphia) - "Structure-function relationships in triadic junctions."

  4. Barbara Block (Stanford Univ.) - "Evolutionary considerations in the study of structure."

  5. Panel on DHP receptor mutants. - Jeanne Powell (Smith College, Northhampton), Bernhard Flucher (Univ. Innsbruck), Ronald Gregg (Univ. Louisville).

Monday, June 9, 1997

II - ION PERMEABILITY IN NORMAL AND DISEASED MUSCLE

Discussion leaders: S. Cannon and F. Lehmann-Horn
  1. Frank Lehmann-Horn (Univ. Ulm) - Introduction

  2. Christoph Fahlke (Vanderbilt U., Nashville) - "Cl channel defects: myotonia congenita"

  3. Stephen Cannon (Harvard Univ., Boston) - "Skeletal muscle Na channel defects: HyperPP / PMC / PAM"

  4. Michael Sanguinetti (Univ. Utah, Salt Lake City) - "Heart muscle potassium channel defects: Long QT syndromes"

  5. Annegret Herrmann-Frank (Univ. Ulm) - "Ca2+ release channel defects of the SR"

  6. Jiefei Tong (Univ. Toronto) - "Ca2+ release channel defects of the SR"

III - Ca HOMEOSTASIS, PUMPS AND FATIGUE

Discussion leader: E. Murphy
  1. Pompeo Volpe (Univ. Padova) - "Ca2+ homeostasis in muscle"

  2. Elizabeth Murphy (NIEHS, NIH) - "Measurement and Regulation of ionized SR Ca2+"

  3. Robert Fitts (Marquette U., Milwaukee) - " Alterations in E-C Coupling with Muscle Fatigue"

  4. Hakan Westerblad (Karolinska Inst., Stockholm) - "The role of low ATP in skeletal muscle fatigue"

  5. Ruth Altschuld (Ohio State Univ., Columbus) - "Sarcoplasmic reticulum in heart failure: central player or bystander"

Tuesday, June 10, 1997

IV - VOLTAGE CONTROL OF CHANNEL GATING

Discussion leader: K. Beam
  1. Junichi Nakai (NIPS, Okazaki) - "Calcium channels and excitation-contraction coupling"

  2. Julio Vergara (U. California, Los Angeles) - "Fast kinetic resolution of skeletal muscle charge movement and its coupling to SR Ca2+ release"

  3. Lutz Birnbaumer (U. California, Los Angeles) - "Regulation of the voltage-gated calcium channel"

  4. Kurt Beam (Colorado State U., Fort Collins) - "Structure-function studies of calcium channels"

  5. Stephen Jones (CWRU, Cleveland) - "voltage-operate gating of calcium channels"

  6. Roberto Coronado (Univ. Wisconsin, Madison) - "electrophysiology of beta-null muscle cells"

  7. Paul Allen (Brigham & Women's Hospital, Boston) - "morphology and biochemistry of RyR1-null muscle cells"

V - MOLECULAR STUDIES OF RYANODINE RECEPTORS

Discussion leaders: S. Hamilton and F. Zorzato
  1. Francesco Zorzato (Univ. Ferrara) - Introduction

  2. Michel Ronjat (CNRS, Grenoble) - "Regulation of skeletal ryanodine receptor: intra and inter molecular interactions."

  3. Yasuo Ogawa (Juntendo Univ., Tokyo) - "Properties of RYR3 in rabbit brain and skeletal muscle."

  4. Isaac Pessah (U. California, Davis) - "Relationship between ryanodine-sensitive and -insensitive Ca2+ efflux pathways of skeletal SR and a transgenic muscle cell line. Possible role of FKBP12."

  5. Terry Wagenknecht (SUNY, Albany) - "Structural Studies of Ca2+ Release Channels"

  6. Susan L. Hamilton (Baylor Coll. Med., Houston) - Summary

Wednesday, June 11, 1997

VI - SR Ca CHANNEL MODULATION IN CELLS AND MODEL SYSTEMS

Discussion leaders: A. Marks, G. Meissner
  1. Michael Fill (Loyola U., Chicago) - "Ryanodine receptor Ca2+ regulation: Activation, deactivation and adaptation."

  2. Sidney Fleischer (Vanderbilt U., Nashville) - "Modulation of the ryanodine receptor"

  3. Jianjie Ma (CWRU, Cleveland) - "Functional Ca2+ release channel formed by the C-terminal portion of ryanodine receptor"

  4. Ashutosh Tripathy (UNC, Chapel Hill) - "Regulation of Ca2+ release channel by cytosolic and luminal Ca2+."

  5. Alan Williams (IMperial College, London) - "The interaction of ryania alkaloids with single SR Ca2+ release channels."

VII - PHYSIOLOGICAL CONTROL OF Ca2+ RELEASE

Discussion leaders: S. Gyorke, G. Lamb
  1. Stephen Hollingworth (Univ. Pennsylvania, Philadelphia) - "Calcium transients and SR calcium release in fish, frog and mammal."

  2. Graham Lamb (La Trobe U., Victoria) - "Control and modulation of Ca2+ release in skinned skeletal fibers."

  3. Sandor Gyorke (Texas Tech., Lubbock) - "Luminal calcium control of calcium release in the heart."

  4. Roque El Hayek (Boston Biomed. Res. Inst.) - "Peptide probe study of signalling in E-C coupling"

  5. Norio Suda (Colorado State U., Fort Collins) - "Voltage-control of Ca2+-induced Ca2+ release in skeletal myotubes."

Thursday, June 12, 1997

VIII - ELEMENTARY EVENTS OF Ca2+ RELEASE

Discussion leaders: M. F. Schneider and W. G. Wier
  1. Martin Schneider (Univ. Maryland, Baltimore) - "Introduction to skeletal sparks and ligand gating of skeletal sparks"

  2. Michael Klein (Univ. Maryland, Baltimore) - "Voltage controlled skeletal sparks"

  3. Natalia Shirokova (Rush Univ., Chicago) - "Sparks and smaller events in skeletal fibers"

  4. Gil Wier (Univ. Maryland, Baltimore) - "Introduction to cardiac sparks and sparks and sub-sparks in cardiac myocytes"

  5. Ernst Niggli (Univ. Bern) - "Artificial cardiac calcium sparks by 2 photon photolysis"

  6. Lothar Blatter (Loyola Univ., Chicago) - "Ca2+ release flux in cardiac sparks"

  7. Luis F. Santana (Univ. Maryland, Baltimore) - "Local Calcium Signals (Ca2+ sparks) in Genetically Engineered Hearts"

IX - INTRACELLULAR RELEASE CHANNELS. DISTRIBUTION AND DIVERSITY

Discussion leaders: M. Iino and J. Sutko
  1. Masamitsu Iino (Univ. Tokyo) - "Introduction, Subtype Specificity in Intracellular Calcium Release Channels."

  2. Vincenzo Sorrentino (Inst. San Raffaele, Milano) - "Requirement of the Ryanodine Receptor Type 3 for Efficient Contraction in Neonatal Skeletal Muscles."

  3. Gregory Mignery (Loyola Univ., Chicago) - "Molecular and Functional Diversity Among IP3 Receptors."

  4. Andrew Thomas (Jefferson Univ., Phgiladelphia) - "Diversity of Hepatic Calcium Release Channels and Mechanisms."

  5. Enrique Jaimovich (Univ. Chile, Santiago) - "Nuclear IP3 Receptors and Associated Calcium Signals in Skeletal Muscle."

  6. John Sutko (Univ. Nevada, Reno) - Summary

Conference Links

Conference History
Additional Fee Info

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