Sunday, June 8, 1997
I - STRUCTURE AND ASSEMBLAGE OF E-C COUPLING COMPONENTS
B. Block and A. Jorgensen, Discussion Leaders
- Annelise Jorgensen (Univ. Toronto) - Introduction
- Larry Jones (Indiana Univ., Indianapolis) - "Junctin and other triadic proteins"
- Clara Franzini-Armstrong (Univ. Pennsylvania, Philadelphia) - "Structure-function relationships in triadic junctions."
- Barbara Block (Stanford Univ.) - "Evolutionary considerations in the study of structure."
- Panel on DHP receptor mutants. - Jeanne Powell (Smith College, Northhampton), Bernhard Flucher (Univ. Innsbruck), Ronald Gregg (Univ. Louisville).
Monday, June 9, 1997
II - ION PERMEABILITY IN NORMAL AND DISEASED MUSCLE
Discussion leaders: S. Cannon and F. Lehmann-Horn
- Frank Lehmann-Horn (Univ. Ulm) - Introduction
- Christoph Fahlke (Vanderbilt U., Nashville) - "Cl channel defects: myotonia congenita"
- Stephen Cannon (Harvard Univ., Boston) - "Skeletal muscle Na channel defects: HyperPP / PMC / PAM"
- Michael Sanguinetti (Univ. Utah, Salt Lake City) - "Heart muscle potassium channel defects: Long QT syndromes"
- Annegret Herrmann-Frank (Univ. Ulm) - "Ca2+ release channel defects of the SR"
- Jiefei Tong (Univ. Toronto) - "Ca2+ release channel defects of the SR"
III - Ca HOMEOSTASIS, PUMPS AND FATIGUE
Discussion leader: E. Murphy
- Pompeo Volpe (Univ. Padova) - "Ca2+ homeostasis in muscle"
- Elizabeth Murphy (NIEHS, NIH) - "Measurement and Regulation of ionized SR Ca2+"
- Robert Fitts (Marquette U., Milwaukee) - " Alterations in E-C Coupling with Muscle Fatigue"
- Hakan Westerblad (Karolinska Inst., Stockholm) - "The role of low ATP in skeletal muscle fatigue"
- Ruth Altschuld (Ohio State Univ., Columbus) - "Sarcoplasmic reticulum in heart failure: central player or bystander"
Tuesday, June 10, 1997
IV - VOLTAGE CONTROL OF CHANNEL GATING
Discussion leader: K. Beam
- Junichi Nakai (NIPS, Okazaki) - "Calcium channels and excitation-contraction coupling"
- Julio Vergara (U. California, Los Angeles) - "Fast kinetic resolution of skeletal muscle charge movement and its coupling to SR Ca2+ release"
- Lutz Birnbaumer (U. California, Los Angeles) - "Regulation of the voltage-gated calcium channel"
- Kurt Beam (Colorado State U., Fort Collins) - "Structure-function studies of calcium channels"
- Stephen Jones (CWRU, Cleveland) - "voltage-operate gating of calcium channels"
- Roberto Coronado (Univ. Wisconsin, Madison) - "electrophysiology of beta-null muscle cells"
- Paul Allen (Brigham & Women's Hospital, Boston) - "morphology and biochemistry of RyR1-null muscle cells"
V - MOLECULAR STUDIES OF RYANODINE RECEPTORS
Discussion leaders: S. Hamilton and F. Zorzato
- Francesco Zorzato (Univ. Ferrara) - Introduction
- Michel Ronjat (CNRS, Grenoble) - "Regulation of skeletal ryanodine receptor: intra and inter molecular interactions."
- Yasuo Ogawa (Juntendo Univ., Tokyo) - "Properties of RYR3 in rabbit brain and skeletal muscle."
- Isaac Pessah (U. California, Davis) - "Relationship between ryanodine-sensitive and -insensitive Ca2+ efflux pathways of skeletal SR and a transgenic muscle cell line. Possible role of FKBP12."
- Terry Wagenknecht (SUNY, Albany) - "Structural Studies of Ca2+ Release Channels"
- Susan L. Hamilton (Baylor Coll. Med., Houston) - Summary
Wednesday, June 11, 1997
VI - SR Ca CHANNEL MODULATION IN CELLS AND MODEL SYSTEMS
Discussion leaders: A. Marks, G. Meissner
- Michael Fill (Loyola U., Chicago) - "Ryanodine receptor Ca2+ regulation: Activation, deactivation and adaptation."
- Sidney Fleischer (Vanderbilt U., Nashville) - "Modulation of the ryanodine receptor"
- Jianjie Ma (CWRU, Cleveland) - "Functional Ca2+ release channel formed by the C-terminal portion of ryanodine receptor"
- Ashutosh Tripathy (UNC, Chapel Hill) - "Regulation of Ca2+ release channel by cytosolic and luminal Ca2+."
- Alan Williams (IMperial College, London) - "The interaction of ryania alkaloids with single SR Ca2+ release channels."
VII - PHYSIOLOGICAL CONTROL OF Ca2+ RELEASE
Discussion leaders: S. Gyorke, G. Lamb
- Stephen Hollingworth (Univ. Pennsylvania, Philadelphia) - "Calcium transients and SR calcium release in fish, frog and mammal."
- Graham Lamb (La Trobe U., Victoria) - "Control and modulation of Ca2+ release in skinned skeletal fibers."
- Sandor Gyorke (Texas Tech., Lubbock) - "Luminal calcium control of calcium release in the heart."
- Roque El Hayek (Boston Biomed. Res. Inst.) - "Peptide probe study of signalling in E-C coupling"
- Norio Suda (Colorado State U., Fort Collins) - "Voltage-control of Ca2+-induced Ca2+ release in skeletal myotubes."
Thursday, June 12, 1997
VIII - ELEMENTARY EVENTS OF Ca2+ RELEASE
Discussion leaders: M. F. Schneider and W. G. Wier
- Martin Schneider (Univ. Maryland, Baltimore) - "Introduction to skeletal sparks and ligand gating of skeletal sparks"
- Michael Klein (Univ. Maryland, Baltimore) - "Voltage controlled skeletal sparks"
- Natalia Shirokova (Rush Univ., Chicago) - "Sparks and smaller events in skeletal fibers"
- Gil Wier (Univ. Maryland, Baltimore) - "Introduction to cardiac sparks and sparks and sub-sparks in cardiac myocytes"
- Ernst Niggli (Univ. Bern) - "Artificial cardiac calcium sparks by 2 photon photolysis"
- Lothar Blatter (Loyola Univ., Chicago) - "Ca2+ release flux in cardiac sparks"
- Luis F. Santana (Univ. Maryland, Baltimore) - "Local Calcium Signals (Ca2+ sparks) in Genetically Engineered Hearts"
IX - INTRACELLULAR RELEASE CHANNELS. DISTRIBUTION AND DIVERSITY
Discussion leaders: M. Iino and J. Sutko
- Masamitsu Iino (Univ. Tokyo) - "Introduction, Subtype Specificity in Intracellular Calcium Release Channels."
- Vincenzo Sorrentino (Inst. San Raffaele, Milano) - "Requirement of the Ryanodine Receptor Type 3 for Efficient Contraction in Neonatal Skeletal Muscles."
- Gregory Mignery (Loyola Univ., Chicago) - "Molecular and Functional Diversity Among IP3 Receptors."
- Andrew Thomas (Jefferson Univ., Phgiladelphia) - "Diversity of Hepatic Calcium Release Channels and Mechanisms."
- Enrique Jaimovich (Univ. Chile, Santiago) - "Nuclear IP3 Receptors and Associated Calcium Signals in Skeletal Muscle."
- John Sutko (Univ. Nevada, Reno) - Summary
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