Find a Conference

Alert - GRC systems are offline for approximately one week. For more information, please click here.

Muscle: Excitation-Contraction Coupling

Gordon Research Conference

June 11 - 16, 2000
Chair David H. Maclennan
Vice Chair Martin F. Schneider
Colby-Sawyer College
541 Main Street
New London, New Hampshire, United States
 Venue and Travel Information

Conference Program

Sunday, June 11, 2000

Evening Session

I. MOLECULAR STRUCTURE OF E-C COUPLING COMPONENTS

Leaders:
David Stokes
Terry Wagenknecht

Time Speaker Topic
19:45-20:00 Terry Wagenknecht Introduction to the structural basis of e-c coupling.
20:00-20:30 Eduardo Perozo Molecular basis of proton-dependent activation gating in KcsA.
20:30-21:00 Angela Dulhunty Structure of an RyR binding domain on the skeletal DHPR II-III loop: consequences for activation or inhibition of RyR.
21:00-21:30 Wah Chiu Electron cryomicroscopy of skeletal muscle Ca2+ release channels in different states.
21:30-22:00 ChulHee Kang Structure of calsequestrin: implications for calcium regulation.
22:00-22:30 David Stokes Structure and dynamics of the Ca2+ ATPase by electron microscopy.

Monday, June 12, 2000

Morning Session

II. GENETIC DISEASE RESULTING FROM DEFECTS IN E-C COUPLING PROTEINS

Leaders:
Frank Lehmann-Horn
Charles Louis

Time Speaker Topic
9:00-9:15 Frank Lehmann-Horn News and views in channelopathies.
9:15-9:45 Karin Jurkat-Rott A second gene for hypokalemic periodic paralysis.
9:45-10:15 Tommie McCarthy Malignant hyperthermia susceptibility and central core disease: what causes the difference.
10:15-10:45 Coffee break and group picture.
10:45-11:15 Jacques Veerkamp Alterations in native and cultured muscle of Brody disease patients.
11:15-11:30 David MacLennan Molecular genetics of Brody disease.
11:30-12:00 Steve Goldstein Channels involved in long QT syndrome and ventricular fibrillation.
12:00-12:30 Poster highlights.

Evening Session

III. STRUCTURE-FUNCTION ANALYSIS OF RYANODINE RECEPTORS

Leaders:
Jianje Ma
Wayne Chen

Time Speaker Topic
19:00-19:15 Jianjie Ma Limits and difficulties in the functional expression of ryanodine receptors in heterologous cells
19:15-19:45 GuoGuang Du The use of chimera formation and site-directed mutagenesis to analyze structure/function relationships in the ryanodine receptor.
19:45-20:15 Manjunatha Bhat Membrane topology and localization of ryanodine receptor calcium release channel.
20:15-20:45 Gerhard Meissner Probing the ion conducting pore of the Ca2+ release channel.
20:45-21:15 Gregory Mignery InsP3 receptor structure and function: "Pore Progress".
21:15-21:45 Wayne Chen Isoform-specific formation of heteromeric ryanodine receptor Ca2+ release channels.
21:45-22:15 Poster highlights.

Tuesday, June 13, 2000

Morning Session

IV. INTERACTIONS BETWEEN RYANODINE RECEPTORS AND alpha1-DIHYDROPYRIDINE RECEPTORS

Leaders:
Paul Allen
Clara Franzini-Armstrong

Time Speaker Topic
09:00-09:30 Clara Franzini-Armstrong DHPR-RyR: spatial relationships.
09:30-10:00 Kurt Beam Bi-directional signalling between DHPRs and RyRs.
10:00-10:30 Paul Allen EC-Coupling, orthograde and retrograde signalling through RyR1.
10:30-11:00 coffee break
11:00-11:30 Noriaki Ikemoto Peptide probe study of the signal transmission mechanism.
11:30-12:00 Hector Valdivia Activation of ryanodine receptors by Imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor.
12:00-12:30 Bernhard Flucher Molecular domains involved in targeting and modulation of the skeletal muscle DHP-Receptor.

Evening Session

V. MODULATION OF RYANODINE RECEPTOR FUNCTION BY ACCESSORY PROTEINS AND BY PROTEIN MODIFICATION

Leaders:
Susan Hamilton
Andy Marks

Time Speaker Topic
19:30-20:00 Andy Marks The ryanodine receptor as a macromolecular complex.
20:00-20:30 Sidney Fleischer Ryanodine receptors and FK-Binding Proteins: Isoforms, association and function.
20:30-21:00 Susan Hamilton Functional domains of RyR1.
21:00-21:30 Charles Louis Isoform-specific regulation of ryanodine receptors by calmodulin and dantrolene.
21:30-22:00 Francesco Zorzato Molecular and functional characterization of junctional sarcoplasmic reticulm proteins.
22:00-22:30 Meredith Bond A-kinase anchoring protein targeting of PKA to junctional sarcoplasmic reticulum in cardiac muscle.

Wednesday, June 14, 2000

Morning Session

VI. MODULATION OF RYANODINE RECEPTOR FUNCTION BY TRANSMEMBRANE GRADIENTS AND PHARMACOLOGICAL AGENTS

Leaders:
Isaac Pessah
Alan Williams

Time Speaker Topic
09:00-09:30 Isaac Pessah Variations in sensitivity of Ryr isoforms to physiologic and pharmacologic modulators.
09:30-10:00 Graham Lamb Effects of SR Ca2+loading level and cytoplasmic factors on Ca2+ release by depolarization or caffeine in skinned fibers.
10:00-10:30 Sandor Gyorke Ca2+ regulation of ryanodine receptors.
10:30-11:00 coffee break
11:00-11:30 Poster highlights
11:30-12:00 Cecilia Hidalgo Effects of SH oxidation on the regulation of ryanodine receptor function by Ca2+ and Mg2+.
12:00-12:30 Alan Williams The interaction of novel ryanoids with the single RyR channels.

Evening Session

VII. ELEMENTARY EVENTS OF Ca2+ RELEASE

Leaders:
Eduardo Rios
Gil Weir

Time Speaker Topic
19:30-19:45 Eduardo Rios Unanswered questions about Ca2+ sparks
19:45-20:15 Ernst Niggli Cellular and subcellular refractoriness of Ca2+-release in cardiac muscle.
20:15-20:45 Heping Cheng Coupling of single L-type channels to Ca2+ sparks in heart.
20:45-21:15 Ian Parker Puffs, blips, sparks and quarks: comparative anatomy of elementary Ca2+ events.
21:15-21:45 Chris Ward Modulation of local Ca2+ release events in skeletal muscle.
21:45-22:15 Adom Gonzalez Events induced by Ca release agonists in skeletal muscle. Insights from video-rate scanning microscopy.
22:15-22:30 Poster highlights
Michael Klein How many Ca2+ sparks can be released in a single sarcomere?

Thursday, June 15, 2000

Morning Session

VIII. PHYSIOLOGICAL Ca2+ RELEASE AND REUPTAKE

Leaders:
Knox Chandler
Donald Bers

Time Speaker Topic
09:00-09:45 Don Bers Integrated Ca2+ management in heart cells.
Poster highlights
Godfrey Smith Effects of reduced [ATP] on spontaneous Ca2+ release in permeabilized single cardiac cells
09:45-10:15 Mike Stern Local control theory in cardiac muscle.
10:15-10:45 coffee break
10:45-11:15 Steve Baylor Ca2+ release and spread within the sarcomere of intact skeletal muscle fibers.
11:15-12:00 Natalia Shirokova Control of Ca2+ release in mammalian skeletal muscle.
Poster highlights
Carlo Caputo Potentiation of Ca2+ release affects its Ca2+ dependent inactivation.
12:00-12:30 David Allen Ca2+ release, Ca2+ stores and muscle fatigue.

Evening Session

IX. RyR3, IP3R AND OTHER E/C COUPLING PROTEINS IN STRIATED MUSCLE

Leaders:
Barbara Block
Yasuo Ogawa

Time Speaker Topic
19:30-20:00 Yasuo Ogawa Different contributions between alpha-RyR and beta-RyR to CICR activity in sarcoplasmic reticulum vesicles from frog skeletal muscles.
20:00-20:15 Barbara Block Fiber type specific ryanodine receptors in fish.
20:15-20:45 Vincenzo Sorrentino Functional properties and mechanisms of subcellular localization of RyR3 channels.
20:45-21:15 Hiroshi Takeshima Mitsugumins - new protein components of the triad junction.
21:15-21:45 Masamitsu Iino Structure-function relationships in the IP3 receptor.
21:45-22:15 Enrique Jaimovich Function and subcellular localization of IP3R in muscle cells.

Conference Links

Conference History
Additional Fee Info

Calcium Signaling
June 30 - July 5, 2024
Cardiac Regulatory Mechanisms
June 23 - 28, 2024
Muscle: Excitation-Contraction Coupling (GRS)
May 31 - June 1, 2025
Myogenesis
June 8 - 13, 2025
Tissue Microstructure Imaging
July 13 - 18, 2025


Contact Us

MyGRC Account
Check your application status, complete your registration, update your poster, change your rooming preference, make a bus reservation, print an invitation letter, print a receipt (which includes verification that you are presenting a poster) or print an invoice by logging into your account.

GRC Venues
Everything you need to know, to plan your trip.

FAQs
Instant answers to common questions.

Tell us how we can help

Call us and leave a detailed message at: 401-783-4011

*This voicemail is only checked once daily. Due to high volume of requests during the conference season, responses may be delayed.

You have no notifications