| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STRUCTURE, ORGANIZATION AND DEVELOPMENT OF CA2+ RELEASE UNITS AND CHANNELS |
| Leaders: Clara Franzini-Armstrong & Terry Wagenknecht |
| Irina Serysheva
Structural Insights into E-C coupling by Electron Cryomicroscopy and Single Particle Analysis |
| Matthias Wolf
Structure of an L-Type Calcium Channel |
| Feliciano Protasi
Regions of Skeletal Muscle RyR and DHPR that are Critical for Their Structural Interaction |
| David MacLennan
Modeling of Phospholamban-, Sarcolipin-, Ca2+- ATPase Interactions |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DHPR AND DHPR-RyR INTERACTIONS |
| Leaders: Roberto Coronado & Kurt Beam |
| Roberto Coronado
Cellular/ Molecular EC coupling |
| Kurt Beam
Cellular/Molecular EC coupling |
| Coffee Break and Group Photo |
| Bernhard Flucher
Structural determinants of DHPR-RyR interactions |
| Angela Dulhunty
Interaction between cardiac DHPR and cardiac RyR |
| Jorge A. Sanchez
Actions of the beta subunit on DHPR currents and Ca signals in adult skeletal muscle fibers |
| Poster highlights |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENETIC DISEASES OF EC COUPLING |
| Leaders: Robert Dirksen & Frank Lehmann-Horn |
| Karin Jurkat-Rott
Unexpected news on periodic paralysis |
| Benedikt Schoser
Caveolinopathies |
| Andy Marks
Effects of RyR2 Mutations that cause CPVT |
| Poster Highlights |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ELEMENTARY CA2+ RELEASE EVENTS IN AMPHIBIAN AND MAMMALIAN MUSCLE AND
MYOTUBES |
| Leaders: Eduardo Rios & Mike Klein |
| Steve Hollingworth
The measurement and simulation of calcium sparks in frog skeletal muscle fibers |
| Peace Cheng
The Quantal Substructure in Cardiac Muscle Sparks |
| Sandor Gyorke
Modulation of Ca release by luminal Ca and Calsequestrin in Cardiac Muscle |
| John Walsh
Of STOCs and STICs - and perhaps Syntillas |
| Discussants:
John Sutko
Imaging Single Cardiac Ryanodine Receptor Ca2+ Fluxes in Lipid Bilayers
Julio Copello
Coordinated gating of ryanodine receptors/calcium release channels |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MOLECULAR MANIPULATION, EXPRESSION AND CHARACTERIZATION OF EC COUPLING COMPONENTS |
| Leaders: Paul Allen & Giuseppe Inesi |
| Hiroshi Takeshima
Junctional membrane complexes and E-C coupling |
| S.R.Wayne Chen
The Ryanodine Receptor Conduction Pore: Insights from Heterologous Expression studies |
| Claudio Perez
Using dyspedic myotubes for structure/functional mapping of E-C coupling |
| Joachim Schmitt
Knock-ins, knock-outs and upregulation - the role of transgenics in studying myogenic protein structure function relationships |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ROUND TABLE ON ACCESSORY PROTEIN AND BIOCHEMICAL MODULATORS OF EC COUPLING |
| Leaders: Hector Valdivia & Susan Hamilton |
| ACCESSORY PROTEINS OF RYRS |
| Hector Valdivia
Introduction |
| Emily Farrell
Sorcin and FKBP |
| G. Meissner
Calmodulin |
| Isaac Pessah
Homer |
| Do Han Kim
Calsequestrin-Junctin-Triadin |
| Coffee break |
| ENDOGENOUS REGULATORS OF RYR |
| Paulina Donoso
Redox modulation RyR channel-mediated calcium release kinetics |
| Mike Fill
Ca2+ |
| Poster on accessory proteins/endogenous regulators |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENERATING, TERMINATING AND REPEATING CALCIUM TRANSIENTS AND CONTRACTILE ACTIVATION |
| Leaders: Julio Vergara & David Allen |
| David Allen
Introduction |
| Carlo Caputo
Activation and inactivation Ca release parameters in mammalian and amphibian muscle fibers |
| Hakan Westerblad
Calmodulin kinase affects E-C coupling in intact skeletal muscle fibers |
| Ernst Nigli
Ca release termination and refractoriness |
| Graham Lamb
Action potential induced Ca2+ release at different store loads in skinned fibers |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | LONG-TERM EFFECTS OF MUSCLE ACTIVATION: EXCITATION-TRANSCRIPTION COUPLING |
| Leaders: Grace Pavlath & Frank Booth |
| Robin Michel
Calcineurin signaling of gene expression in skeletal muscle |
| Enrique Jaimovich
IP3 mediated calcium signals in skeletal muscle cells: A key to excitation transcription coupling? |
| Coffee Break |
| Patrick Mitchell
Multiple roles of calcineurin in skeletal muscle homeostasis |
| David Hood
Calcium signaling of mitochondrial biogenesis |
| Gary Diffee
Altered gene expression in heart due to exercise training |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | OTHER CA2+ PATHWAYS: STORE OPERATED ENTRY, MITOCHONDRIA, IP3R, RYR3 |
| Leaders: Jianje Ma & Gyorgy Hajnoczky |
| Jianjie Ma
Introduction; Interplay among plasma membrane, SR and mitochondria in Ca signaling of muscle cells |
| Zui Pan
Retrograde activation of store-operated calcium entry in muscle cells |
| Yasuo Ogawa
Pathways for Ca2+ entry in cardiac muscle |
| Shey-Shing Sheu
Mitochondrial ryanodine receptor |
| Award Ceremony |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
