| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 5:00 pm - 6:00 pm | Welcome Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STRUCTURAL ANALYSIS OF ECC PROTEINS |
| Discussion Leaders: Terry Wagenknecht (Wadsworth Center, Albany, NY, USA) and Angela Dulhunty (John Curtin School of Medical Research, Australian Capital Territory, Australia) |
| 7:30 pm - 7:35 pm | Conference business and welcome |
| 7:40 pm - 7:50 pm | Terry Wagenknecht (Wadsworth Center, Albany, NY, USA)
"Introduction" |
| 7:50 pm - 8:10 pm | Feliciano Protasi (Fondazione Università Gabriele d'Annunzio, Chieti, Italy)
"Spatial relationships between key calcium-handling organelles and molecules" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Montserrat Samso (Brigham and Women's Hospital, Boston, MA, USA)
"Structure of the transmembrane domain of the ryanodine receptor by cryo-electron microscopy" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Wah Chiu (Baylor College of Medicine, Houston, TX, USA)
"CryoEM of RyR1 at subnanometer resolution" |
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | Angela Dulhunty (John Curtin School of Medical Research, Australian Capital Territory, Australia)
"Unresolved issues, New Questions" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MODULATORS OF SR CALCIUM RELEASE |
| Discussion Leaders: Cecilia Hidalgo (University of Chile, Santiago, Chile) and Graham Lamb (Latrobe University, Melbourne, Australia) |
| 9:00 am - 9:15 am | Cecilia Hidalgo (University of Chile, Santiago, Chile)
"Introduction" |
| 9:15 am - 9:35 am | Gerhard Meissner (University of North Carolina, Chapel Hill NC, USA)
"SR Ca2+ release and ryanodine receptor associated proteins" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Andrew Marks (Columbia University, New York, NY, USA)
"Regulation of ryanodine receptors via macromolecular signaling complexes" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break / Group Photo |
| 10:55 am - 11:15 am | Donald Bers (Loyola University, Chicago, IL. USA)
"CaMKII and regulation of SR Ca2+ Release in EC Coupling" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Derek Laver (School of Biomedical Sciences and Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia)
"Cytoplasmic Regulation of RyRs and its role in termination of Ca2+ Release in EC Coupling" |
| 11:50 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Poster Highlights |
| 12:20 pm -12:30 pm | Graham Lamb (Latrobe University, Melbourne, Australia)
"Unresolved Issues, New Questions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DHPR-RYR INTERACTIONS |
| Discussion Leaders: Paul Allen (Brigham and Women's Hospital, Boston, MA, USA) and Bernhard Flucher (Innsbruck Medical University, Innsbruck, Austria) |
| 7:30 pm - 7:40 pm | Bernhard Flucher (Innsbruck Medical University, Innsbruck, Austria)
"Introduction" |
| 7:40 pm - 8:00 pm | Henry Colecraft (Johns Hopkins University School of Medicine, Baltimore, MD, USA)
"Properties of beta-subunits of voltage-dependent Ca2+ channels" |
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Manfred Grabner (Innsbruck Medical University, Innsbruck, Austria)
"Role of the DHPR ß subunit in skeletal muscle EC coupling" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Nancy Lorenzon (Colorado State, Fort Collins, CO, USA)
"Arrangement of proteins involved in skeletal muscle ECC" |
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | Paul Allen (Brigham and Women's Hospital, Boston, MA, USA)
"Unresolved Issues, New Questions" |
| 9:30 pm | Social time in poster room |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MUSCLE DISEASE |
| Discussion Leader: Kurt Beam (University of Colorado Health Science Center, Denver, CO, USA) |
| 9:00 am - 9:15 am | Kurt Beam (University of Colorado Health Science Center, Denver, CO , USA)
"Introduction" |
| 9:15 am - 9:35 am | Frank Lehmann-Horn (Ulm University, Ulm, Germany)
"The temperature dependence of skeletal muscle voltage sensor mutations - comparison of electrophysiological and 23Na MRI data" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Francesco Muntoni (Imperial College, London, UK)
"The spectrum of clinical and pathological features in patients with dominant and recessive RyR1 mutations" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Wayne Chen (University of Calgary, Alberta, Canada)
"Luminal Ca2+ Activation of Ryanodine Receptors and Its Role in Diseases" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Robert Dirksen (University of Rochester, Rochester, NY, USA)
"Murine Models of Malignant Hyperthermia: Insights into Pathophysiology and Intervention" |
| 11:50 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 am | Poster Highlights |
| 12:20 pm - 12:30 pm | Kurt Beam (University of Colorado Health Science Center, Denver, CO , USA)
"Unresolved Issues, New Questions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | REGULATION OF SR CALCIUM RELEASE |
| Discussion Leaders: Steve Hollingworth (University of Pennsylvania, Philadelphia, PA, USA) and Eduardo Rios (Rush University Medical School, Chicago, IL, USA) |
| 7:30 pm - 7:40 pm | Steve Hollingworth (University of Pennsylvania, Philadelphia, PA, USA)
"Introduction" |
| 7:40 pm - 8:00 pm | Knox Chandler (Yale University School of Medicine, New Haven, CT, USA)
"Brief Ca2+ release events or sparks in intact skeletal muscle fibers" |
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Sandor Gyorke (Ohio State University, Columbus, OH, USA)
"Modulation of SR calcium release by intra-store calcium and luminal accessory proteins in health and disease" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Hepeng Cheng (NIH, Baltimore, MD, USA)
"Calcium Blinks in the SR" |
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | Eduardo Rios (Rush University Medical School, Chicago, IL, USA)
"Unresolved Issues, New Questions" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | OTHER CONTRIBUTORS TO THE REGULATION OF INTRACELLULAR CALCIUM HOMEOSTASIS |
| Discussion Leaders: Isaac Pessah (University of California Davis, Davis, CA, USA) and Michael Fill (Rush University School of Medicine, Chicago, IL, USA) |
| 9:00 am - 9:15 am | Michael Fill (Rush University School of Medicine, Chicago IL, USA)
"Introduction" |
| 9:15 am - 9:35 am | Richard Lewis (Stanford University, Stanford, CA, USA)
"Control of CRAC channel activation by calcium in the ER" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Masamitsu Iino (The University of Tokyo, Tokyo, Japan)
"Mechanisms of IP3 receptor-mediated Ca2+ oscillations" |
| 10:10am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Francesco Zorzato (University of Ferrara, Italy)
"Junctate Modulated Ca2+ Release from the endo(sarco)plasmic reticulum" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Nagomi Kurebayashi (Juntendo University School of Medicine, Japan)
"Regulation of intracellular Ca2+ by intercellular communication in cardiac muscle" |
| 11:50 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Poster Highlights |
| 12:20 pm -12:30 pm | Isaac Pessah (University of California Davis, Davis, CA, USA)
"Unresolved Issues, New Questions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | EXCITATION-TRANSCRIPTION COUPLING |
| Discussion Leader: Ricardo Dolmetsch (Stanford University School of Medicine, Stanford, CA, USA) |
| 7:30 pm - 7:40 pm | Ricardo Dolmetsch (Stanford University School of Medicine, Stanford, CA, USA)
"Introduction" |
| 7:40 pm - 8:00 pm | Johannes Backs (University of Texas Southwestern, Dallas, TX, USA)
"Control of muscle growth and development by calcium dependent transcription" |
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Jeff Molkentin (University of Cincinnati, Cincinnati, OH, USA)
"Source of calcium that activates calcineurin-NFAT in the heart" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Martin Schneider (University of Maryland, Baltimore, MD, USA)
"Activity dependent Ca2+ signaling in skeletal muscle fiber type plasticity" |
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | Ricardo Dolmetsch (Stanford University School of Medicine, Stanford, CA, USA)
"Unresolved Issues, New Questions" |
| 9:30 pm | Social time in poster room |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MUSCLE MEMBRANE DAMAGE AND REPAIR |
| Discussion Leaders: Kevin Campbell (University of Iowa, Iowa City, IA, USA) and Osvaldo Delbono (Wake Forest University, Winston-Salem. NC, USA) |
| 9:00 am - 9:15 am | Osvaldo Delbono (Wake Forest University, Winston-Salem. NC, USA)
"Introduction" |
| 9:15 am - 9:35 am | Jean-Marie Gillis (Catholic University of Louvain, Brussels, Belgium)
"Physiological/pathological factor(s) activating Ca2+-dependent proteolysis in dystrophin deficient fibers from the mdx mouse" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am -10:10 am | David Allen (University of Sidney, Australia)
"Role of stretch-activated channels in stretch induced muscle damage: relevance to muscular dystrophy" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Paul McNeil (Medical College of Georgia, Georgia, GA, USA)
"Mechanisms of Membrane Repair" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Renzhi Han (University of Iowa, Iowa City, IA, USA)
"Defective membrane repair: a novel mechanism for muscular dystrophy and cardiomyopathy" |
| 11:50 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Poster Highlights |
| 12:20 pm - 12:30 pm | Kevin Campbell (University of Iowa, Iowa City, IA, USA)
"Unresolved Issues, New Questions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ROLES FOR RYRS IN OTHER TISSUES |
| Discussion Leaders: Mark Nelson (University of Vermont College of Medicine, Burlington, VT, USA) and John Walsh (University of Massachusetts Medical Center, Worchester, MA, USA) |
| 7:30 pm - 7:40 pm | Mark Nelson (University of Vermont College of Medicine, Burlington, VT, USA)
"Introduction" |
| 7:40 pm - 8:00 pm | Mike Kotlikoff (Cornell University, New York, NY, USA)
"RyRs in smooth and cardiac muscle" |
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Sukumar Vijayaraghavan (University of Colorado Health Science Center, Denver)
"Presynaptic RyRs and Glutamate Release at Mossy Fiber Terminals of the Rat Hippocampus" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Valerie DeCrescenzo (University of Massachusetts Medical Center, Worchester, MA, USA)
"Nerve terminals "muscle-in" on RyR1: Probing the mechanisms for mobilization of ryanodine sensitive internal Ca2+ stores by depolarization without Ca2+influx in nerve terminals" |
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | John Walsh (University of Massachusetts Medical Center, Worchester, MA, USA)
"Unresolved Issues, New Questions" |
| 9:30 pm | Social time in poster room |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
