Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
What's New in Calcium Channels Structure?
Discussion Leader: Filip Van Petegem (University of British Columbia, Canada)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Oliver Clarke (Columbia University, USA)
"Structural Studies of RyR1 Gating"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Wayne Chen (University of Calgary, Canada)
"Structure of RyR2"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Jianping Wu (Tsinghua University, China)
"Structure of CaV1.1"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Hanting Yang (Institute of Biophysics, Chinese Academy of Sciences, China)
"Pore Architecture and Gating Mechanism of TRIC Channels"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Assembly
and Maintenance of the Triad/Dyad
Discussion Leader: Eduardo Rios (Rush Medical College, Rush University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Robin Shaw (Cedars-Sinai Medical Center / University of California, Los Angeles, USA)
"The Role of BIN1 in DHPR Traffic and Regulation of Dyad Associated Microdomains"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Edgar Gomes (Instituto de Medicina Molecular (IMM), Portugal)
"Mechanisms of Triad Formation and Nuclear Positioning in Skeletal Muscle"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Benjamin Prosser (University of Pennsylvania, USA)
"Microtubule Modulation of Cardiomyocyte Contraction"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:25 am
Long-Sheng Song (University of Iowa, USA)
"Junctophilin-2 and Cardiac T-Tubule Organization"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Stephen Cannon (David Geffen School of Medicine at UCLA, USA)
"Stac3 Enhanced Expression of Human CaV1.1 in Xenopus Oocytes to Characterize HypoPP Mutant Channels"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Julien Fauré (Université Grenoble Alpes, France)
"Triadin Trafficking in Sarcoplasmic Reticulum Sub-Domains"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Susan Hamilton (Baylor College of Medicine, USA) and Clara Franzini-Armstrong (University of Pennsylvania, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Secondary Alteration of EC Coupling in Myopathies and Cardiac Diseases
Discussion Leader: Donald Bers (University of California, Davis, USA)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Karin Sipido (KU Leuven, Belgium)
"E-C Coupling and Microdomain Signaling in Ischemic Cardiomyopathy"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Ester Zito (Istituto di Ricerche Farmacologiche Mario Negri, Italy)
"Regulation of SERCA Pump Activity in SEPN1-Related Myopathies"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Daniel Michele (University of Michigan, USA)
"Sarcolemma Integrity and Muscle Dysfunction in Dystrophic Muscle"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
Daphne Atlas (The Hebrew University of Jerusalem, Israel)
"The Voltage-Gated Calcium Channel Is the Ca2+ Sensor of Cardiac Contraction"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Convergent/Divergent Mechanisms and Phenotypes in Related Disorders
Discussion Leader: Nagomi Kurebayashi (Juntendo University, Japan)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Phil Hopkins (Leeds Institute of Biomedical and Clinical Sciences, United Kingdom)
"MH and Exertional Heat Stroke"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Kevin Tylock (University of Rochester Medical Center, USA)
"Molecular and Physiological Mechanisms for QRS- and QT-Interval Prolongation in Mice with Cardiac Expression of Expanded CUG-Repeat mRNA"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Ana Gomez (INSERM, France)
"Diverse Arrhythmogenic Mechanisms in CPVT1"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
Mariana Casas (Universidad de Chile, Chile)
"Functional Cross Talk Between the Dihydropyridine Receptor and Pannexin 1 in Skeletal Muscle"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Duilio Potenza (University of Bern, Switzerland)
"Ablation of the RyR2-Ser2030 Phosphorylation Site Limits Changes in RyR2 Sensitivity During β-Adrenergic Stimulation"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Takashi Murayama (Juntendo University School of Medicine, Japan)
"Novel CPVT Mutations in RyR2 with Altered Response to CICR Ligand"
11:50 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ongoing Clinical Trials for Myopathies with EC Coupling Alteration
Discussion Leader: Susan Treves (University Hospital of Basel, Switzerland)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Caroline Le Guiner (UMR 1089, INSERM / University of Nantes, France)
"AAV Vectors as Potential Therapeutics for Duchenne Muscular Dystrophy"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Katy Meilleur (National Institute of Nursing Research, NIH, USA)
"Update on N-Acetylcysteine Trial in RYR1-Related Myopathy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Omid Haji-Ghassemi (University of British Columbia, Canada)
"Probing the Role of PKA and CaMKII Phosphorylation on the Cardiac Ryanodine Receptor"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
Razvan Cornea (University of Minnesota, USA)
"High-Throughput Screening to Discover Allosteric Inhibitors of Leaky RyR2 for Heart Failure and Arrhythmia Therapy"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Future Directions for Therapeutic Development
Discussion Leader: Robert Dirksen (University of Rochester Medical Center, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Eric Olson (University of Texas Southwestern Medical Center, USA)
"CRISPR/Cas9 for Muscle Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Cesare Terracciano (Imperial Centre for Translational and Experimental Medicine, United Kingdom)
"Excitation-Contraction Coupling Plasticity in Pluripotent Stem Cell-Derived Cardiac Myocytes"
10:10 am - 10:30 am
Discussion
10:30 am - 11:10 am
Coffee Break
11:10 am - 11:25 am
Michael Fill (Rush University Medical Center, USA)
"Preventing Ca Evoked Arrhythmias with Ryanodine Receptor Targeted Drugs"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Przemyslaw Radwanski (The Ohio State University, USA)
"Enhanced Neuronal Na+ Channel Activity Associated with Arrhythmogenic Calmodulin Mutations"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
James Dowling (Hospital for Sick Children, Canada)
"Myotubular Myopathy and Excitation Contraction Coupling: From Pathomechanism(s) to Therapy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Pivotal Role of Mitochondria
Discussion Leader: Shey-Shing Sheu (Thomas Jefferson University, USA)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Brian O'Rourke (Johns Hopkins University, USA)
"Oxidative Stress and Mitochondria in Cardiomyocytes"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Livia Hool (University of Western Australia, Australia)
"Determining Efficacy of Therapy to Reverse Duchenne Muscular Dystrophy Cardiomyopathy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
W. Jonathan Lederer (University of Maryland School of Medicine, USA)
"Regulation of Metabolism in Individual Mitochondria During E-C Coupling"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
Enrique Jaimovich (Universidad de Chile, Chile)
"Excitation-Metabolism Coupling in Skeletal Muscle"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
The Accessory Proteins
Discussion Leader: Jianje Ma (Ohio State University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Alexander Polster (University of Colorado Denver, USA)
"Identifying Proteins Essential for Skeletal-Type EC Coupling Calcium Release"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Francesco Zorzato (University of Ferrara, Italy)
"JP45 and CSQ"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Alicia Mattiazzi (National University of La Plata, Argentina)
"Phospholamban Modification to Rescue Arrhythmias Related to RyR2 Phosphorylation"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:25 am
Rebecca Sitsapesan (University of Oxford, United Kingdom)
"Role of MG 23 in Skeletal Muscle"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Marta Campiglio (Medical University of Innsbruck, Austria)
"Chimeric Approach Reveals the Domains of the STAC3/CaV1.1 Interaction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Vincenzo Sorrentino (University of Siena, Italy)
"Identification and Characterization of Mutations in the CASQ1 Gene in Patients with Tubular Aggregate Myopathy (TAM)"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Physiological
and Pathophysiological Calcium Entry
Discussion Leader: Bernhard Flucher (Medical University of Innsbruck, Austria)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Saturo Noguchi (National Institute of Neuroscience, Japan)
"Functional Effect of ORAI1 Mutations in Muscle Diseases"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Simona Boncompagni ("G. d'Annunzio" University of Chieti-Pescara, Italy)
"Exercise-Dependent Formation of New SR-TT Junctions Which Promotes Increased STIM1-Orai1 Colocalization"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Beatrix Dienes (University of Debrecen, Hungary)
"Role of Calcium Flux Through DHPR"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Clara Franzini-Armstrong (University of Pennsylvania, USA)
"What Structure Tells You if You Look"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure