Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Advances in RyR Post-Translation Modification and Clustering
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"RyR2 Rearrangement Within the Dyadic Cleft: Causes and Consequences"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Regulation of RyR by SPEG"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Nitration Attack on RyRs"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"CaMKII Increases Susceptibility to Cardiac Alternans"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein-Protein Allosterics and Their Role in ECC
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Molecular Transitions that Initiate EC Coupling in Heart and Muscle"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Allosteric Regulation of Ryanodine Receptors and TRIC Channels"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Sodium Channel Coupling"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Structural Analysis of Recombinant Ryanodine Receptors by Cryo-EM"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"The Cardiac Ryanodine Receptor Phosphorylation Hot Spot Embraces PKA in a Phosphorylation-Dependent Manner"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ion Homeostasis Control in Muscle and Disease
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Junctional Membrane Calcium Dynamics in Skeletal Muscle Fibres"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"RyR Modification in Skeletal and Cardiac Muscle"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Substitution of Asn by Asp at Entrance of the Pore Region Conditions Ion Selectivity of Voltage-Gated Ca2+ Channels in Skeletal Muscle from a Non-Ca2+ Conducting Dihydropyridine Receptor Mouse Model"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Unravelling Molecular Mechanisms of Skeletal Excitation-Contraction Coupling Using NMR "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Malignant Hyperthermia and Muscle Disease Mutations
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Unraveling the Genetics of Malignant Hyperthermia"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Metabolomic Derangements in Patients with Malignant Hyperthermia"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Examining Muscle Dysfunction in a Mouse Model of Human CSQ1-Linked Myopathy"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Caffeine or Halothane? Discordant Muscle Responses Associated with Divergent Calcium Management in MH Patients"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Mouse Model of Severe Recessive RYR1-Related Myopathy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
ECC and Therapeutic Discovery Beyond Muscle
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"From Bone-Muscle Crosstalk to New Approaches to Understand, Diagnose and Treat the Musculoskeletal Unit"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Role of Skeletal Muscle in ALS Pathogenesis and Progression"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Ryanodine Receptor Calcium Release Channels in Alzheimer's Disease"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Transverse Tubule Remodeling Enhances Orai1-Dependent Ca2+ Entry in Skeletal Muscle"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Calmodulin Functions in Muscle Health and Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Mutation Spectrum in Calmodulin: A Genetic Tale"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Calmodulinopathy: Chameleon Among Inherited Arrhythmia Disorders"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"The Many Faces of Calmodulin Mutations"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Tuning CaM Signaling to CaV Channels by Stac Proteins"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"The F141L Mutation in Human Calmodulin Disrupts the Structure and Leads to Misregulation of a Cardiac Voltage-Gated Calcium Channel"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Fret-Based Trilateration Resolves Distinct Structural States and Transitions of Calmodulin Bound to RyR "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RyRs and CaVs: Targets for Small Molecules and Proteins
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"The Calcin Family of Ryanodine Receptor Ligands: The Hidden Salutary Effect of Scorpion Toxins"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Structural Biology Drives Drug Discovery Targeting the Pathological Leak of RyR Channels"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Identification of Novel RyR1 Inhibitors by High-Throughput Screening with ER Ca2+ Measurement"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Mechanisms of Enhanced Heat Sensitivity Associated RyR1-MH Mutations"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Novel Therapeutic Directions for ECC Disorders
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"RyR Structure Provides Clues for Therapeutics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"RyR1 Deficiency, a New Mouse Model of Core Myopathy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"RYR1 NAC Trial Results and Beyond: First and Future Clinical Trials for RYR1-Related Disorders"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Exercise Prevents Formation of Tubular Aggregates in Ageing Skeletal Muscle Fibers"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mitochondrial Nanotunnels Are Specific to Cardiac Myocytes and Are Inducible"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Increase in RyR2-Mediated Ca2+ Leak Promotes Mito-ROS Production Without Changing Mitochondrial Ca2+ Content in Ventricular Cardiomyoytes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Essential Components for E-C Coupling
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Molecular Tuning of CaV1.1 for Its Specific Functions in Skeletal Muscle"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"The (Ir)relevance of DHPR Calcium Influx in Skeletal Muscle"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:50 pm
"Dissecting the Molecular Interactions Underlying EC-Coupling Calcium Release in Skeletal Muscle"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure