Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Advances in RyR Post-Translation Modification and Clustering
Discussion Leader: Montserrat Samso (Virginia Commonwealth University, USA)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Edwin Moore (University of British Columbia, Canada)
"RyR2 Rearrangement Within the Dyadic Cleft: Causes and Consequences"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Xander Wehrens (Baylor College of Medicine, USA)
"Regulation of RyR by SPEG"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Johanna Lanner (Karolinska Institutet, Sweden)
"Nitration Attack on RyRs"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Giedrius Kanaporis (Rush University Medical Center, USA)
"CaMKII Increases Susceptibility to Cardiac Alternans"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein-Protein Allosterics and Their Role in ECC
Discussion Leader: Rafael Mejia-Alvarez (Midwestern University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Riccardo Olcese (University of California, Los Angeles, USA)
"The Molecular Transitions that Initiate EC Coupling in Heart and Muscle"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Elisa Venturi (University of Oxford, United Kingdom)
"Allosteric Regulation of Ryanodine Receptors and TRIC Channels"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Isabelle Deschenes (Case Western Reserve University, USA)
"Sodium Channel Coupling"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Haruo Ogawa (Institute for Quantitative Biosciences, The University of Tokyo, Japan)
"Structural Analysis of Recombinant Ryanodine Receptors by Cryo-EM"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Omid Haji-Ghassemi (University of British Columbia, Canada)
"The Cardiac Ryanodine Receptor Phosphorylation Hot Spot Embraces PKA in a Phosphorylation-Dependent Manner"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Xun Ai (Rush University Medical Center, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ion Homeostasis Control in Muscle and Disease
Discussion Leader: Dirk Gillespie (Rush University Medical Center, USA)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Bradley Launikonis (The University of Queensland, Australia)
"Junctional Membrane Calcium Dynamics in Skeletal Muscle Fibres"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Nicole Beard (University of Canberra, Australia)
"RyR Modification in Skeletal and Cardiac Muscle"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Bruno Allard (Université Claude Bernard Lyon 1, France)
"Substitution of Asn by Asp at Entrance of the Pore Region Conditions Ion Selectivity of Voltage-Gated Ca2+ Channels in Skeletal Muscle from a Non-Ca2+ Conducting Dihydropyridine Receptor Mouse Model"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Dmitry Shishmarev (Australian National University, Australia)
"Unravelling Molecular Mechanisms of Skeletal Excitation-Contraction Coupling Using NMR "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Malignant Hyperthermia and Muscle Disease Mutations
Discussion Leader: Claudio Perez (Brigham and Women's Hospital, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
James Dowling (Hospital for Sick Children, Canada)
"Unraveling the Genetics of Malignant Hyperthermia"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Sheila Riazi (University of Toronto, Canada)
"Metabolomic Derangements in Patients with Malignant Hyperthermia"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Amy Hanna (Baylor College of Medicine, USA)
"Examining Muscle Dysfunction in a Mouse Model of Human CSQ1-Linked Myopathy"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Lourdes Figueroa (Rush University Medical Center, USA)
"Caffeine or Halothane? Discordant Muscle Responses Associated with Divergent Calcium Management in MH Patients"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Robert Dirksen (University of Rochester Medical Center, USA)
"Mouse Model of Severe Recessive RYR1-Related Myopathy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
ECC and Therapeutic Discovery Beyond Muscle
Discussion Leader: Grace Stutzmann (Chicago Medical School, Rosalind Franklin University of Medicine and Science, USA)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Marco Brotto (University of Texas at Arlington, USA)
"From Bone-Muscle Crosstalk to New Approaches to Understand, Diagnose and Treat the Musculoskeletal Unit"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Jingsong Zhou (University of Texas at Arlington, USA)
"Role of Skeletal Muscle in ALS Pathogenesis and Progression"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Andrea Paula-Lima (University of Chile, Chile)
"Ryanodine Receptor Calcium Release Channels in Alzheimer's Disease"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Antonio Michelucci (University of Rochester, USA)
"Transverse Tubule Remodeling Enhances Orai1-Dependent Ca2+ Entry in Skeletal Muscle"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Calmodulin Functions in Muscle Health and Disease
Discussion Leader: Xun Ai (Rush University Medical Center, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Mette Nyegaard (Aarhus University, Denmark)
"The Mutation Spectrum in Calmodulin: A Genetic Tale"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Bjorn Knollmann (Vanderbilt University School of Medicine, USA)
"Calmodulinopathy: Chameleon Among Inherited Arrhythmia Disorders"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Michael Overgaard (Aalborg University, Denmark)
"The Many Faces of Calmodulin Mutations"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Manu Ben-Johny (Columbia University, USA)
"Tuning CaM Signaling to CaV Channels by Stac Proteins"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Reinhard Wimmer (Aalborg University, Denmark)
"The F141L Mutation in Human Calmodulin Disrupts the Structure and Leads to Misregulation of a Cardiac Voltage-Gated Calcium Channel"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Bengt Svensson (University of Minnesota, USA)
"Fret-Based Trilateration Resolves Distinct Structural States and Transitions of Calmodulin Bound to RyR "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RyRs and CaVs: Targets for Small Molecules and Proteins
Discussion Leader: Susan Treves (University Hospital of Basel, Switzerland)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Hector Valdivia (University of Wisconsin-Madison, USA)
"The Calcin Family of Ryanodine Receptor Ligands: The Hidden Salutary Effect of Scorpion Toxins"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Razvan Cornea (University of Minnesota, USA)
"Structural Biology Drives Drug Discovery Targeting the Pathological Leak of RyR Channels"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Takashi Murayama (Juntendo University School of Medicine, Japan)
"Identification of Novel RyR1 Inhibitors by High-Throughput Screening with ER Ca2+ Measurement"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Rachel Yee (Baylor College of Medicine, USA)
"Mechanisms of Enhanced Heat Sensitivity Associated RyR1-MH Mutations"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Novel Therapeutic Directions for ECC Disorders
Discussion Leader: Angela Dulhunty (Australian National University, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Andrew Marks (Columbia University, USA)
"RyR Structure Provides Clues for Therapeutics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Isabelle Marty (Grenoble Institut des Neurosciences (INSERM U1216), France)
"RyR1 Deficiency, a New Mouse Model of Core Myopathy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Katy Meilleur (National Institute of Nursing Research, NIH, USA)
"RYR1 NAC Trial Results and Beyond: First and Future Clinical Trials for RYR1-Related Disorders"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Simona Boncompagni (D'Annunzio University of Chieti-Pescara, Italy)
"Exercise Prevents Formation of Tubular Aggregates in Ageing Skeletal Muscle Fibers"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Clara Franzini-Armstrong (University of Pennsylvania, USA)
"Mitochondrial Nanotunnels Are Specific to Cardiac Myocytes and Are Inducible"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Shanna Hamilton (Ohio State University, USA)
"Increase in RyR2-Mediated Ca2+ Leak Promotes Mito-ROS Production Without Changing Mitochondrial Ca2+ Content in Ventricular Cardiomyoytes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Essential Components for E-C Coupling
Discussion Leader: Marta Campiglio (Medical University of Innsbruck, Austria)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Bernhard Flucher (Medical University of Innsbruck, Austria)
"Molecular Tuning of CaV1.1 for Its Specific Functions in Skeletal Muscle"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Manfred Grabner (Medical University of Innsbruck, Austria)
"The (Ir)relevance of DHPR Calcium Influx in Skeletal Muscle"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:50 pm
Kurt Beam (University of Colorado Denver, USA)
"Dissecting the Molecular Interactions Underlying EC-Coupling Calcium Release in Skeletal Muscle"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure