Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Couplon Myopathies
Discussion Leader: Erick Hernandez-Ochoa (University of Maryland School of Medicine, USA)
3:15 pm - 3:20 pm
Opening Remarks
3:20 pm - 3:50 pm
Susan Treves (University Hospital of Basel, Switzerland)
"Genetics and Epigenetic of Ryanodinopathies"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Emerging Concepts/Mechanisms in Excitation-Contraction Coupling
Discussion Leaders: Omid Haji-Ghassemi (University of British Columbia, Canada) and Ester Zito (Fondazione Telethon, Italy)
5:30 pm - 5:50 pm
Emily Wires (National Institute of Nursing Research, NIH, USA)
"Monitoring ER/SR Calcium Depletion in Skeletal Muscle Using Exogenous and Endogenous Reporters"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Graciano Leal (Instituto de Medicina Molecular João Lobo Antunes, Portugal)
"Regulation of Excitation-Contraction Coupling by Nuclei Positioning"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Dmitry Shishmarev (Australian National University, Australia)
"Unravelling Molecular Mechanisms of Skeletal Excitation-Contraction Coupling Using NMR Spectroscopy"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Christopher Johnson (Ohio State University Wexner Medical Center / Vanderbilt University Medical Center, USA)
"The Chemistry of Tuning NaV CaM Modulation"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Function and Dysfunction of Molecular Mechanisms of Excitation-Contraction Coupling
Discussion Leaders: Parisa Asghari (University of British Columbia, Canada) and Megan McCarthy (University of Minnesota, USA)
9:00 am - 9:20 am
Antonio Michelucci (University of Rochester, USA)
"Muscles from Calsequestrin-1 Knockout Mice Contain Pre-Assembled Calcium Entry Units that Provide Constitutively Active Store-Operated Calcium Entry"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Elizabeth Martinez (Rush University, USA)
"Carvedilol Inhibits Voltage-Gated Na and Ca Channels and Modulates RyR Activity in Rabbit Atrial Myocytes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Roberto Silva Rojas (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France)
"SOCE Over-Activation Generates a Multi-Systemic Phenotype Affecting Skeletal Muscle, Spleen, Eye, Skin, Bones and the Immune System in Mice"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Michelle Munro (University of Otago, New Zealand)
"Human RyR Inter-Cluster Distance Decreases with Age but Does Not Correlate with Atrial Fibrillation"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Strategies for Funding Success and Career Opportunities
Discussion Leader: Tanya Cully (Baylor College of Medicine, USA)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:25 pm
Panel Discussion
Strategies for Funding Success and Career Opportunities
Robert Dirksen (University of Rochester Medical Center, USA)
Oliver Clarke (Columbia University, USA)
Susan Treves (University Hospital of Basel, Switzerland)
2:25 pm - 2:30 pm
Closing Remarks
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes