Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Emerging Techniques in Muscle Physiology
Discussion Leader: Lily Cisco (University of Rochester, United States)
3:45 pm - 3:55 pm
Nashwa Cheema (Harvard Medical School /Massachusetts General Hospital, United States)
"Treatment With Near Infrared Light Prevents Muscular Fatigue In In Vitro and In Vivo Models of Exercise"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Salma Geissah (Hospital for Sick Children, Canada)
"Characterization of a Novel Zebrafish Model of SPEG-Related Centronuclear Myopathy"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Britany Rufenach (University of British Columbia, Canada)
"STAC proteins interact directly with calmodulin to regulate L-type Cavs"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Concepts in Ion Regulation and Protein Interactions
Discussion Leader: Chen Liang (University of Rochester, United States)
7:30 pm - 7:40 pm
Simone Pelizzari (Medical University of Innsbruck, Austria)
"A Single Voltage-Sensor of CaV 1.1 Activates Skeletal Muscle Excitation-Contraction Coupling"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Yu Seby Chen (University of British Columbia, Canada)
"Investigating the Structural and Functional Impacts of Malignant Hyperthermia-Causing Mutations in Ryanodine Receptor 1"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Rui Luo (INSERM UMRS1180, France)
"STIM2 Variants Regulate Orai1-Mediated Store-Operated Ca2+ Entry in Cardiomyocytes"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Roman Medvedev (University of Wisconsin-Madison, United States)
"Caveolae Mediate cAMP/PKA/Ca2+ Signal Transduction in Mouse Atrial Cardiomyocytes"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
General Discussion
8:45 pm - 8:55 pm
Jingjing Zheng (University of Wisconsin-Madison, United States)
"Ablation of the Three Major Phosphorylation Sites in RyR2 Predisposes to Arrhythmia in Mice"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Sarah Teboull (INSERM PARIS IDF-SUD, France)
"Role of RyR2-S2030 Phosphorylation During the ß-adrenergic Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Callum Quinn (University of Manchester, United Kingdom)
"Understanding the Relationship Between Dysferlin, Transverse (t)-Tubules & Arrhythmias"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
New Mechanisms and Treatments in ECC Diseases
Discussion Leader: Francisco Jaque (Université Claude Bernard Lyon 1, France)
9:00 am - 9:10 am
Nan Zhao (University of Rochester, United States)
"Characterization of the Orai1G100S/+ Mouse Model of Tubular Aggregate Myopathy"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Qian Shi (University of Iowa, United States)
"IRS2, a Novel Regulator of Ca2+ Homeostasis and Arrhythmias in Heart"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Ting Chang (Baylor College of Medicine, United States)
"The Role of Junctin (JNC) in Muscle Function"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Vladimir Bogdanov (Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, United States)
"HF Alters Distribution and Spatial Association Profiles of CaM and CaM Target Protein mRNAs"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Avoiding Common Pitfalls and Maximizing Opportunities
Katharine Dibb (University of Manchester, United Kingdom)
Jeff Erickson (University of Otago, New Zealand)
Ana Gomez (INSERM, France)
Donald Bers (University of California, Davis, United States)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Keynote Session
Discussion Leader: Marta Campiglio (Medical University of Innsbruck, Austria)
1:30 pm - 2:15 pm
W. Jonathan Lederer (University of Maryland School of Medicine, United States)
"Novel Regulation of ATP Production by Mitochondria in Heart"
2:15 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes