SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | HUMAN DISEASES AND ANIMAL MODELS |
| Discussion Leader: Freddie Fu (University of Pittsburgh) |
7:35 pm - 7:50 pm | Freddie Fu (University of Pittsburgh)
"Anatomical Approach to ACL Reconstruction" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Kurt Spindler (Vanderbilt University)
"Clinical Outcome-Based Predictors for Tissue Engineering" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:30 pm | Joseph Iannotti (Cleveland Clinic)
"Clinical Challenges for Enhancing Rotator Cuff Repair Using Tissue Engineering Appoaches: Role of Tissue Patches" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:50 pm | Matthew Allen (Ohio State University)
"Rational Selection of Animal Models for Musculoskeletal Research" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:10 pm | Howard An (Rush Medical College)
"Animal Models to Study Intervertebral Disc Degeneration and Biological Regeneration" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Presentation selected from submitted abstracts: |
| Peter Amadio (Mayo Clinic)
"A novel animal model for carpal tunnel syndrome" |
9:25 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | TISSUE ENGINEERING AND REGENERATION |
| Discussion Leader: Jennifer Elisseeff (Johns Hopkins University) |
9:00 am - 9:15 am | Martha Murray (Boston Children's Hospital / Harvard)
"Repair and Regeneration of the ACL" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Ulrich Noth (University of Wurzburg, Germany)
"Collagen Hydrogel-Based Articular Cartilage Repair" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Ravi Bellamkonda (Georgia Tech)
"Engineering Re-innervation of Denervated Skeletal Muscle" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:45 am | Jennifer Elisseeff (Johns Hopkins University)
"Engineering in the Normal and Diseased Musculoskeletal System" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Miqin Zhang (University of Washington)
"Natural Polymer Scaffolds for Bone Tissue Regeneration" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Ken Muneoka (Tulane University)
"BMP Signaling is Required for Mouse Digit Regeneration" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Presentations selected from submitted abstracts: |
| Kristen Moffatt (Columbia Univ) "Nanofiber-Based Scaffold Systems for Tendon-to-Bone Integration" |
| Russel Fernandes (Univ Washington) "Collagen Heteropolymer Formation and Matrix assembly in Tissue-engineered Cartilage" |
| Brad Estes (Duke Univ) "Chondrogenic Differentiation of Adipose-Derived Adult Stem Cells by a Porous Scaffold Derived from Native Articular Cartilage Extracellular Matrix" |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | STEM CELL BIOLOGY |
| Discussion Leader: Oscar Lee (Veterans General Hospital, Taiwan) |
7:30 pm - 7:45 pm | George Christ (Wake Forest University)
"Stem and Progenitor Cells for Engineering of Functional Soft Tissues for Musculoskeletal Injuries" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Jeffrey Gimble (Pennington Biomed Res Inst, Lousiana State University)
"Characterization of Human Adipose-derived Stem Cells (ASCs)" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Christian Jorgensen (INSERM, Montpellier, France)
"Immunological Properties of MSC: Applications for Autoimmune Diseases" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Oscar Lee (Veterans General Hospital, Taiwan)
"Mesenchymal Stem Cells and Bone Regeneration" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Presentations selected from submitted abstracts: |
| Michael Mueller (Univ Regensburg) "Terminal Chondrocyte Differentiation in MSC Chondrogenesis - Links between Tissue Engineering and Developmental Biology" |
| Leo Wan (Columbia Univ) "Geometrical Control of Mechanical Forces and Stem Cell Differentiation" |
9:10 pm - 9:30 pm | General Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SKELETAL DEVELOPMENT |
| Discussion Leader: Karen Lyons (UCLA) |
9:00 am - 9:15 am | Kenro Kusumi (Arizona State University)
"Patterning of the Axial Skeleton in Early Development" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Robert Maxson (University of Southern California)
"EphA4 and Jagged1 as Effectors of Twist1 in the Patterned Growth of Calvarial Bones" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Karen Lyons (UCLA)
"CTGF and Cyr61 in Skeletal Development" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:45 am | William Horton (Shriners Hospital, Portland)
"Altering FGFR3 Stability as a Means to Regulate Skeletal Growth" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Benjamin Alman (Hospital for Sick Children, University of Toronto)
"What Pathology Teaches About Development: Hedgehog Signaling in Chondrocytes" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Jennifer Westendorf (Mayo Clinic)
"Transcriptional Control of Osteoblast Differentiation" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:20 pm | Presentations selected from submitted abstracts: |
| Arthur Broadus (Yale Univ) "PTHrP Regulates the Maintenance of Articular Chondrocytes" |
| Dana Cairns (Tufts Univ) "Shh Acts as a Morphogen to Establish Mutually Repressing Somitic Cell Fates Induced by Nkx3.2 and Pax3" |
| Brent Bobick (NIAMS, NIH) "Vimentin Regulates Chondrogenesis of Adult Human Bone Marrow-Derived Mesenchymal Stem Cells" |
| Sarah Snelling (Univ Oxford) "Investigating the Function of Bone Morphogenetic Protein-5 in Cartilage" |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | GENES, GENE REGULATION, AND GENE THERAPY |
| Discussion Leader: Christopher Evans (Harvard Medical School) |
7:30 pm - 7:45 pm | Christopher Evans (Harvard Medical School)
"Expedited, Gene-Based Approaches to Regenerating Bone and Cartilage" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | John Loughlin (University of Oxford)
"Polymorphism in the TGF-beta Signaling Pathway and Susceptibility to Osteoarthritis" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Joan Marini (NICHD, NIH)
"Defects in Type I Collagen Modification Cause Recessive Osteogenesis Imperfecta" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Richard Loeser (Wake Forest University)
"Redox Regulation of Anabolic and Catabolic Signaling Pathways in Cartilage: A Link Between Aging and Osteoarthritis" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Frederick Kaplan (University of Pennsylvania)
"Why Do Some People Form Two Skeletons?" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Presentation selected from submitted abstracts: |
| Takenobu Katagiri (Saitami Med Univ)
"Constitutively activated ALK2 and Increased Smad1/5 Cooperatively Induce BMP Signaling in Fibrodysplasia Ossificans Progressiva" |
9:20 pm - 9:30 pm | General Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IMAGING |
| Discussion Leader: Robert Guldberg (Georgia Tech) |
9:00 am - 9:15 am | Robert Guldberg (Georgia Tech)
"Contrast Enhanced Micro-CT Imaging of Bone and Cartilage" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Martha Gray (MIT)
"Pre-clinical and Clinical MR Imaging Studies for Osteoarthritis: Where Are We and What Are Some Opportunities Going Forward" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Ravinder Reddy (University of Pennsylvania)
"Sodium and T1rho MRI to Assess Cartilage Integrity" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:45 am | Michelle L. Reyzer (Vanderbilt University)
"Molecular Imaging and Profiling of Tissues Sections Using Mass Spectrometry: Applications in Biological and Clinical Research" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Thomas Andriacchi (Stanford University)
"A Synergy between Cartilage MR imaging and Ambulatory Biomechanics for Studying Osteoarthritis" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Presentations selected from submitted abstracts: |
| Roy Aaron (Brown Univ) "Perfusion Abnormalities in Subchondral Bone Associated with Marrow Edema, Osteoarthritis, and Avascular Necrosis" |
| Clarissa Henry (Univ Maine) "Time-Lapse Analysis and Mathematical Modeling Elucidate Novel Mechanisms Underlying Muscle Morphogenesis" |
11:40 am - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 3 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PHYSICAL REGULATION |
| Discussion Leader: Clark Hung (Columbia University) |
7:30 pm - 7:45 pm | Catherine Kuo (Tufts University)
"Mechanoregulation of Mesenchymal Differentiation" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Clark Hung (Columbia University)
"Physical Effects on Chondrocytes" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Louis Gerstenfeld (Boston University)
"Distraction Osteogenesis As An In Vivo Model of Mechanical Stimulation and the Role of Angiogenesis in DO-Mediated Bone Formation" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Stefan Judex (Tufts University)
"High Frequency Physical Signals in the Musculoskeleton" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Christopher Jacobs (Stanford University)
"Primary Cilia as Mechanosensors in Bone" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Presentation selected from submitted abstracts: |
| Elise Morgan (Boston Univ)
"Correlations Between Local Strains and Tissue Phenotypes in an Experimental Model of Skeletal Healing" |
9:20 pm - 9:30 pm | General Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:15 am | SYSTEMS BIOLOGY |
| Discussion Leader: Thomas Knudsen (Environmental Protection Agency) |
9:00 am - 9:15 am | Thomas Knudsen (Environmental Protection Agency)
"Virtual Tissues in Developmental Systems Biology" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Qiang Tian (Institute for Systems Biology)
"New Technologies Enabling Systems Analysis of Stem Cell Development and Regeneration" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Andre Levchenko (Johns Hopkins University)
"Controlling cardiac function on the nano-scale: a scalable biomimetic analysis and intervention" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | General Discussion |
10:15 am | Coffee Break |
10:45 am - 12:30 pm | ENVIRONMENTAL AND GENDER-RELATED INFLUENCES |
| Discussion Leader: Edward Puzas (University of Rochester) |
10:45 am - 11:00 am | John Rogers (Environmental Protection Agency)
"Malformation of the Axial Skeleton by Environmental Agents in Rodents, and Relevance to Humans" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Edward Puzas (University of Rochester)
"Mechanisms by Which Environmental Toxicants Adversely Affect the Skeleton" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Joanne Jordan (University of North Carolina)
"Selenium Deficiency and Osteoarthritis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Adele Boskey (Hospital for Special Surgery)
"Sex Matters: Differential Effects on Bone and Cartilage Properties in Rodents and Primates" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Presentation selected from submitted abstracts: |
| Borjana Mikic (Smith College)
"The Effect of Animal Sex on Murine Tendon Composition and Mechanics During Growth" |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:00 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm - 9:30 pm | SPECIAL LECTURE |
8:00 pm - 9:00 pm | George Lauder (Professor of Organismic and Evolutionary Biology, Alexander Agassiz Professor of Zoology, Museum of Comparative Zoology, Harvard University)
"Robotic Fish: One Future for Musculoskeletal Engineering" |
9:00 pm - 9:30 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |