SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Clinical aspects of musculoskeletal disease |
| Discussion Leader: Martha Murray (Children’s Hospital, Boston) |
7:40 pm - 8:00 pm | Joseph Buckwalter (University of Iowa) "The etiopathogenesis of post-traumatic arthritis" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Gunnar Knutsen (University Hospital North Norway) "Cartilage repair: Does anything work better than microfracture?" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Lou Defrate (Duke University Medical Center) "In vivo ACL strain and joint kinematics in patients with ACL reconstruction" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jay Parvizi (Thomas Jefferson University) "Prosthetic Joint Infection After Total Hip Arthroplasty: Risk Factors and Treatments" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Systemic and genetic regulation of the musculoskeletal system |
| Discussion Leader: Nancy Lane (University of California, Davis) |
9:00 am - 9:20 am | Lynda Bonewald (University of Missouri, Kansas City) "Osteocytes as Endocrine Cells" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Stephen Trippel (Indiana University) "Role of growth factors in articular cartilage repair" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Di Chen (University of Rochester) "Beta-Catenin is A Key Mediator during the Development of Osteoarthritis and Intervertebral Disc Degeneration" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Tamara Alliston (University of California, San Francisco) "Anabolic and anti-catabolic effects of TGF-beta in the skeleton" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:30 pm | Short talks from posters: TBA |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Epigenetic Influences on the Musculoskeletal System |
| Discussion Leader: Mary Goldring (Hospital for Special Surgery) |
7:30 pm - 7:50 pm | Ko Hashimoto (Hospital for Special Surgery) "Epigenetics and aberrant gene expression in osteoarthritis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Min Du (University of Wyoming) "Maternal Obesity, Inflammation, and Fetal Skeletal Muscle Development" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Rocky Tuan (University of Pittsburgh) "Epigenetic regulation of mesenchymal stem cells" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jeffrey Dilworth (Ottawa Hospital Research Institute) "Epigenetic regulation of the skeletal muscle gene expression program" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanobiology and Bioengineering |
| Discussion Leader: Catherine Kuo (Tufts University) |
9:00 am - 9:20 am | Robert Sah (University of California, San Diego) "Mechanobiology and bioengineering of articular cartilage and synovial joints" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Yi-Xian Qin (SUNY at Stony Brook) "Bone adaptation as dependent on functional mechanobiological signals" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Stavros Thomopoulos (Washington University) "The role of mechanobiology in the attachment of tendon to bone" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | James Iatridis (University of Vermont) "Asymmetric loading promotes early signs of intervertebral disc degeneration" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:30 pm | Short talks from posters: TBA |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Non-mammalian models of musculoskeletal development and disease |
| Discussion Leader: Linda Sandell (Washington University) |
7:30 pm - 7:50 pm | Stephen F. Badylak (University of Pittsburgh) "Epimorphic regeneration of functional musculotendinous tissue" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Eileen Shore (University of Pennsylvania) "Activation of BMP-independent signaling in a zebrafish model of a human disease" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Charles Archer (University of Cardiff) "Notch signalling and other pathways in development and in OA" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Kelly Tseng (Tufts University) "Pathways that regulate Xenopus appendage regeneration" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stem cells and tissue engineering |
| Discussion Leader: Chris Evans (Brigham and Women's Hospital) |
9:00 am - 9:20 am | Johnny Huard (University of Pittsburgh)
"Regenerative medicine based on muscle stem cells: Potential for Tissue Regeneration & Repair" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Andrés Garcia (Georgia Tech)
"Biomaterial strategies for enhanced bone repair" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Anna Spagnoli (University of North Carolina) "Mesenchymal stem cells and fracture healing" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Helen Lu (Columbia University) "Engineering the soft tissue to bone interface" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:30 pm | Short talks from posters: TBA |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | High throughput analysis and systems approaches |
| Discussion Leader: Lou Gerstenfeld (Boston University) |
7:30 pm - 7:50 pm | John Bateman (Murdoch Childrens Research Institute, Victoria Australia) "Proteomics and microarray profiling to studying cartilage formation and disease" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jason Burdick (University of Pennsylvania) "High-throughput and Combinatorial Technologies for Tissue Engineering Applications" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Leonidas Alexopoulos (National Technical University of Athens) "Phosphoproteomic-based pathway analysis of cartilage degeneration" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Kurt Hankenson (University of Pennsylvania) "Transcriptional network/systems biology in the musculoskeletal system" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Imaging of Musculoskeletal Tissues |
| Discussion Leader: Roy Aaron (Brown University) |
9:00 am - 9:20 am | Connie Chu (University of Pittsburgh) "New imaging methods for enhanced clinical assessment of cartilage injury and repair" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Hollis Potter (Hospital for Special Surgery) "MRI of joint morphology, structure, and composition" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 pm | Brian Snyder (Beth Israel Deaconess Medical Center) "Predicting Pathologic Fracture Risk: Structure is more important than tissue mineral density" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Edward Schwarz (University of Rochester) "Imaging the reservoirs of bone infection" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:30 pm | Short talks from posters: TBA |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | Short Talks from Posters |
| Discussion Leader: Farshid Guilak (Duke University Medical Center) |
7:30 pm - 9:00 pm | (Speakers TBA) |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |