SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff |
7:40 pm - 7:55 pm | Welcome Remarks by Chris Evans (Mayo Clinic) |
7:55 pm - 9:30 pm | The Research Translation Landscape |
| Discussion Leader: Peter Johnson (Avery Dennison) |
7:55 pm - 8:30 pm | Cheryl Blanchard (Blanchard Consulting)
"Translating from the Lab to the Patient"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Michael Dunn (Rutgers University)
"An Academic Perspective of Translation Research" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Getting Stem Cells into the Clinic |
| Discussion Leader: George Muschler (Cleveland Clinic) |
9:00 am - 9:25 am | Malcolm Moos (FDA)
"Cell Identity - Nomenclature and Metrics"
|
9:25 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Seán Gaynard (University of Galway)
"Effect of Hypoxia on Growth Kinetics and Differentiation of MSCs Cultured in a Novel Serum/Xeno-Free Culture System"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | George Muschler (Cleveland Clinic)
"Clinical Barriers"
|
10:55 am - 11:10 am | Discussion |
11:10 am - 11:20 am | Sharon Ansboro (University of Galway)
"Tracking the Fate of Mesenchyme Progenitor Cells (MPC) Following Intra-Articular Injection in a Post-Traumatic OA Mouse Model"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Alan Davis (Baylor College of Medicine)
"Heterotopic Bone Is Derived in Large Part from Progenitors in Local Peripheral Nerves: Major Difficulties in Animal Models for BMP2 Testing"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Robert Deans (Athersys)
"Industry Perspective"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Osteoarthritis |
| Discussion Leader: Virginia Kraus (Duke Medical School) |
7:30 pm - 7:55 pm | Virginia Kraus (Duke Medical School)
"Biomarkers"
|
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Sharmila Majundar (University California, San Francisco)
"Quantitative Imaging in OA: Going Beyond Single Site Studies"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Frank Barry (NUI Galway, IE)
"Mesenchymal Stem Cells"
|
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Ligament/Tendon/Muscle |
| Discussion Leader: Lisa Larkin (University of Michigan) |
9:00 am - 9:25 am | Lisa Larkin (University of Michigan)
"Engineering Ligaments"
|
9:25 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Brian Syverud (University of Michigan)
"Engineered Skeletal Muscle Units for Repair of Volumetric Muscle Loss in the Tibialis Anterior Muscle of a Rat"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Anthony Ratcliffe (Synthasome)
"Tendon and Ligament Repair and Replacement: Transition from Translation to Commercialization" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Johnny Huard (University of Pittsburgh)
"Muscle Derived Stem Cells"
|
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Maurizio Pacifici (University of Pennsylvania)
"Drug Repurposing for the Treatment of Fibrodysplasia Ossificans Progressiva"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Gene Therapy |
| Discussion Leader: Paul Robbins (Scripps Research Institute) |
7:30 pm - 7:55 pm | Jay Lieberman (University of Southern California)
"Regional Gene Therapy for Bone Repair"
|
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Steven Ghivizzani (University of Florida)
"AAV Mediated IL-1Ra Gene Delivery to the Equine OA Joint: Pharmocokinetics and Efficacy"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Henning Madry (University of Saarland, DE)
"Gene Therapy for Cartilage Defects"
|
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Bone |
| Discussion Leader: Edward Schwarz (University of Rochester) |
9:00 am - 9:25 am | Joost de Bruijn (University of Twente, NL)
"Bone Repair Using Instructive Materials" |
9:25 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Anne Gingery (Mayo Clinic)
"TIEG Suppresses SOST Expression and Mediates the Skeletal Response to Sclerostin Antibody Therapy"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Sheldon Lin (Rutgers Medical School)
"rhPDGF: Animal Studies to Clinical FDA Trials"
|
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Ivan Martin (University of Basle, CH)
"Engineering Developmental Processes for Bone Repair"
|
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Robert Guldberg (Georgia Institute of Technology)
"Vascularization Strategies for Bone Regeneration" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Meniscus and Cartilage |
| Discussion Leader: Robert Mauck (University of Pennsylvania) |
7:30 pm - 7:55 pm | Suzanne Maher (Hospital for Special Surgery)
"Predicting the Clinical Performance of Meniscal Substitutes"
|
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Martin Englund (Lund, SE)
"The Meniscal Pathway to Knee Osteoarthritis"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Jeremy Mao (Columbia University)
"Meniscus Injury and Repair: Cell Differentiation in 3D Printed Scaffolds"
|
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Creating a Translational Research Environment |
| Discussion Leader: Cyril Frank (University of Calgary) |
9:00 am - 9:25 am | Martin Stoddart (AO Research Institue, Davos, CH)
"AO Research Institute Davos Within the AO Foundation: A Model for Translation of Science to the Clinics"
|
9:25 am - 9:40 am | Discussion |
9:40 am - 9:50 am | Elizabeth Balmayor (Technical University of Munich)
"Chemically Modified Messenger RNA as an Alternative for Non-Viral Gene Therapy" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Andrew Carr (Oxford University)
"Translational Research in Musculoskeletal Disease - The Oxford Model" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Kelly LaMarco (Science Translational Medicine)
"Biomedical Translation: Minding the Gaps"
|
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Peter Amadio (Mayo Clinic)
"The Mayo Model"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session |
| Discussion Leader: Chris Evans (Mayo Clinic) |
7:30 pm - 8:30 pm | Peter Johnson (Avery Dennison)
"Strategies and Requirements for Successful Research Translation"
|
8:30 pm - 9:00 pm | Discussion |
9:00 pm - 9:30 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |