| Sunday |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: Cross-Disciplinary Innovations in Musculoskeletal Biology and Bioengineering |
| This session will introduce the theme of our
meeting (Stepping Across Disciplines to Spur Innovation) and to provide
examples of the fruition of such cross-disciplinary interactions through two
keynotes drawn from thought leaders in our field. |
| Discussion Leaders: Robert Mauck (University of Pennsylvania, USA) and Peter Johnson (MedSurgPI, LLC, USA) |
| 7:40 pm - 7:50 pm | Opening Remarks |
| 7:50 pm - 8:25 pm | Farshid Guilak (Washington University in St. Louis, USA)
"Engineering New Biologic Therapies for Arthritis" |
| 8:25 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:15 pm | Thomas Clemens (Johns Hopkins University, USA)
"Role of Sensory Nerves in Skeletal Development and Repair" |
| 9:15 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Growth and Development |
| This session will highlight the latest advances
in musculoskeletal developmental biology across tissue types. In this session,
we will define and discuss the most important advances in this discipline over
the last several years. Dr. Ronen Schweitzer (OHSU), our GRS Keynote Speaker,
will serve as discussion leader. |
| Discussion Leader: Ronen Schweitzer (Shriners Research Center, Portland, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | Gabrielle Kardon (University of Utah, USA)
"Of Mice and Men: The Role of Tbx3 in Development of a Subset of Forelimb Bones, Muscles and Their Attachment Sites" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Jenna Galloway (Harvard Medical School, USA)
"Tendon Development and Regeneration: Gaining New Insights from the Zebrafish" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:30 am | Thomas Lozito (University of Pittsburgh, USA)
"Cellular Origins of Regenerated Lizard Tail Musculoskeletal Tissues" |
| 10:30 am - 10:35 am | Discussion |
| 10:35 am - 11:05 am | Coffee Break |
| 11:05 am - 11:30 am | Yingzi Yang (Harvard School of Dental Medicine, USA)
"Gas Signaling Inhibits Bone Formation in Soft Tissues by Suppressing Hedgehog Signaling" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Elazar Zelzer (Weizmann Institute of Science, Israel)
"Monosynaptic Stretch Reflex Circuit Masterminds Skeletal Regeneration and Homeostasis" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Jessica Lehoczky (Brigham and Women's Hospital, USA)
"Lgr6 Marks Nail Stem Cells and Is Required for Digit Tip Regeneration" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Multi-Scale Tissue Structure and Function |
| This session will highlight the latest advances
in multi-scale tissue structure and function, to specifically delve into how
our basic understanding is informed by studies that transit from the
macro-scale to the nano-scale, and to discuss how this new understanding
informs both basic and clinical science.
Dr. Dawn Elliott (University of Delaware) will serve as discussion
leader. |
| Discussion Leader: Dawn Elliott (University of Delaware, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:55 pm | Silvia Salinas Blemker (University of Virginia, USA)
"Multi-Scale Modeling of Skeletal Muscle Structure and Function with Application to Muscle Disease" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Karl Kadler (University of Manchester, United Kingdom)
"Circadian Clock Regulation of the Major Systems Controlling Matrix Protein Secretion and Turnover" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Alan Grodzinsky (Massachusetts Institute of Technology, USA)
"Aggrecan Nanomechanics: Relevance to Cartilage Function and Drug Delivery in PTOA" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Malin Hammerman (Linköping University, Sweden)
"Mechanical Loading Stimulates Early Tendon Healing in Rats via Microdamage" |
| 9:25 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Endogenous Stem Cells and Their Microenvironment |
| This session will identify what precisely
defines the microenvironment and what inputs regulate its modulation during
development and in disease processes. We will also discuss endogenous stem
cells within these microenvironmental niches, and their role in tissue
homeostasis, regeneration, and repair. Dr. Johnny Huard (Steadman Philippon Research Institute/University of Texas Health Science Center at Houston) will serve as discussion leader. |
| Discussion Leader: Johnny Huard (University of Texas Health Science Center, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | Benjamin Alman (Duke University, USA)
"The Rejuvenation of Fracture Repair: It's All in the Blood" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Christopher Evans (Mayo Clinic, USA)
"Genetic Modification of Endogenous Stem Cells Within Their Microenvironment" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 10:40 am | Foteini Mourkioti (University of Pennsylvania, USA)
"Stem Cell Regulation in Muscular Dystrophy" |
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 11:15 am | Coffee Break |
| 11:15 am - 11:40 am | Bruno Peault (University of California, USA / University of Edinburgh, United Kingdom)
"A Hierarchy of Innate Mesenchymal Stem Cells Within Blood Vessel Walls" |
| 11:40 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Guak Kim Tan (Shriners Hospitals for Children, USA)
"Stem/Progenitor Cell Recruitment to Deteriorating Tendons in Mice with Conditional Deletion of TGF-Beta Type II Receptor" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:30 pm | Poster Previews |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Molecular Tools to Manipulate the Cellular Program |
| Advances in both basic science knowledge and
development of new treatment paradigms require the incorporation of
cutting-edge technology. The goal of this session will be to discuss and
introduce new tools to measure and manipulate the cellular program to map and
direct cell fate (reprogramming) and to tune function (CRISPR/Cas technologies)
in the context of musculoskeletal regeneration and repair. Dr. Matt Warman (Harvard University) will
serve as discussion leader. |
| Discussion Leader: Matthew Warman (Boston Children's Hospital, Harvard University, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:55 pm | Charles Gersbach (Duke University, USA)
"Genome and Epigenome Editing for Gene Therapy and Functional Genomics" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | April Craft (Boston Children's Hospital, Harvard University, USA)
"Directed Differentiation of Human Pluripotent Stem Cells into Functionally Distinct Articular and Growth Plate-Like Cartilage Tissues" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Andres Garcia (Georgia Institute of Technology, USA)
"Biofunctional Hydrogels for Bone Repair" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Ambika Bajpayee (Langer Lab, Massachusetts Institute of Technology, USA)
"Sustained Intra-Articular Delivery of Corticosteroids Using Avidin, a Cationic Protein, as a Drug Carrier to Prevent Post-Traumatic Osteoarthritis" |
| 9:25 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Materials to Construct the Microenvironment |
| In addition to technologies focused on the
cellular program, it is essential to innovate in the development of artificial
microenvironments and tissue equivalents to probe regeneration and disease
processes. This session will focus on novel construction methods to create and
modify the cellular microenvironment, including novel material and mechanical
designs that approximate normal tissue physiology and pathophysiology. Dr.
Jason Burdick (University of Pennsylvania) will serve as discussion leader. |
| Discussion Leader: Jason Burdick (University of Pennsylvania, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | David Kaplan (Tufts University, USA)
"Tissue Engineering - A Look to the Future" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Stephanie Bryant (University of Colorado, USA)
"A Combined Experimental and Computational Approach to Designing Personalized Hydrogels" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:30 am | Brendan Harley (University of Illinois at Urbana-Champaign, USA)
"Composite Biomaterials for Craniofacial and Osteotendinous Repair" |
| 10:30 am - 10:35 am | Discussion |
| 10:35 am - 11:05 am | Coffee Break |
| 11:05 am - 11:30 am | Daniel Kelly (Trinity College Dublin, Ireland)
"Engineering the Microenvironment for Bone and Joint Regeneration" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Molly Stevens (Imperial College London, United Kingdom)
"New Biomaterials Approaches for Bone and Cartilage Repair" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Amy McNulty (Duke University Medical Center, USA)
"Characterization of Meniscus Derived Matrix and Evaluation for Repair of the Meniscus" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Multi-Scale Mechanobiology in Health and Disease |
| It is well appreciated that mechanobiology is
central to both normal tissue growth and development as well as to multiple
disease processes across the musculoskeletal system. The goal of this session
is to identify and discuss recent advances in our understanding of the
mechanisms by which cells sense mechanical perturbations and the role of
altered sensation in pathologic scenarios, as well as the application of this
knowledge towards the treatment of disease. Dr. Tamara Alliston (UCSF) will
serve as discussion leader. |
| Discussion Leader: Tamara Alliston (University of California, San Francisco, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:55 pm | Boris Hinz (University of Toronto, Canada)
"Don't Stress - The Mechanobiology of Tissue Repair" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Jan Lammerding (Cornell University, USA)
"Using Microfluidics Microfabrication to Study Nuclear Mechanics and Mechanotransduction" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Viola Vogel (ETH Zurich, Switzerland)
"From the Extracellular Matrix to the Nucleus" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Brian Cosgrove (University of Pennsylvania, USA)
"N-Cadherin Adhesive Interactions Modulate ECM Mechanosensing and Fate Commitment in Mesenchymal Stem Cells" |
| 9:25 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Model Systems to Study MSK Injury, Repair, and Regeneration |
| The transition to translation begins with model
systems. These may start as a simple
system in which to test a new therapy in a surgical model, but ultimately need
to be realized in the context of complex and often pathologic scenarios. In this session, we will discuss current
models of musculoskeletal tissue injury, repair, and regeneration and identify
commonalities in study design that enable the more faithful recapitulation of
the scenario in which repair occurs so as to increase the probability of
clinical translation. Dr. Chungfeng Zhao (Mayo Clinic) will serve as discussion
leader. |
| Discussion Leader: Chunfeng Zhao (Mayo Clinic, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | Amy Wagers (Harvard University, USA)
"Targeting Muscle Stem Cells for Regenerative Medicine" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Hani Awad (University of Rochester, USA)
"Manipulating Protease Activity for Scarless Flexor Tendon Healing in Mice" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:30 am | Alice Huang (Icahn School of Medicine at Mount Sinai, USA)
"Regulation of Tendon Regeneration and Scar Formation" |
| 10:30 am - 10:35 am | Discussion |
| 10:35 am - 11:05 am | Coffee Break |
| 11:05 am - 11:30 am | Kurt Hankenson (Michigan State University, USA)
"The Essential Role of Vascularization During Bone Regeneration: Animal and Computational Models" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Fergal O'Brien (Royal College of Surgeons in Ireland, Ireland)
"Natural Polymer-Based Scaffolds as Platform Systems for the Delivery of Therapeutics to Promote Enhanced Bone, Cartilage and Osteochondral Tissue Repair" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Kyle Allen (University of Florida, USA)
"Magnetic Capture of Osteoarthritis Biomarkers in the Rat" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Confounders of Regeneration: Aging, Inflammation, Fibrosis, and Other
Factors |
| While in the previous session we discussed
models of musculoskeletal repair, this session will turn its attention to
systemic matters, and how these broader factors impact the process of tissue
injury, repair, and regeneration. This
will include inputs from not just multiple interacting musculoskeletal tissues,
but also multiple organ systems that impact disease progression and repair
potential. To end the conference, we will particularly focus here on studies
that are by their very nature multi-disciplinary, crossing numerous tissue
types and organ systems to provide a wider perspective on musculoskeletal
biology, bioengineering, repair, and regeneration. Dr. Nadeen Chahine
(Feinstein Institute) will serve as discussion leader. |
| Discussion Leader: Nadeen Chahine (The Feinstein Institute for Medical Research, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 8:00 pm | James Iatridis (Icahn School of Medicine at Mount Sinai, USA)
"Injury, Inflammation, and Altered Mechanotransduction in the Intervertebral Disc" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Beth Winkelstein (University of Pennsylvania, USA)
"Moving (or Removing) the Needle for Improved Pain Treatments" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Brian Diekman (University of North Carolina at Chapel Hill, USA)
"Transcriptional Regulation of the Aging
Biomarker p16INK4a and its Role in Mediating Chondrocyte Senescence During
Osteoarthritis" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Christopher Hernandez (Cornell University, USA)
"Disruption of the Gut Microbiome Impairs Bone
Strength and Tissue Material Properties in Mice" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Closing Remarks |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
