Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Biological Genesis of Motion
Discussion Leader: Kim Cooper (University of California, San Diego, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Otger Campas (University of California, Santa Barbara, USA)
"How Is Integrated Tissue Architecture Established? Lessons from Body Axis Elongation in Vertebrates"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Marian Ros (Instituto de Biomedicina y Biotecnología de Cantabria, CSIC, Spain)
"Hox Genes Distinguish Long from Short Bones: Origins of the Wrist and Ankle"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Ralph Marcucio (University of California, San Francisco, USA)
"Movements in Morphospace: How Are Shape and Variation Generated in the Embryonic Face?"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Energetics and Control
Discussion Leader: Clifford Rosen (Maine Medical Center Research Institute, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Bruce Spiegelman (Dana-Farber Cancer Institute / Harvard Medical School, USA)
"Muscle Signaling to Other Tissues: Bone and Beyond"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Fanxin Long (Washington University School of Medicine, USA)
"Metabolic Regulation of Skeletal Cells"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Anne Gingery (Mayo Clinic, USA)
"Cellular Senescence in Carpal Tunnel Syndrome: Restoring Function and Mobility"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Jennifer Elisseeff (Johns Hopkins University, USA)
"Implications of Cell Senescence for the Aging Skeleton"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Stavroula Kousteni (Columbia University, USA)
"Bone and Brain Communications: Regulation of Appetite"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Dominique Muschter (University Hospital Regensburg, Germany)
"Sensory Nervous System Impact on Subchondral Bone Pathology in a Murine OA Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Jennifer Elisseeff (Johns Hopkins University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Organization and Behavior
Discussion Leader: Kacey Marra (University of Pittsburgh, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Vicki Rosen (Harvard School of Dental Medicine, USA)
"Meniscus Morphogenesis: Development in Motion"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Brian Johnstone (Oregon Health & Science University, USA)
"Making Cartilage: Lessons (Not) Learned"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
David Hoey (Trinity College, Dublin, Ireland)
"Skeletal Stem Cell Contributions to the Mechanoadaptation of Bone: Direct and Indirect Biophysical Regulation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Macrostructural Musculoskeletal Elements
Discussion Leader: Michael Yaszemski (Mayo Clinic, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
X. Sherry Liu (University of Pennsylvania, USA)
"Functional Adaptation of the Maternal Skeleton to Pregnancy and Lactation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Tammy Haut Donahue (University of Massachusetts Amherst, USA)
"Menisci and Their Ligamentous Attachments in Health and Disease"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Brett Klosterhoff (Georgia Institute of Technology, USA)
"Quantifying the Mechanical Environment Throughout Bone Repair: An Implantable Strain Sensor Platform for Non-Invasive Monitoring"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Michael Yaszemski (Mayo Clinic, USA), Richard Lieber (Shirley Ryan AbilityLab, USA) and Benjamin Wheatley (Bucknell University, USA)
"Muscle Force Production Across the Agespan"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Makarand Risbud (Thomas Jefferson University, USA)
"Insights into Mechanisms Underlying Spontaneous, Early Onset Intervertebral Disc Degeneration"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Central and Peripheral Neurological Control Systems
Discussion Leader: Susanne Graessel (University of Regensburg, Germany)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Florent Elefteriou (Baylor College of Medicine, USA)
"Autonomic Regulation of Bone Remodeling"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Paul Baldock (Garvan Institute of Medical Research, Australia)
"Neuropeptide Regulation of Skeletal and Muscular Responses to Altered Energy Balance"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Jason McDougall (Dalhousie University, Canada)
"Peripheral Mechanisms of Joint Nociception"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diseases of Mobility
Discussion Leader: Frank Beier (University of Western Ontario, Canada)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Christopher Little (University of Sydney, Australia)
"How Does Joint Injury Lead to Osteoarthritis, Dysfunction and Disability?"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Cheryle Seguin (University of Western Ontario, Canada)
"Ectopic Calcification of the Spine: The What, Where and Why of Diffuse Idiopathic Skeletal Hyperostosis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Megan Killian (University of Delaware, USA)
"Lifting the Breaks on Bone Shape"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Theresa Guise (Indiana University, USA)
"Role of Bone-Derived TGF-Beta on Muscle Function and Glucose Metabolism"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Teresita Bellido (Indiana University School of Medicine, USA)
"Atrogenes as Common Mediators of Glucocorticoid-Induced Bone and Muscle Atrophy and Weakness"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Alesha Castillo (New York University, USA)
"Targeting Osteogenesis-Angiogenesis Coupling for Bone Repair"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
The Restoration of Musculoskeletal Function
Discussion Leader: Louis Defrate (Duke University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Martha Murray (Boston Children's Hospital, USA)
"Bridge-Enhanced ACL Repair: From Concept to Clinical Trial"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Robert Guldberg (Georgia Institute of Technology, USA)
"Functional Restoration Following Complex Musculoskeletal Trauma"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Gregory Sawicki (Georgia Institute of Technology, USA)
"Biologically Inspired Concepts Guiding Lower-Limb Exoskeleton Design"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Perfecting Musculoskeletal Coordination
Discussion Leader: L. Scott Levin (University of Pennsylvania, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Robert Mauck (University of Pennsylvania, USA)
"Perfecting Cellular Motion, Promoting Repair"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Paul Cederna (University of Michigan, USA)
"Use of Regenerative Peripheral Nerve Interfaces for Closed Loop Neural Control of Prosthetics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Sarah Gullbrand (University of Pennsylvania, USA)
"Functional Integration of a Tissue Engineered Intervertebral Disc and Translation to a Large Animal Model"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Laurie Goodrich (Colorado State University, USA)
"A Gene Therapeutic Approach to Inhibiting Articular Inflammation and Restoring Joint Function"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Richard Lieber (Shirley Ryan AbilityLab, USA)
"Biological and Biomechanical Studies of Human Muscle Contractures"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kenneth Weekes (Oregon Health & Science University, USA)
"Reconsidering the Origin of the TMJ Articular Disc"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Musculoskeletal System and the Machine
Discussion Leader: Peter Johnson (MedSurgPI, LLC, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:45 pm
Dean Kamen (DEKA Research and Development Corporation, USA)
"Wounded Warfighters Deserve More than a Hook on the End of a Stick: Moving Toward Restoring Form and Function"
8:45 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure