Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Biology and Bioengineering as a Platform for Change
Discussion Leader: Constance Chu (Stanford University, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
Kelly Stevens (University of Washington, United States)
"Synthetic Biology in the Construction and Control of Artificial Tissues"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Antentor Hinton (Vanderbilt University, United States)
"Using Structural Changes in Mitochondrial Aging to Create a Thriving Laboratory Culture."
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Eva González Díaz (Stanford University, United States)
"Spatially Patterned, 3D In Vitro Models of Cancer Metastasis to Bone for Elucidating Key Drivers of Metastasis and Drug Discovery"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biology and Bioengineering of Aging in the Musculoskeletal System
Discussion Leader: Peter Amadio (Mayo Clinic, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Sarah Dallas (University of Missouri Kansas City, United States)
"Cellular Dynamics in Bone Development and Aging"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Brian Diekman (Univ North Carolina / NC State, United States)
"Accumulated DNA Damage in Chondrocytes is Reduced by Activation of Sirtuin 6"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jin Han (Johns Hopkins University, United States)
"Engineering Immune-Modulatory Regenerative Medicine in Aging"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Brianne Connizzo (Boston University, United States)
"Altered Inflammatory Responses with Aging in an In Vitro Bone-Tendon-Muscle Model"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
Adetola Adesida (University of Alberta, Canada)
"Revisiting Isolation of Meniscus Cells for Tissue Engineering"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Kharma Foucher (University of Illinois at Chicago, United States)
"Can We Reverse the Effects of Osteoarthritis on Aging Muscle?"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Courtney Edwards (Vanderbilt University, United States) and Helen Lu (Columbia University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Musculoskeletal Pain: Causes and Cures
Discussion Leader: Anne-Marie Malfait (Rush University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Tony Yaksh (UCSD, United States)
"General Principles in Pain Processing: Application to problems in Musculoskeletal Pain"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
A. Vania Apkarian (Northwestern University, United States)
"Pre-surgical Brain Properties Predicting Pain Persistence Following Total Knee Replacement Surgery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Deepak Kumar (Boston University, United States)
"Exercise and Musculoskeletal Pain"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Spatial Context in the Musculoskeletal System
This session will explore the role of spatial control and context in the biological and physical function of the musculoskeletal system using novel bioengineering and imaging approaches.
Discussion Leader: Catherine Kuo (University of Maryland, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Lin Han (Drexel University, United States)
"Rapid Evolvement and Specialization of the Primitive Matrix in Embryonic Cartilage at the Nanoscale"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Ralph Müller (ETH Zurich, Switzerland)
"Multiscale Quantification of Spatial Bone Mechanobiology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Callan Luetkemeyer (University of Colorado Boulder, United States)
"Defining Mechanical Thresholds for Collagen Microdamage in Soft Musculoskeletal Tissues"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Peter Croucher (Garvan Institute of Medical Research, Australia)
"Spatial Analysis of the Endosteal Niche"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Stefano Di Talia (Duke University, United States)
"Waves, Flows and Gradients in Zebrafish Bone Regeneration"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Braden Fleming (Rhode Island Hospital/Brown University, United States)
"Predicting Anterior Cruciate Ligament (ACL) Failure Load with MRI and Machine Learning as a Prospective Imaging Biomarker for Revision Surgery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tracking Musculoskeletal Histories Over Time
Discussion Leader: Ivo Kalajzic (University of Connecticut Health Center, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
George Muschler (Cleveland Clinic Foundation, United States)
"Practical Tools for Management of Progenitor Cell Heterogeneity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Qing-Jun Meng (University of Manchester, United Kingdom)
"Circadian Rhythms in Health and Disease of the Musculoskeletal System"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Terence Capellini (Harvard University, United States)
"Investigating the Regulatory Control of Human Skeletal Development, Evolution, and Disease Risk"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Multiscale Metabolism in Musculoskeletal Tissue Crosstalk
Discussion Leaders: Blaine Christiansen (University of California Davis, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Tri Phan (Garvan Institute of Medical Research, Australia)
"Metabolic Control of Osteoclast Recycling and Osteomorph Formation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Ronald June (Montana State University, United States)
"Understanding Joint Homeostasis and Pathophysiology Using Metabolomic Profiling"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Kelsey Collins (Washington University in St. Louis, United States)
"Leptin Regulates Fat-Cartilage Crosstalk in Osteoarthritis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Graham Williams (Imperial College London, United Kingdom)
"Role of CNS Regulatory Genes in Skeletal Development and Bone Maintenance"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Nancy Lane (University of California, Davis, United States)
"Brain Derived Osteogenic Factor: A Brain and Bone Connection"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sanique South (Oklahoma Medical Research Foundation, United States)
"Sex Specific Mediators of PTOA Pain and Inflammation in Adult Mice"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Enlisting the Immune System for Musculoskeletal Health
Discussion Leader: Laura McCabe (Michigan State University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Dana Graves (University of Pennsylvania, United States)
"Immune-Modulatory Role of Prx1+ Mesenchymal Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Danièle Noël (French National Institute of Health and Medical Research, France)
"Mesenchymal Stromal Cell-derived Extracellular Vesicles for Targeting Inflammation and Senescence in Osteoarthritis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Gabriel Mbalaviele (Washington University School of Medicine in St. Louis, United States)
"Macrophage-Osteoclast Lineage Autonomously Dials Down Inflammasome Pathways to Survive"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Multiscale Musculoskeletal Mechanobiology
Discussion Leader: Pen-Hsiu Chao (National Taiwan University, Taiwan)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Alayna Loiselle (University of Rochester, United States)
"Multiscale Definition of Pro-fibrotic Regulation of Tendon Healing"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Melissa Knothe Tate (Blue Mountains World Interdisciplinary Innovation Institute, Australia)
"Using Innovative Biotech to Test, Probe, and Prioritize Hypotheses - Case Studies in Multiscale Mechanobiology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Sungmin Nam (Harvard University, United States)
"Tissue-Interfacing Automatic Stimulation Devices for Muscle Regeneration & Rehabilitation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Niamh Nowlan (University College Dublin, Ireland)
"Multiscale Mechanobiology of Cartilage Morphogenesis: How Collective Cell Behaviours Determine Joint Shape Under Normal and Abnormal Loading"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Angus Wann (Kennedy Institute, University of Oxford, United Kingdom)
"A Cartilaginous Mechanostat"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Hae Lin Jang (Brigham and Women's Hospital, Harvard Medical School, United States)
"Osteocytes with a 3D Dendritic Network in Engineered Bone Tissue on a Chip"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Musculoskeletal Biology and Biomaterial
Discussion Leader: Alan Grodzinsky (Massachusetts Institute of Technology, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Robert Bowles (University of Utah, United States)
"CRISPR for Discovery, Design, and Development of Musculoskeletal Therapeutics"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Blanka Sharma (University of Florida, United States)
"Engineering Biomaterials for Targeted Therapeutic Delivery in the Joint"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Johnna Temenoff (Georgia Tech/Emory, United States)
"Biomaterials for Expansion of Potent Mesenchymal Stromal Cells for Musculoskeletal Repair"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
