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Session 1 evening Sunday, Feb 27
Topic: New techniques to study mutations, DNA damage and DNA repair and mutagenesis
- Introduction: John Essigmann M.I.T.
- Eric Kool Stanford University - Novel DNA bases to study the mechanism of lesion bypass
- Rudolf Rigler Karolinska Institutet - Single molecule DNA sequencing
- Final Discussion: Ed Loechler City of Hope Hospital
Session 2 morning Monday, Feb 28
Topic: NMR structural studies
- Introduction: Nick Geacintov New York University
- Dinshaw Patel Memorial Sloan-Kettering Cancer Center - NMR studies of carcinogen adducts
- Al Mildvan Johns Hopkins University - Solution structure and mechanism of the MutT enzyme
- Final Discussion: Suse Broyde New York University
- Remembering Tony Dipple: Bob Moschel
Session 3 evening Monday, Feb 28
Topic: From carcinogens to mutation
- Introduction: Lawrence Marnett Vanderbilt University
- John Hays Oregon State University - Mismatch-repair processing of damaged DNA
- Gerd Pfeifer City of Hope Hospital - Adduct hotspots and repair rates relevant to cancer
- Chris Lawrence Rochester University - The role of DNA polymerase Zeta in Induced Mutagenesis
- Final Discussion: Bea Singer University of California, Berkeley
Session 4 morning Tuesday, Feb 29
Topic: Relationship between DNA adducts and mutation
- Introduction: Robert Moschel NCI-Frederick Cancer Research Center
- Arthur Grollman State University of New York, Stony Brook - Is Tamoxifen a Human Carcinogen?
- Ed Loechler Boston University - Benzo[a]pyrene Mutagenic Mechanisms
- Frederick Guengerich Vanderbilt University
- Michael Stone Vanderbilt University
- Final Discussion: Bea Singer University of California, Berkeley
1:30 - 2:30 Informal Discussions
- Thomas Spratt - Adducts to mutations
- Takehiko Nohmi - Assays, spectra, animal studies
Session 5 evening Tuesday, Feb 29
Topic: DNA Polymerases
- Introduction: Sam Wilson NIEHS
- Catherine Joyce Yale University
- Lawrence Loeb University of Washington
- Final Discussion: Thomas Kunkel NIEHS
Session 6 morning Wednesday, Mar 1
Topic: DNA Polymerase and Lesion Bypass
- Introduction: Steven Benkovic Pennsylvania State University
- Myron Goodman University of Southern California
- Fumio Hanaoka Osaka University
- Louise Prakash University of Texas, Galveston - New DNA polyemrases in eukaryotic cells involved in the bypass of damaged DNA templates
- Final Discussion: Samuel Wilson NIEHS
Informal Discussions
- Kristen Eckert - DNA Polymerases
- Gerald Holmquist - DNA Repair
Session 7 evening Wednesday, Mar 1
Topic: Mutator Phenotypes
- Introduction: Manuel Perucho Burnham Institute - The microsatellite mutator phenotype
- Brad Preston University of Utah - Mutator Alleles Affecting Polymerase Fidelity in Mice
- Curtis Harris National Cancer Institute - p53 in human cancer
- Final Discussion: Lawrence Loeb
Session 8 morning Thursday, Mar 2
Topic: Gene Regulation in Carcinogenesis: Non-Genotoxic Events
- Introduction: Nancy Colburn NCI-Frederick Cancer Research Center - Transcriptional Events in Tumor Promotion: Requirement for AP-1 transactivation
- Cyrus Vaziri Boston University Medical School - Aryl-Hydrocarbon-Induced Cell Cycle Checkpoints
- Stephen Baylin Johns Hopkins University - Tumor suppressor genes regulated by methylation at CpG islands
- Selected Short Presentations
Session 9 evening Thursday Mar 2
Topic: Genetic Susceptibility and Cancer
- Introduction: Lawrence Grossman Johns Hopkins University
- Ray Monnat University of Washington - Werner's Syndrome
- Discussion: Bradley Preston Utah University
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