| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | The Role of Mutagenesis in Carcinogenesis |
| Discussion Leader - Larry Marnett, Vanderbilt University |
| Larry Marnett, Vanderbilt University
"Welcome and Overview of Conference" |
| Rick Boland, Baylor Dallas
"Genetics of Colon Cancer" |
| Veronica Maher, Michigan State University
"Relative Contribution of Translesion Synthesis and Use of an Undamaged Homologous Copy of a Gene in Human Cells Dealing with Fork-Blocking Lesions"
|
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:50 am - 12:30 pm | DNA Damage - Novel Lesions - Occurrence and Mutagenesis |
| Discussion Leader - Larry Sowers, Loma Linda Universitry |
| Cindy Burrows, University of Utah
"Novel Oxidative Lesions" |
| Jim Swenberg, University of North Carolina
"Exocyclic Adducts" |
| 10:00 am | Group Photo / Coffee Break |
| 10:40 am | Questions and Answers |
| Jay Heinecke, University of Washington
"Halogenated Lesions from Inflammation" |
| Larry Marnett, Vanderbilt University
"DNA-Catalyzed Interconversion of Malondialdehyde-Deoxyguanosine Adducts and Its Implications for Mutagenesis" |
| 12:30 pm | Lunch |
| |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Translesion Synthesis and Damage Avoidance In Vivo |
| Discussion Leader - Ellen Fanning, Vanderbilt University |
| Robert Fuchs, CNRS, Strasbourg
"Leading and Lagging Strand Synthesis In Vivo" |
| Teresa Wang, Stanford
"Checkpoint Activation and Translesion Synthesis" |
| Justin Courcelle, Mississippi State
"DNA Damage and Replication Fork Progression" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Replication Complex - Lesion Interactions |
| Discussion Leader - Ed Loechler, Boston University |
| Masaaki Moriya, SUNY Stonybrook
"Mechanistic Analysis of Translesion Synthesis Across Endogeneous Exocyclic DNA Adducts in Human Cells"
|
| Roger Woodgate, NICHD
"Lesion Bypass In Vitro" |
| 10:30 am - 11:00 am | Coffee |
| Tom Ellenberger, Harvard
"Structure of Replication Complexes" |
| Myron Goodman, University of Southern California
"Somatic Hypermutation Targeted by AID, Activation-Induced Cytidine Deaminase" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Replication Complex - Lesion Interactions |
| Discussion Leader - Robert Fuchs, CNRS, Strasbourg |
| Hisaji Maki, Nara Institute of Science and Technology
"Structure of the Replication Fork in the Presence of Lesions" |
| Alan Lehmann, University of Sussex
"Postranslational Modifications in the Switch from Replicative to Translesion Synthesis" |
| Achille Pellicioli, University of Milan
"Accumulation of Replication Intermediates with Checkpoint Mutations" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cross-link-Induced Mutagenesis |
| Discussion Leader - Erik Radany, University of California, Irvine |
| Tom Harris, Vanderbilt University
"Interstrand Cross-links from Endogenous Aldehydes" |
| Maria Tomacz, Hunter College
"Relation of Structure to Mutagenesis and Cell Killing by Mitomycin C" |
| 10:30 am - 11:00 am | Coffee |
| Randy Legerski, M.D. Anderson
"Site-Specific Mutagenesis by DNA Interstrand Cross-links" |
| Jan Hoeijmakers, Erasmus University
"Genetics of Cross-link Repair and Mutagenesis - The Role of Nucleotide Excision Repair" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Chromosomal Translocations |
| Discussion Leader - Mike Cox, University of Wisconsin |
| Fred Alt, Harvard Medical School
"Mechanisms of Chromosomal Translocations" |
| Bevin Engleward, MIT
"Recombination Induced by DNA Damage" |
| John Tainer, Scripps
"Structure of the RAD50/MRE11 Complex" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA Damage/Mutation and Cell Signaling |
| Discussion Leader - Rick Boland, Baylor, Dallas |
| Aziz Sancar, University of North Carolina
"Binding of ATR to Damaged DNA" |
| Paolo Plevani, Universita Degli Studi di Milano
"Physical and functional interactions
between the DNA damage checkpoint and DNA repair" |
| 10:30 am - 11:00 am | Coffee |
| John Diffley, Cancer Research Campaign
"Stalled Replication Forks and Checkpoint Control" |
| Charles Sawyers, UCLA
"Mutations Relevant to the Cause and Treatment of Chronic Myelogenous Leukemia" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm | Bea Singer Award / Executive Session |
| 7:30 pm - 9:30 pm | Mutagenesis and Carcinogenesis |
| Discussion Leader - Larry Loeb, University of Washington |
| George Bailey, Oregon State University
"Dose-Response for DNA Damage, Cell Proliferation, and Carcinogenesis by dibenzo(a,l)pyrene" |
| Junjian Chen, National Center for Toxicological Research
"Multiple Mitochondrial Mutations in Prostate Cancer" |
| Keiji Wakabayashi, National Cancer Center Japan
"ADP Ribosylation of DNA and Mutagenesis by Pierisin-1" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
