Sunday, Evening |
DNA Polymerase Structure/Function |
Chair: Thomas Kunkel, NIEHS
Discussion Leader: Linda Reha-Krantz, University of Alberta
- Sylvie Doublié, Harvard Medical School - Caught in the act: crystal structure of the T7 replication complex
- Lorena Beese, Duke University - Observing replication and mutagenesis in a catalytically active DNA polymerase crystal
- William Konigsberg, Yale University - DNA polymerase-substrate encounters of the third kind: Effect of ribonucleotide residues on excision rates when DNA polymerases are in the editing mode
Monday, Morning |
DNA Polymerase Fidelity/Lesion Bypass |
Chair: Myron Goodman, University of Southern California
Discussion Leader: Arthur Grollman, SUNY Stony Brook
- Michael O'Donnell, Rockefeller University - Inner workings of the machine that assembles polymerase clamps onto DNA
- Joann Sweasy, Yale University School of Medicine - Fidelity mutants of DNA polymerase beta
- Eric Kool, University of Rochester - How important are hydrogen bonds in replication and mutagenesis?
Monday, Evening |
Mismatch Repair |
Chair: Paul Modrich, Duke University
Discussion Leader: Josef Jiricny, University of Zürich
- Paul Modrich - Mechanisms of mismatch repair in E. coli and human cells
- Richard Kolodner, Ludwig Institute for Cancer Research at UC - San Diego - Multiple mehanisms of mutation suppression
- Andrew Buermeyer, Oregon Health Sciences Center - Role of Mammalian MutL Homologs in DNA Mismatch Repair
Tuesday, Morning |
Endogenous Damage: Repair |
Chair: Richard Cunningham, SUNY - Albany
Discussion Leader: Leona Samson, Harvard School of Public Health
- John Tainer, Scripps Research Institute - Initation Steps of Base-Excision Repair Revealed by Enzyme-DNA Co-crystal Structures
- Gregory Verdine, Harvard University - Mechanistic and Structural Studies on Repair of Damaged DNA Bases
- Samuel Wilson, NIEHS - Rate-limiting steps during base excision repair of endogeneous DNA lesions
Tuesday, Evening |
Endogenous Damage: Global Responses and Mutagenesis |
Chair: Bernard Weiss, University of Michigan
Discussion Leader: Lawrence Loeb, University of Washington
- Bruce Demple, Harvard School of Public Health - Oxidative stress responses and the prevention of genetic damage
- Shoshy Altuvia, Hebrew University - Bacterial response to oxidative stress: Role of a small RNA as a global regulator and antimutator
- Miroslav Radman, Institut Jacques Monod - Oxidative damage cuases high error rates of DNA replication and transcription/translation processes in aging bacterial colonies
Wednesday, Morning |
Homologous Recombination |
Chair: Steven West, ICRF
Discussion Leader: Sue Jinks-Robertson, Emory University
- Scott Morrical, University of Vermont - Recombinase and Helicase Loading Mechanisms in T4 Recombination
- Patrick Sung, University of Texas - Enzymology of Heteroduplex DNA Formation
- Junjie Chen, Dana Farber Cancer Institute - Breast Cancer Susceptibility genes and DNA repair
Wednesday, Evening |
Non-homologous Recombination and Double Strand Break Repair |
Chair: Stephen Jackson, Wellcome/CRC
Discussion Leader: Susan Lees-Miller, University of Calgary
- Steve Jackson - The detection, signalling and repair of DNA double-strand
breaks
- Nancy Kleckner, Harvard University - IHF modulation of Tn10/IS10 transposition in vitro and in vivo: Sensory transduction of supercoiling status via a proposed
protein/DNA molecular spring
- James Haber, Brandeis University - Expansions and contractions of repeated sequences induced during gene conversion repair of double-strand breaks
Thursday, Morning |
Interrelationships Among Repair Pathways and Cell Cycle |
Chair and Discussion Leader: Philip Hanawalt, Stanford University
- Priscilla Cooper, University of California, Berkeley - Intersection of Base and Nucleotide Excision Pathways in Transcription-Coupled Repair of Oxidative Damage
- Frank Jirik, University of British Columbia - Lymphomas arising from the thymi of mismatch repair-deficient mice show hypermutation of a lacI transgenic reporter
- Graham Walker, MIT - Inducible E. coli proteins involved in mutagenesis and
control of cell cycle in response to DNA damage
- Ted Weinert, University of Arizona - Mysteries of Checkpoint Control in Yeast
Thursday, Evening |
At Risk Sequences in the Human Genome |
Chair and Discussion Leader: Lynn Ripley, UMDNJ
- Lynn Ripley - Genomics and Spontaneous Mutation Specificity: A demonstration
that combinatorial approaches do identify novel hotspots and point to the mechanism
- Cynthia McMurray, Mayo Clinic - Mutational mechanisms for DNA instability in human disease
- Dmitry A. Gordenin, NIEHS - Yeast models of human ARMs (At-Risk Motifs)
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