| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Presentations |
| 7:30 pm - 7:50 pm | Session Chair: Phillip Hanawalt (Stanford University)
Overview |
| 7:50 pm - 8:40 pm | Mike O'Donnell (Rockefeller University)
"Mechanism of Clamps and Clamp Loaders of DNA Replicases" |
| 8:40 pm - 9:30 pm | Samuel H. Wilson (NIEHS)
"Structure and function of DNA Polymerase Beta/DNA Complexes with Mismatched Base Pairs at the Polymerase Active Site" |
| 10:00 pm - 11:30 pm | Chair's Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA Replication: Structure, Function, Accuracy |
| 9:00 am - 9:40 am | Session Chair: Linda B. Bloom (University of Florida)
"A DNA-Triggered Switch for Modulating Clamp Loader Interactions with DNA and the Clamp" |
| 9:40 am - 10:15 am | Thomas A. Kunkel (NIEHS)
"Long Distance Control of Replication Fidelity by Origins in Yeast" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:20 am | Eric T. Kool (Stanford University)
"DNA Base Mimics as Probes of Replication and Repair Mechanisms" |
| 11:20 am - 11:55 am | Ming-Daw Tsai (Ohio State University)
"A Simplified Model for the Fidelity of DNA Polymerases" |
| 11:55 am - 12:30 pm | Kenneth A. Johnson (University of Texas, Austin)
"Selectivity of the Mitochondrial DNA Polymerase and the Toxicity of Nucleoside Analogs Used to Treat AIDS" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Structural, Kinetic and Theoretical Determinants of DNA Polymerase Fidelity |
| 7:30 pm - 8:00 pm | Session Chair: Joann Sweasy (Yale University)
"Fidelity Mechanisms of DNA Polymerase Beta Governed by Amino Acid Residues Distant From the Active Site" |
| 8:00 pm - 8:30 pm | Wei Yang (NIH)
"Lesion Bypass by S sol Dpo4" |
| 8:30 pm - 9:00 pm | Arieh Warshel (University of Southern California)
"General Factors in Enzyme Catalysis and their Specific Contributions to the Fidelity of DNA Polymerases" |
| 9:00pm - 9:30 pm | Discussion Leader: Thomas Ellenberger (Harvard Medical School) |
| 10:00 pm - 11:30 pm | Mixer |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Nucleotide Excision and DNA Mismatch Repair |
| 9:00 am - 9:40 am | Session Chair: Paul Modrich (Duke University)
"Mismatch Repair: Feature of Mechanism" |
| 9:40 am - 10:15 am | Richard Wood (University of Pittsburgh)
"Activities and Interactions in NER and DNA Crosslink Repair" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:15 am | Peggy Hsieh (NIH)
"Molecular Mechanisms of DNA Mismatch Repair" |
| 11:15 am -11:45 am | Jan H.J. Hoeijmakers (Erasmus University, Rotterdam)
"Nucleotide Excision and Transcription Coupled Repair: In Vivo Dynamics and Relation to Aging" |
| 11:45 am -12:30 pm | Discussion Leader: Errol C. Friedberg (Southwestern Medical School) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Base Excision Repair |
| 7:30 pm - 8:00 pm | Session Chair: John Tainer (Scripps Research Institute)
"Coordination of DNA Base Excision and Double Strand Break Repair Processes" |
| 8:00 pm - 8:30 pm | Priscilla Cooper (Lawrence Berkeley National Laboratory)
"Choreographing Base Excision Repair: Role of XPG Protein" |
| 8:30 pm - 9:00 pm | Tomas Lindahl (ICRF Clare Hall Laboratories, England)
"Reversal of Alkylation DNA Damage by Oxidative Demethylation" |
| 9:00 pm - 9:30 pm | Susan Wallace (University of Vermont)
"Processing of Oxidative DNA Base Damages" |
| 10:00 pm - 11:30 pm | Mixer |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA Recombination and Double-Strand Break Repair |
| 9:00 am - 9:40 am | Session Chair: Roland Kanaar (Erasmus University)
"Homologous Recombination Protein: Architecture and DNA Repair Dynamics" |
| 9:40 am - 10:15 am | Kerry Bloom (University of North Carolina)
"Visualization of Chromosome and Repair Protein Dynamics Following Induction of DNA Double-Strand Breaks" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:20 am | Jean Gautier (Columbia University)
"DNA Damage Response: Linking Cell Cycle Arrest, DNA Replication and DNA Repair" |
| 11:20 am - 11:55 am | Patrick Sung (U. Texas, San Antonio)
"Crosstalk Among Rad51, Rad54, and RPA in DNA Joint Formation" |
| 11:55 am - 12:30 pm | Benedicte Michel (INRA, France)
"Rescue of Arrested Replication Forks by Homologous Recombination" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:15 pm | Business Meeting |
| 7:30 pm - 9:30 pm | Synthesis by Error-Prone Polymerases |
| Session Chair: Roger Woodgate (NIH) |
| 7:30 pm - 8:00 pm | Fumio Hanaoka (Osaka University)
"Biochemical Properties of Human DNA Polymerase Eta" |
| 8:00 pm - 8:30 pm | Roger Woodgate (NIH)
"In Vivo Regulation of Pol Iota" |
| 8:30 pm - 9:00 pm | Phuong Pham (University of Southern California)
"SOS Mutagenesis Requiring Pol V and Two Non-filamentous RecA Modes of Action" |
| 10:00 pm - 11:30 pm | Mixer |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Somatic Hypermutation of Immunoglobulins |
| 9:00 am - 9:40 am | Session Chair: Nancy Maizels (University of Washington)
"DNA Break-and-Repair Mechanisms in Hypermutation" |
| 9:40 am - 10:15 am | Michael Neuberger (Cambridge University)
"Antibody Gene Diversification" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:20 am | Matthew D. Scharff (Albert Einstein Medical College)
"Regulation and Targeting of Somatic V Region Mutation" |
| 11:20 am - 11:55 am | Claude-Agnes Reynaud (Necker-Enfants Malades, France)
"Ig Gene Hypermutation in Burkitt Lymphomas" |
| 11:55 am - 12:30 pm | Ursula Storb (University of Chicago)
"Molecular Aspects of Immunoglobulin Gene Somatic Hypermutation" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Banquet |
| 7:30 pm - 9:30 pm | Mutagenesis and Genetic Instability in Evolution and Human Disease |
| 7:30 pm - 8:00 pm | Session Chair: Lawrence A. Loeb (University of Washington)
"Generators of a Mutator Phenotype" |
| 8:00 pm - 8:30 am | Norman Arnheim (University of Southern California)
"Do Mutation Frequencies Increase as Men Age?" |
| 8:30 pm - 9:00 pm | Thomas A. Cebula (US Food and Drug Administration)
"Relative Roles of Change and Exchange in Bacterial Evolution" |
| 9:00 pm - 9:30 pm | Evan Eichler (Case Western Reserve University)
"Duplication, Dynamic Mutation and the Evolution of the Human Genome" |
| 10:00 pm - 11:30 pm | Mixer |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
