SUNDAY |
2:00 pm - 9:00 pm | Arrival and check-in |
6:00 pm | Dinner |
7:30 pm - 8:30 pm | RECAPITULATING MUTATION RESEARCH |
7:30 pm - 8:30 pm | John W. Drake (NIEHS)
"A historical account of mutation research" |
8:30 pm | Chair's Opening Reception |
MONDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MUTAGENIC SYSTEMS |
9:00 am - 9:45 am | Discussion Leader: Nancy Maizels (University of Washington) "Hyper-hypermutation induced by conserved factors" |
9:45 am - 10:30 am | Claude-Agnes Reynaud (Necker-Enfants Malade, Paris)
"Error-prone DNA polymerases and hypermutation" |
10:30 am | Coffee Break |
11:00 am - 11:45 am | Simon Wain-Hobson (Institut Pasteur, Paris)
"Hyperediting of retroviral DNA as a novel arm to innate immunity" |
11:45 am - 12:30 pm | Susan Rosenberg (Baylor College of Medicine)
"Mutation as a stress response: adaptive mutation in E. coli" |
12:45 pm | Lunch / Photo |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HYPERMUTABLE SEQUENCES |
7:30 pm - 7:45 pm | Discussion Leader: Richard Moxon (John Radcliffe Hospital, Oxford) |
7:45 pm - 8:10 pm | Christopher Bayliss (John Radcliffe Hospital, Oxford)
"Bacterial microsatellites: Harnessing the power of hypermutation" |
8:10 pm - 8:50 pm | Cynthia McMurray (Mayo Clinic)
"MSH2-dependent mechanisms leading to expansion" |
8:50 pm - 9:30 pm | Thomas D. Petes (University of North Carolina)
"Genetic analysis of genome stability in yeast" |
TUESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MUTAGENIC MECHANISMS |
9:00 am - 9:45 am | Discussion Leader: Roger Woodgate (NIH)
"Modulating the activities of Y-family DNA polymerases" |
9:45 am - 10:30 am | Errol Friedberg (UT Southwestern)
"DNA polymerases for translesion DNA synthesis" |
10:30 am | Coffee Break |
11:00 am - 11:45 am | Robert Fuchs (Centre National de la Recherche Scientifique, Strasbourg)
"Defining the switches between replicative and bypass polymerases" |
11:45 am - 12:30 pm | Myron Goodman (University of Southern California)
"Human and bacterial hyper-mutation" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MUTATION IN HUMAN HEREDITARY AND INFECTIOUS DISEASES |
7:30 pm - 8:10 pm | Discussion Leader: Thomas Kunkel (NIEHS) "Altered mismatch repair protein functions and cancer susceptibility" |
8:10 pm - 8:50 pm | Larry Loeb (University of Washington)
"A mutator phenotype in human cancers" |
8:50 pm - 9:30 pm | Pablo Radicella (Commissariat a l'Energie Atomique)
"Role of stress and DNA repair in Helicobacter pylori genetic variability and virulence" |
WEDNESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MUTATION AVOIDANCE |
9:00 am - 9:45 am | Discussion Leader: Tomas Lindahl (Clare Hall Laboratories) "Consequences of defective uracil removal from DNA and editing in mammalian systems" |
9:45 am - 10:30 am | Barbara Sedgwick (Clare Hall Laboratories)
"Repair of alkylated bases in DNA by E. coli and human DNA dioxygenases" |
10:30 am | Coffee Break |
11:00 am - 11:45 am | Wei Yang (NIH)
"Portraits of a Y-family polymerase, mechanism for lesion-bypass and low fidelity DNA synthesis" |
11:45 am - 12:30 pm | Josef Jiricny (University of Zurich)
"The role of mismatch repair in DNA damage signalling" |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Trip to Blenheim Palace (optional)< |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MUTAGENESIS AND THE MODELING OF EVOLUTION |
7:30 pm - 8:10 pm | Discussion Leader: Lynn Caparole (Darwin in the Genome)
"Updating Darwin: mutation is modulated by natural selection" |
8:10 pm - 8:50 pm | François Taddei (Necker-Enfants Malades, Paris)
"Causes and consequences of genetic and phenotypic variability" |
8:50 pm - 9:30 pm | Allan Drummond (Caltech)
"On the conservative nature of homologous recombination" |
THURSDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MUTATION RATES IN EVOLUTION AND GENOTYPE-PHENOTYPE RELATIONSHIPS |
9:00 am - 9:45 am | Discussion Leader: Daniel Dykhuizen (SUNY, Stony Brook)
"Distribution of homoplasy in E.coli DNA sequences suggests mutational hot spots are common in nature" |
9:45 am - 10:30 am | Ivan Matic (Necker-Enfants Malades, Paris)
"Evolutionary significance of stress-induced mutagenesis in bacteria" |
10:30 am | Coffee Break |
11:00 am - 11:45 am | Suzanne Rutherford (Fred Hutchinson Cancer Research Center)
"Between genotype and phenotype: genetic buffering and the expressed mutation rate" |
11:45 am - 12:30 pm | Leah Cowen (Whitehead Institute)
"Hsp90, buffering, and the evolution of drug resistance" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 8:00 pm | Business Meeting |
8:00 pm - 9:30 pm | HUMAN MUTAGENESIS AND GENETIC DIVERSITY |
8:00 pm - 8:35 pm | Joann Sweasy (Yale University)
"Cancer-associated mutants of DNA polymerase ß induce focus formation and synthesize DNA with low fidelity" |
8:35 pm - 9:10 pm | Phillip Patten (Achaogen, Inc.)
"Directed evolution of proteins by DNA shuffling" |
9:10 pm - 9:30 pm | Discussion Leader: Miroslav Radman (Necker-Enfants Malade, Paris)
"Closing remarks - putting it all into context" |
FRIDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am | Departure |