SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE ADDRESSES |
7:30 pm - 8:15 pm | Thomas Kunkel (NIEHS)
"Using error signatures to probe the functions of yeast B family DNA polymerases" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Josef Jiricny (University of Zurich)
"Mismatch repair - batting on many wickets" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FIDELITY OF DNA SYNTHESIS |
9:00 am - 9:25 am | Session Chair: Joann Sweasy (Yale University)
"Tumor-associated mutants of DNA polymerase ß induce cellular transformation" |
9:25 am - 9:35 am | Discussion
|
9:35 am - 10:00 am | Paul Modrich (Duke University)
"Function of human MutLα in mismatch repair" |
10:00 am - 10:10 am | Discussion |
10:10 am | Group Photo / Coffee Break |
10:40 am - 11:05 am | Dorothy Erie (University of North Carolina, Chapel Hill) "AFM and single-molecule fluorescence studies of MutS-DNA interactions reveal the mechanism of mismatch recognition" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Wei Yang (NIH) "ATP and Mg2+ dependent fidelity of DNA repair and replication" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Roel Schaaper (NIEHS) "DNA replication fidelity in E. coli" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MICROBIAL MUTAGENESIS |
7:30 pm - 7:55 pm | Session Chair: Patricia Foster (Indiana University)
"Stress induced mutagenesis in bacteria" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Daniel Jarosz (MIT) "Novel regulation of alternative DNA polymerases: from substrate preference
to cell cycle control" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Miro Radman (Necker Enfants Malades, Paris) "Natural contig assembly in Deinococcus radiodurans" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Jeffrey Miller (UCLA) "Studies of mutational pathways in E. coli and B. anthracis" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BYPASS OF DNA LESIONS |
9:00 am - 9:25 am | Session Chair: Alan Lehmann (University of Sussex)
"Bypass of DNA lesions" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Robert Fuchs (Centre National de la Recherche Scientifique, Marseille) "How specialized DNA polymerases get access to the 3' end of a primer in the vicinity of a template lesion" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Zvi Livneh (Weizmann Institute of Science) "Regulation of translesion DNA synthesis by p53 and p21 keeps mutation load under control" |
10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break |
11:15 am - 11:40 am | Errol Friedberg (UT Southwestern) "TLS in higher eukaryotes" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Myron Goodman (University of Southern California) "Biochemical basis of Pol V-catalyzed RecA-mediated SOS mutagenesis" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TRANSCRIPTION AND GENETIC STABILITY |
7:30 pm - 7:55 pm | Session Chair: Ashok Bhagwat (Wayne State University)
"Transcription: opening DNA to damage" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Isao Kuraoka (National Kuyshu Cancer Center) "RNA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Paul Doetsch (Emory University) "DNA damage-induced transcriptional mutagenesis" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Mats Ljungman (University of Michigan) "The transcription stress response" |
9:25 pm - 9:30 pm | Discussion |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PROGRAMMED MUTAGENESIS |
9:00 am - 9:25 am | Session Chair: Patricia Gearhart (NIH)
"Somatic hypermutation: living with risk" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Nancy Maizels (University of Washington) "Immunoglobulin gene mutagenesis by ubiquitous factors and mechanisms" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Ursula Storb (University of Chicago) "Targeting of the cytosine deaminase AID to immunoglobulin genes" |
10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break |
11:15 am - 11:40 am | Shunichi Takeda (Kyoto University) "The role of TLS polymerases in IgV hypermutation" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Reuben Harris (University of Minnesota) "Restriction of retroelements and retroviruses by mammalian APOBEC3 proteins" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | CHROMOSOMAL MUTATIONS |
7:30 pm - 7:55 pm | Session Chair: Thomas Petes (Duke University)
"Genetic regulation of genome stability in yeast" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Kirill Lobachev (Georgia Institute of Technology) "Mechanism of chromosome breakage and rearrangements induced by unstable repeats" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Sue Wessler (University of Georgia) "Genome-wide analysis of insertions from transposable element bursts" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Christopher Pearson (The Hospital for Sick Children, University of Toronto) "Cis- and trans-factors of disease-associated trinucleotide repeat instability" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CONTROL OF MUTAGENIC PROCESSES |
9:00 am - 9:25 am | Session Chair: Stefan Jentsch (Max Planck Institute)
"Ubiquitin and SUMO as decision makers" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Hannah Klein (New York University) "Balancing homologous recombination and post-replication repair: effects of Rad51 overexpression" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Kyungjae Myung (NHGRI, NIH) "Human SHPRH (RAD5 orthologue) suppresses genomic instability through PCNA polyubiquitination" |
10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break |
11:15 am - 11:40 am | Steve Elledge (Harvard University) "Sensing and responding to DNA damage" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Tom Wilson (University of Michigan) "The influence of protein interactions and DNA joint structures on outcomes of yeast nonhomologous end joining" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MUTAGENESIS AND HUMAN DISEASE |
7:30 pm - 7:55 pm | Session Chair: Judith Campisi (Lawrence Livermore Laboratory)
"Postponing cancer and aging by RECQ helicases BLM and WRN" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Tom Prolla (University of Wisconsin) "Accelerated aging in mice carrying a mutator allele of POLG" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Alan d’Andrea (Dana-Farber Cancer Institute) "The Fanconi anemia/BRCA pathway and the DNA damage response" |
8:55 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |